Anti-Human CTLA-4 Reference Antibody (Sovipostobart Beta, RUO) (HB651326)

Name: Anti-Human CTLA-4 Reference Antibody (Sovipostobart Beta, RUO)
Brand: abinScience
SKU: HB651326
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HB651326
Description	sovipostobart beta (HB651326) is a research-grade recombinant antibody targeting CD152. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1, Kappa
Species	Human
Clonality	Monoclonal
Target	CD152/CTLA4
Purity	>95% as determined by SDS-PAGE.
Accession	P16410
Form	Liquid
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2649371-20-8
Background	Cytotoxic T-lymphocyte protein 4 (CD152/CTLA4) is a ~24 kDa protein. Inhibitory receptor acting as a major negative regulator of T-cell responses. Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. CD152 is the therapeutic target of ipilimumab (Yervoy). 1. Schwartz, JC. et al. (2001) Nature 410, 604-8. PMID: 11279501 2. Stamper, CC. et al. (2001) Nature 410, 608-11. PMID: 11279502 3. Teft, WA. et al. (2006) Annual review of immunology 24, 65-97. PMID: 16551244 4. Linsley, PS. et al. (1991) The Journal of experimental medicine 174, 561-9. PMID: 1714933 5. Zheng, Y. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 1683-91. PMID: 18641304 6. Ramagopal, UA. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E4223-E4232. PMID: 28484017
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade sovipostobart beta

References

Datasheet

Anti-Human CTLA-4 Reference Antibody (Sovipostobart Beta, RUO).pdf

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Anti-Human CTLA-4 Reference Antibody (Sovipostobart Beta, RUO) (HB651326)

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References

Datasheet

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