Anti-Human MAG/Siglec-4a Reference Antibody (Refanezumab, RUO) (HB948016)

Name: Anti-Human MAG/Siglec-4a Reference Antibody (Refanezumab, RUO)
Brand: abinScience
SKU: HB948016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HB948016
Description	Refanezumab (HB948016) is a research-grade recombinant antibody targeting Myelin-associated glycoprotein. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Myelin-associated glycoprotein, MAG, Siglec-4a, GMA
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P20916
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	GSK-249320, 1233953-61-1
Background	Myelin-associated glycoprotein (MAG) is a ~69 kDa protein. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane. Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides.
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

SEC-HPLC detection for Research Grade Refanezumab.
SDS-PAGE

SDS-PAGE for Research Grade Refanezumab

References

Datasheet

Anti-Human MAG/Siglec-4a Reference Antibody (Refanezumab, RUO).pdf

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Anti-Human MAG/Siglec-4a Reference Antibody (Refanezumab, RUO) (HB948016)

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