Bone Morphogenetic Protein 2 (BMP-2) is a member of the TGF-β superfamily that plays a central role in osteogenesis, chondrogenesis, and embryonic development. BMP-2 signals through BMPR-IA/BMPR-IB and BMPR-II to activate the SMAD1/5/8 pathway, driving mesenchymal stem cell differentiation toward the osteoblast lineage. Recombinant BMP-2 is FDA-approved for clinical use in spinal fusion and fracture healing, making it one of the most translationally relevant growth factors in orthopedic research.
abinScience provides a comprehensive BMP-2 reagent panel — recombinant antibodies with flow cytometry conjugates, a polyclonal antibody, an InVivoMAb-grade neutralizing antibody for in vivo studies, and recombinant BMP-2 proteins from human and rat.
Why abinScience?
✓ InVivoMAb grade — Endotoxin-tested, azide-free, in vivo-ready anti-BMP-2 for animal studies
✓ Flow cytometry panel — Clone SAA0423 in FITC, PE, APC, PerCP conjugates
✓ Multi-species proteins — Human and rat recombinant BMP-2 in His-tag and Fc-tag formats
✓ Polyclonal option — Rabbit polyclonal anti-BMP2 with human, mouse, and rat reactivity
Available Products
Anti-BMP2 Antibodies
Recombinant, polyclonal, and InVivoMAb-grade anti-BMP-2 antibodies.
BMP-2 Recombinant Proteins
Purified recombinant BMP-2 proteins for osteogenic differentiation assays, receptor binding studies, and functional experiments.
About the Target
Gene: BMP2 (also: BMP-2, BMP2A)
UniProt: P12643 (Human)
Molecular weight: ~44 kDa (precursor); ~13 kDa per monomer (mature, active homodimer ~26 kDa)
Signaling: BMP-2 → BMPR-I/II → SMAD1/5/8 → RUNX2 → osteoblast gene transcription
BMP-2 is secreted as a disulfide-bonded homodimer. After proteolytic cleavage of the prodomain, mature BMP-2 binds to BMPR-IA (ALK3) or BMPR-IB (ALK6) and recruits BMPR-II, activating the canonical SMAD pathway. BMP-2 is indispensable for skeletal development — Bmp2 knockout in mice is embryonic lethal — and recombinant BMP-2 (Infuse Bone Graft / InductOs) is one of very few growth factors approved for clinical orthopedic use.
Frequently Asked Questions
What is BMP-2 used for in research?
BMP-2 is primarily used to study osteogenic differentiation of mesenchymal stem cells, bone healing and regeneration, skeletal development, and TGF-β/SMAD signaling. It is also studied in cancer contexts, where BMP-2 can have both tumor-suppressive and tumor-promoting roles depending on the cancer type.
What is the InVivoMAb anti-BMP-2 antibody?
The InVivoMAb formulation (Iv0058) is specifically prepared for in vivo administration in animal studies. It features low endotoxin levels, no preservatives (azide-free), and high purity suitable for systemic injection. It can be used to neutralize BMP-2 in vivo to study loss-of-function phenotypes in bone biology models.
Which BMP-2 protein format should I use for osteogenic differentiation?
For cell culture differentiation assays, use the His-tagged BMP-2 protein. The Fc-tagged version creates a bivalent format with extended half-life that may be more suitable for sustained-release scaffold loading or receptor binding kinetics studies (SPR/BLI).
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