All antibodies are for Research Use Only (RUO) and not for diagnostic or therapeutic use.

Neutralizing Antibodies | Virus Blockade mAbs

Q: Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show functional activity (PRNT/pseudovirus), whereas binding antibodies may not block infection.

Q: PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT uses infectious virus (gold standard); pseudovirus enables BSL-2 functional readouts; sVNT screens receptor blocking on plates for fast throughput.

Q: How do I interpret IC50/ID50 values?

Lower IC50/ID50 denotes stronger neutralization under matched conditions; compare across the same assay setup only.

abinScience neutralizing antibodies (NAbs) block viral entry or fusion and are validated by PRNT, pseudovirus, or surrogate receptor–ligand blocking (sVNT), with IC50/ID50 titers reported where applicable. Panels span coronaviruses (e.g., RBD/ACE2 blockers), influenza (HA), RSV (F), and arboviruses (DENV/ZIKV/CHIKV). Products provide epitope/mechanism notes, variant/strain coverage, isotype and Fc options (native/engineered), and lot-specific CoAs. RUO

Why Researchers Choose abinScience

Functional Validation PRNT, pseudovirus, sVNT with IC50/ID50

Mechanism Annotated Receptor/fusion/capsid blocking

Variant Coverage Documented on datasheets

Isotype & Fc Options IgG/IgA, effector-on/off

Lot-Specific QC CoA, storage, handling guidance

Shop by Pathogen

Shop by Mechanism

Selection Guide

Assay Readout & Potency: PRNT/pseudovirus for functional titers (IC50/ID50); sVNT for rapid screening. Compare IC50 across matched assay conditions.
Epitope & Mechanism: Choose receptor-blocking (e.g., RBD–ACE2) vs. fusion blockers (e.g., RSV F); confirm neutralization across relevant variants/strains.
Isotype & Fc: IgG for general use; IgA for mucosal models; select native vs. engineered Fc (effector-on/off) to match your MoA study.
Matrix & Format: Prefer unconjugated for neutralization assays; use labeled versions for ELISA/flow tracking.
Controls: Include binding-only mAbs, isotypes, and positive NAb controls to benchmark assay performance.

Applications

Neutralization potency ranking and MoA studies

Vaccine/convalescent serum research and escape-variant assessment

Assay development: PRNT, pseudovirus, sVNT and competitive ELISAs

Documents & QC

Datasheet with assay type (PRNT/pseudovirus/sVNT), IC50 and acceptance criteria

Variant/strain coverage, epitope notes and cross-reactivity

Lot-specific CoA; storage, stability and reconstitution

FAQs

Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show activity in PRNT/pseudovirus assays, while binding antibodies recognize the antigen without necessarily blocking infection.

PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT is the classical infectious-virus gold standard; pseudovirus offers BSL-2 functional readouts; sVNT screens receptor blocking on plates. Choose per biosafety, throughput and MoA.

How do I interpret IC50/ID50 values?

Lower IC50/ID50 indicates stronger neutralization under stated conditions; compare only across matched cell lines, MOI, and incubation protocols.

RUO disclaimer

All antibodies are for Research Use Only and not for diagnostic or therapeutic use.

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Antibodies (727)
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ROR1/NTRKR1 (1)

Intermediate capsid protein VP6 (1)

RBD (S6P trimer) (3)

CCL14/NCC-2 (1)

G/Major surface glycoprotein G (2)

LRRC15/LIB (1)

aPC/Activated protein C (3)

LGR5/GPR49 (1)

p67 (1)

CD21/CR2 (1)

AFP/Alpha-fetoprotein (1)

CD37/TSPAN26 (2)

Procapsid [(VP0/1/3) 5] 12 (2)

CD222/IGF2R (1)

gH/gL Complexes (2)

STEAP1 (1)

p21/Mature core protein (1)

ACVRL1/ALK-1 (1)

Pre-F/Fusion glycoprotein F0 (2)

SplB (1)

CD96 (2)

CXCL1/NAP-3/GRO-alpha (1)

PTP4A1/PRL1 (1)

Glycoprotein G (17)

CD226/DNAM-1 (1)

IL31RA (1)

Tityustoxin VII/Toxin VII/Ts7 (1)

