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Anti-Human CD282/TLR2 Reference Antibody (Tomaralimab, RUO) (HT188016)

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Anti-Human CD282/TLR2 Reference Antibody (Tomaralimab, RUO)

Anti-Human CD282/TLR2 Reference Antibody (Tomaralimab, RUO)

Anti-Human CD282/TLR2 Reference Antibody (Tomaralimab, RUO)

Anti-Human CD282/TLR2 Reference Antibody (Tomaralimab, RUO)

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100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.	HT188016
Description	Research Grade Tomaralimab (HT188016) is a monoclonal antibody.
Applications	ELISA, FACS, Functional assay, antagonist
Clonality	Monoclonal
Target	CD282, TIL4, TLR2, Toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O60603
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Toll-like receptor 2 is a ~89 kDa protein. Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. 1. Jin, MS. et al. (2007) Cell 130, 1071-82. PMID: 17889651 2. Lancioni, CL. et al. (2011) Infection and immunity 79, 663-73. PMID: 21078852 3. Brightbill, HD. et al. (1999) Science (New York, N.Y.) 285, 732-6. PMID: 10426995 4. Aliprantis, AO. et al. (1999) Science (New York, N.Y.) 285, 736-9. PMID: 10426996 5. Bulut, Y. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 987-94. PMID: 11441107 6. Jung, SB. et al. (2006) Infection and immunity 74, 2686-96. PMID: 16622205 7. Drage, MG. et al. (2009) Cellular immunology 258, 29-37. PMID: 19362712 8. Bulut, Y. et al. (2005) The Journal of biological chemistry 280, 20961-7. PMID: 15809303 9. Triantafilou, M. et al. (2006) The Journal of biological chemistry 281, 31002-11. PMID: 16880211
Note	For research use only.

Images

Bioactivity

SEC-HPLC detection for Research Grade Tomaralimab.
SDS-PAGE

SDS-PAGE for Research Grade Tomaralimab

References

Datasheet

Anti-Human CD282/TLR2 Reference Antibody (Tomaralimab, RUO).pdf

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Formula

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Anti-Human CD282/TLR2 Reference Antibody (Tomaralimab, RUO)