Anti-Human Complement Component C1q Reference Antibody (Tanruprubart, RUO) (HY334026)

Name: Anti-Human Complement Component C1q Reference Antibody (Tanruprubart, RUO)
Brand: abinScience
SKU: HY334026
Price: 176 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.	HY334026
Description	tanruprubart (HY334026) is a research-grade recombinant antibody targeting C1q. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG4, Kappa
Species	Human
Clonality	Monoclonal
Target	C1q
Purity	>95% as determined by SDS-PAGE.
Accession	P02745
Form	Liquid
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2065212-40-8
Background	Complement C1q subcomponent subunit A is a ~26 kDa protein. Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens: C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain. Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system. The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM. The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system. 1. Kishore, U. et al. (2003) Journal of immunology (Baltimore, Md. : 1950) 171, 812-20. PMID: 12847249 2. Gadjeva, MG. et al. (2008) Biochemistry 47, 13093-102. PMID: 19006321 3. Diebolder, CA. et al. (2014) Science (New York, N.Y.) 343, 1260-3. PMID: 24626930 4. Ugurlar, D. et al. (2018) Science (New York, N.Y.) 359, 794-797. PMID: 29449492 5. Duncan, AR. et al. (1988) Nature 332, 738-40. PMID: 3258649 6. Zwarthoff, SA. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34155115 7. Lin, TY. et al. (1980) The Journal of biological chemistry 255, 7756-62. PMID: 6249812 8. Burton, DR. et al. (1980) Nature 288, 338-44. PMID: 6776418
Note	For research use only. Not suitable for clinical or therapeutic use.