TNFSF9/4-1BBL (2)

CD268/TNFRSF13C (2)

GP/Envelopment polyprotein (1)

L1/Major capsid protein L1 (2)

IGF2 (1)

APP/Amyloid beta (1)

Capsid protein VP25 (2)

Capsid protein VP2 (2)

Virionprotein 1/VP1 (1)

IL12B/IL-12 p40 (1)

Galectin-3/Gal-3 (1)

Capsid protein VP 1/2/3 (2)

GPRC5D (1)

CD52 (1)

E1 & E2 (gp35 & gp70) (3)

CD295/LEPR (1)

A29L (2)

CCL1/I-309 (1)

Capsid protein VP3 (1)

THPO/Thrombopoietin (1)

D8L (2)

Envelopeglycoprotein E2/gp55 (2)

CXCL9/MIG (1)

CD337/NCR3/NKp30 (1)

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fimH (1)

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DT/Diphtheria toxin (3)

long-chain α-neurotoxins (1)

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Fusion Protein (1)

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CD152/CTLA4 (4)

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gB (2)

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gB/Envelope glycoprotein B (7)

Spike (5)

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IL10 (1)

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APOE (1)

L2/Minor capsid protein L2 (2)

EGFL7 (1)

PTP4A3/PRL3 (1)

MERS-CoV RBD (1)

Alpha-cobratoxin (1)

TSLP (1)

LRP6 (1)

RBP2b (1)

Rabbit hemorrhagic disease virus (RHDV) Capsid protein (1)

Hepacivirin/NS3P/Viroporin p70 (3)

NGF/Beta-NGF (2)

Major surface glycoprotein G (3)

CNR1/CB1 (3)

SFRP1 (1)

gp120/Glycoprotein 120 (1)

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long-chain neurotoxin (1)

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BMP10 (1)

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ANGPTL4 (5)

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F/Fusion glycoprotein F0 (16)

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E8L (2)

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Capsid (1)

HA/Hemagglutinin (2)

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L1R/Protein L1 (4)

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Major capsid protein L1 (11)

iga/IgA1 protease (1)

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IFNB1/IFN-beta (1)

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VWF (1)

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E7/Protein E7 (4)

RHDV VP60 (1)

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ADAMTS4 (4)

PSCA (1)

CCL17/TARC (1)

EDB & CD3E (1)

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ProteinUL128 & UL131A (1)

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H3L (2)

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Capsid protein (13)

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VEGFA (1)

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Envelope protein E (13)

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ERVW-1/HERV-W-Env (1)

RBD (23)

SSTR2/SRIF-1 (1)

Outer capsid protein VP4 (1)

GDF15/MIC1 (1)

IL22 (1)

A27L (5)

Mature virion in Complex [(VP0/1/3)5]12 (2)

CXCL10/IP-10 (1)

protruding (P) domain (1)

IL38/IL1F10 (2)

ROBO2 (1)

gp32/gp35/Envelope glycoprotein E1 (1)

CXCL12/SDF-1 (1)

CD228/MELTF (1)

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Gn (9)

RSPO3 (1)

CDH1/CDH11 (1)

IL2 (1)

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STAT3 (1)

Neuropeptide Y/NPY (1)

gH/Envelope glycoprotein H (1)

CDH11 (1)

Ly6g/Ly-6G.1 (2)

G9&A16 complex (2)

short-chain neurotoxin (1)

EGFRvIII-specific/EGFR variant III (2)

Protein prM/prM (3)

LTA/TNF-beta (1)

PTHrP/PTHLH(1-34) (1)

GPC (18)

A35R (5)

Outer capsid glycoprotein VP7 (1)

ADAMTS5 (2)

VLP (1)

IL6 (1)

Genome polyprotein (5)

ACE2 (3)

CD132/IL2RG (1)

SLC39A6/LIV-1 (1)

BDNF (1)

S/Spike glycoprotein (2)

Beta-toxin Cl13/Cb3 (3)

CD279/PD-1 (9)

VTCN1/B7-H4 (1)

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env/Envelope protein (1)

gp125 (1)

shiga toxin type 2/stx2B (1)

Capsid protein VP1 (2)

