InVivoMAb Anti-Human CXCL12/SDF-1 Antibody (Iv0090) (HW376010)

Name: InVivoMAb Anti-Human CXCL12/SDF-1 Antibody (Iv0090)
Brand: abinScience
SKU: HW376010
Price: 370 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

100ug
1mg

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.	HW376010
Description	InVivoMAb Anti-Human CXCL12/SDF-1 (Iv0090) [Iv0090] (HW376010) is a human monoclonal antibody detecting Intercrine reduced in hepatomas in ELISA, Neutralization. Suitable for Human.
Species reactivity	Human
Applications	ELISA, Neutralization
Host species	Human
Clonality	Monoclonal
Isotype	IgG1, kappa
Clone ID	Iv0090
Target	Intercrine reduced in hepatomas, hSDF-1, Stromal cell-derived factor 1, SDF-1, Pre-B cell growth-stimulating factor, SDF1, SDF1A, C-X-C motif chemokine 12, SDF1B, CXCL12, IRH, PBSF, hIRH
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Associated products	pH 7.4 Dilution Buffer
Purification	Protein A/G purified from cell culture supernatant.
Accession	P48061
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Stromal cell-derived factor 1 (CXCL12/SDF-1) is a ~10 kDa protein. Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for CXCL12/SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. 1. Malik, M. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 4632-7. PMID: 18802065 2. Liu, Y. et al. (2024) Cell reports 43, 114578. PMID: 39093700 3. Oberlin, E. et al. (1996) Nature 382, 833-5. PMID: 8752281 4. Balabanian, K. et al. (2005) The Journal of biological chemistry 280, 35760-6. PMID: 16107333 5. Kalatskaya, I. et al. (2009) Molecular pharmacology 75, 1240-7. PMID: 19255243 6. Fujita, M. et al. (2018) The Biochemical journal 475, 723-732. PMID: 29301984
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)