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Research Grade Nesvacumab (HT073036)

데이터시트 제품 공유 정보 복사

Research Grade Nesvacumab

Research Grade Nesvacumab

Research Grade Nesvacumab

Research Grade Nesvacumab

Research Grade Nesvacumab

Research Grade Nesvacumab

Research Grade Nesvacumab

Research Grade Nesvacumab

가격(USD): $

사양:

100ug
1mg

수량:

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개요
이미지
참고 문헌
데이터시트

개요

카탈로그 번호	HT073036
설명	Nesvacumab (HT073036) is a research-grade recombinant antibody targeting ANG-2. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
이소타입	IgG1-nd
발현 시스템	Mammalian Cells
클론성	Monoclonal
타겟	ANG-2, ANGPT2, Angiopoietin-2
내독소 수준	Please contact the lab for this information.
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	O15123
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
대체 이름	REGN-910, 1296818-77-3
배경	Angiopoietin-2 (ANGPT2/ANG-2) is a ~56 kDa protein. Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis. 1. Lee, HJ. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 1200-8. PMID: 15284220 2. Yacyshyn, OK. et al. (2009) Angiogenesis 12, 25-33. PMID: 19116766 3. Yuan, HT. et al. (2009) Molecular and cellular biology 29, 2011-22. PMID: 19223473 4. Maisonpierre, PC. et al. (1997) Science (New York, N.Y.) 277, 55-60. PMID: 9204896 5. Leppänen, VM. et al. (2020) Science translational medicine 12. PMID: 32908006
참고사항	For research use only. Not suitable for clinical or therapeutic use.

이미지

SEC-HPLC

SEC-HPLC detection for Research Grade Nesvacumab.
Bioactivity

Detects Human ANGPT2 in indirect ELISAs.
Bioactivity

Detects Human ANGPT2 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Nesvacumab

참고 문헌

Angiopoietin-2 binds to FGFR2, inhibits FGF-FGFR2 signaling, and delays cutaneous wound healing by inhibiting wound angiogenesis

데이터시트

Research Grade Nesvacumab.pdf

Formula

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Working Solution

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Research Grade Nesvacumab