Anti-Human VAP-1/AOC3 Reference Antibody (Vapaliximab, RUO) (HS721026)

Name: Anti-Human VAP-1/AOC3 Reference Antibody (Vapaliximab, RUO)
Brand: abinScience
SKU: HS721026
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HS721026
Description	Vapaliximab (HS721026) is a research-grade recombinant antibody targeting Membrane primary amine oxidase. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Chimeric
Isotype	IgG2-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Membrane primary amine oxidase, AOC3, SSAO, Semicarbazide-sensitive amine oxidase, Vascular adhesion protein 1, VAP-1, HPAO, Copper amine oxidase, VAP1
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q16853
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2D10, 336801-86-6
Background	Amine oxidase [copper-containing] 3 (AOC3/VAP-1) is a ~84 kDa protein. Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Has a preference for the primary monoamines methylamine and benzylamine. Could also act on 2-phenylethylamine but much less efficiently. At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. 1. Kaitaniemi, S. et al. (2009) Cellular and molecular life sciences : CMLS 66, 2743-57. PMID: 19588076 2. Bligt-Lindén, E. et al. (2013) Journal of medicinal chemistry 56, 9837-48. PMID: 24304424 3. Smith, DJ. et al. (1998) The Journal of experimental medicine 188, 17-27. PMID: 9653080 4. Salmi, M. et al. (1997) The Journal of experimental medicine 186, 589-600. PMID: 9254657
Note	For research use only. Not suitable for clinical or therapeutic use.