Satralizumab ELISA Kit (DY583028)

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Overview

Catalog No.	DY583028
Description	Satralizumab ELISA Kit (DY583028) — Quantitative sandwich ELISA for Satralizumab. Sample: Plasma, Serum. Range: 78.125 - 5, 000 ng/mL. Sensitivity: 33.12 ng/mL. Highlights ●Sandwich Format — High specificity, reliable quantification. ●High Sensitivity — Optimized for low-abundance target detection. ●Ready-to-Use — Complete kit with pre-coated plates included.
Sample type	Plasma, Serum
Sensitivity	33.12 ng/mL
Range	78.125 - 5, 000 ng/mL
Accession	P08887
Applications	ELISA
Detection method	Colorimetric
Assay type	Quantitative
Recovery	80-120%
Shipping	2-8 ℃
Stability and Storage	The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.
Specifications	Satralizumab
Alternate Names	Sapelizumab, SA-237, SA237, satralizumab-mwg, 1535963-91-7
Background	Interleukin-6 receptor subunit alpha is a ~51 kDa protein. Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. 1. Larsen, JV. et al. (2017) Molecular and cellular biology 37. PMID: 28265003 2. Kang, S. et al. (2019) Immunity 50, 1007-1023. PMID: 30995492 3. Spencer, S. et al. (2019) The Journal of experimental medicine 216, 1986-1998. PMID: 31235509
Note	For Research Use Only.