Research Grade Spesolimab (HV577016) is a humanized monoclonal antibody detecting FIL1D in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human.
Highlights
●Multi-Application — Validated across multiple applications.
Species reactivity
Human
Applications
ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Protein A/G purified from cell culture supernatant.
Accession
Q9UBH0
Form
Liquid
Storage buffer
0.01M PBS pH 7.4
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names
BI 655130, BI655130, MAB92, 2097104-58-8
Background
Interleukin-36 receptor antagonist protein (FIL1D,Interleukin-1 family member 5,IL-36Ra,IL1HY1,Interleukin-36 receptor antagonist protein,IL1RP3,IL-1RP3,IL-1ra homolog 1,Interleukin-1-like protein 1,IL-1-related protein 3,IL1L1,Interleukin-1 HY1,IL-1HY1,Interleukin-1 delta,FIL1 delta,IL-1 delta,IL-1L1,Interleukin-1 receptor antagonist homolog 1,IL36RN,IL1F5,IL-1F5) is a ~16 kDa protein. Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
Note
For research use only. Not suitable for clinical or therapeutic use.
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