Getah Virus (GETV) Research Reagents — Antibodies & Recombinant Proteins

Spike Glycoprotein E2 — Receptor Binding & Neutralization Target
E2 is the major surface glycoprotein that mediates receptor attachment and is the primary target for virus-neutralizing antibodies. E2 forms a heterodimer with E1 and assembles into trimeric spikes on the virion surface. Anti-E2 antibodies block initial receptor binding and are the most potent neutralizers. E2 is also the key antigen for serological surveillance ELISA development — critical for GETV outbreak monitoring in equine and swine populations. Available: recombinant E2 protein N-His (VK157022) and anti-E2 polyclonal antibody (VK157024).

Spike Glycoprotein E1 — Class II Fusion Protein
E1 is the class II fusion glycoprotein that mediates low-pH-triggered membrane fusion in endosomes. E1 is shielded by E2 in the prefusion state and is more conserved across alphavirus species than E2, making anti-E1 reagents useful for cross-alphavirus comparative studies. Available: recombinant E1 protein N-His (VK157012) and anti-E1 polyclonal antibody (VK157014).

Which protein is better for GETV serosurvey ELISA — E1 or E2?
E2 (VK157022) is recommended for species-specific GETV serology — E2 contains the hypervariable neutralizing epitopes that distinguish GETV from related alphaviruses. E1 is more conserved and may cross-react with SINV, CHIKV, and RRV sera. Use E2 for GETV-specific detection and E1 for pan-alphavirus screening.

Do GETV reagents cross-react with CHIKV or SINV?
E2 shares limited amino acid identity with CHIKV E2 (~55%) and SINV E2 (~60%), so E2-based reagents are relatively GETV-specific. E1 is more conserved (~70–75% identity with SINV E1), and our anti-E1 pAb may show partial cross-reactivity with related Old World alphaviruses. For confirmed SINV-specific and CHIKV-specific reagents, see our dedicated pages.

Why is GETV getting more research attention?
GETV has been expanding geographically and into new host species. Large outbreaks in Chinese pig farms (2017–present) and Japanese racehorses, combined with serological evidence of human exposure, have raised concern about GETV as an emerging zoonotic threat. There are currently no approved GETV vaccines for any species, and diagnostic tools remain limited — our E1/E2 proteins and antibodies fill a critical reagent gap.

Explore reagents for related alphaviruses:

GETV ✓ CHIKV SINV Dengue (DENV) West Nile (WNV) YFV