Anti-Human R-Spondin 3 Reference Antibody (Rosmantuzumab, RUO) (HV514016)

Name: Anti-Human R-Spondin 3 Reference Antibody (Rosmantuzumab, RUO)
Brand: abinScience
SKU: HV514016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HV514016
Description	Rosmantuzumab (HV514016) is a research-grade recombinant antibody targeting RSPO3. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	RSPO3, hPWTSR, hRspo3, PWTSR, R-spondin-3, Thrombospondin type-1 domain-containing protein 2, Protein with TSP type-1 repeat, Roof plate-specific spondin-3, THSD2
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9BXY4
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	OMP-131R10, 1684393-04-1
Background	R-spondin-3 (RSPO3) is a ~30 kDa protein. Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. 1. de Lau, W. et al. (2011) Nature 476, 293-7. PMID: 21727895 2. Glinka, A. et al. (2011) EMBO reports 12, 1055-61. PMID: 21909076 3. Gong, X. et al. (2012) PloS one 7, e37137. PMID: 22615920 4. Szenker-Ravi, E. et al. (2018) Nature 557, 564-569. PMID: 29769720
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

SEC-HPLC detection for Research Grade Rosmantuzumab.
SDS-PAGE

SDS-PAGE for Research Grade Rosmantuzumab.

References

Datasheet

Anti-Human R-Spondin 3 Reference Antibody (Rosmantuzumab, RUO).pdf

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Anti-Human R-Spondin 3 Reference Antibody (Rosmantuzumab, RUO) (HV514016)

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