

| Catalog No. | JN060036 | ||||
|---|---|---|---|---|---|
| Description |
Research Grade tepsababart (JN060036) is a human monoclonal antibody. Suitable for Staphylococcus aureus.
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| Species reactivity | Staphylococcus aureus | ||||
| Applications | ELISA, Bioactivity: FCM, Functional assay, Research in vivo | ||||
| Host species | Human | ||||
| Clonality | Monoclonal | ||||
| Isotype | IgG1, kappa | ||||
| Expression system | Mammalian cells | ||||
| Nature | Recombinant | ||||
| Target | Clumping factor A, Fibrinogen receptor A, Fibrinogen-binding protein A, clfA | ||||
| Endotoxin level | < 10 EU/mg as determined by LAL method. | ||||
| Purity | >95% as determined by SDS-PAGE. | ||||
| Purification | Protein A/G purified from cell culture supernatant. | ||||
| Accession | Q53653 | ||||
| Form | Liquid | ||||
| Storage buffer | 0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| Background | Clumping factor A (clfA) is a ~97 kDa protein. Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps, which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing. Significantly decreases macrophage phagocytosis possibly thanks to the clumps, clumped bacteria being too large to be phagocytosed. Dominant factor responsible for human platelet aggregation, which may be an important mechanism for initiating infective endocarditis. | ||||
| Note | For research use only. Not suitable for clinical or therapeutic use. |
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