Anti-Human CX3CL1/Fractalkine Reference Antibody (Quetmolimab, RUO) (HX143016)

Name: Anti-Human CX3CL1/Fractalkine Reference Antibody (Quetmolimab, RUO)
Brand: abinScience
SKU: HX143016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HX143016
Description	Research Grade Quetmolimab (HX143016) is a humanized monoclonal antibody detecting Small-inducible cytokine D1 in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG2-kappa
Expression system	Mammalian cells
Species	Human
Clonality	Monoclonal
Target	Small-inducible cytokine D1, Fractalkine, Neurotactin, C-X3-C motif chemokine 1, NTT, CX3CL1, SCYD1, FKN, CX3C membrane-anchored chemokine
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P78423
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	E-6011, 2084037-83-0
Background	Fractalkine (Small-inducible cytokine D1,Fractalkine,Neurotactin,C-X3-C motif chemokine 1,NTT,CX3CL1,SCYD1,FKN,CX3C membrane-anchored chemokine) is a ~42 kDa protein. Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. Regulates leukocyte adhesion and migration processes at the endothelium. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. 1. Nishimura, M. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 6173-80. PMID: 12055230 2. Xue, X. et al. (2011) PLoS pathogens 7, e1002162. PMID: 21829356 3. Fujita, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 5809-19. PMID: 23125415 4. Fong, AM. et al. (1998) The Journal of experimental medicine 188, 1413-9. PMID: 9782118 5. Mizoue, LS. et al. (1999) Biochemistry 38, 1402-14. PMID: 9931005 6. Bazan, JF. et al. (1997) Nature 385, 640-4. PMID: 9024663 7. Pan, Y. et al. (1997) Nature 387, 611-7. PMID: 9177350 8. Fujita, M. et al. (2014) PloS one 9, e96372. PMID: 24789099
Note	For research use only. Not suitable for clinical or therapeutic use.

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Anti-Human CX3CL1/Fractalkine Reference Antibody (Quetmolimab, RUO).pdf

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Anti-Human CX3CL1/Fractalkine Reference Antibody (Quetmolimab, RUO) (HX143016)

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