IL1A/IL1F1 (1)

TSG101 (2)

Fusion glycoprotein F0 (5)

DPEP3 (1)

IL23A (1)

CD100/SEMA4D (3)

CXCL11/I-TAC (1)

NS1/gp68/gp70 (40)

OSM/Oncostatin-M (1)

IL21 (1)

CSF1/M-CSF (1)

RAGE/AGER (1)

S2 Protein (3)

Hemagglutinin/HA (1)

Hemagglutinin (1)

IFNG/IFN-gamma (2)

CXCL4/PF4 (1)

gp120 (2)

gE/Envelope glycoprotein E (1)

ARC (3)

GPA33 (1)

CCL11/Eotaxin (1)

CD137/4-1BB (2)

IFNA1/Interferon alpha-D (1)

S1 N-terminal domain/S1-NTD (3)

gH/BXLF2 (2)

F12/Coagulationfactor XII (1)

Spike glycoprotein 2 (5)

HSV- gB (1)

shiga toxin type 2A/stx2A (1)

IL1B/IL1F2 (1)

env/Env polyprotein (4)

DKK1 (2)

BMP4 (1)

M1R (4)

FOLH1/PSMA (1)

P domain (4)

IFN α2/IFNA2 (1)

ATTR/Transthyretin amyloidosis (5)

TNFa/TNF-alpha (1)

LAMP5 (2)

CTGF/CCN2 (1)

stxB/SLT-1b/VT1 (2)

RBD (Omicron/JN.1) (2)

mature virion in complex (5)

CD198/CCR8 (4)

Spike glycoprotein E1 (2)

CCL2/MCP-1 (1)

SAA (1)

Fusion glycoprotein (3)

PA/pagA/PA-83 (2)

CD48 (1)

CD73/NT5E (2)

Dupilumab (2)

GP1 (2)

CD84 (1)

ENT2/SLC29A2 (1)

gB/UL27 (1)

ANGPTL3 (1)

Structural polyprotein (1)

CD62L/SELL (1)

Neuraminidase/NA (4)

lukF (1)

CLDN3/Claudin-3 (1)

gp46 (2)

CD227/MUC1 (1)

InlB/Internalin B (1)

IL36RN/IL-1F5/IL-36Ra (1)

env/Envpolyprotein (1)

CD124/IL4RA (1)

IL31 (4)

Envelope glycoprotein GP350 (1)

EDE1 (1)

APCS/PTX2 (1)

IL17C (1)

CD8a/Lyt2 (3)

E2s (2)

E6/Protein E6 (1)

IFNAR1 (1)

ADM/Adrenomedullin (1)

CD274/PD-L1 (2)

GP/Glycoprotein (5)

IL20 (1)

CA9 (1)

sLea/CA19-9 (1)

shiga toxin type 1B/stx1B (2)

botA/BOTOX (1)

GDF11/BMP11 (1)

ALPP/PLAP (1)

PDGFC (1)

Virionprotein 1/2/3 (1)

H3L/Ag35 (2)

HGF (1)

CD40/TNFRSF5 (1)

CSF2/GM-CSF (1)

Alpha-toxin/hly (3)

CD205/LY75/DEC-205 (1)

IGF1 (1)

wlaB/pglK (1)

MUC5AC (1)

ROBO4 (1)

pro-MSTN/GDF8 (1)

pfo/Perfringolysin O/Theta-toxin (3)

CDH17/Cadherin-17 (1)

RBD (Omicron/KP.2) (2)

NS1/Non-structural protein 1 (1)

FGF21 (1)
Species

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Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)

Reston ebolavirus (REBOV) (1)

Human adenovirus 3 (HAdV-3) (1)

Dobrava-Belgrade virus (DOBV) (2)

Human papillomavirus 16 (HPV16) (2)

Human respiratory syncytial virus (HRSV) (12)

Bundibugyo ebolavirus (BDBV) (1)

Human immunodeficiency virus 1 (HIV-1) (9)

Plasmodium vivax (2)

Seoul virus (SEOV) (2)

Human cytomegalovirus (HCMV/HHV-5) (7)

Human papillomavirus 58 (HPV58) (3)

Streptococcus pneumoniae (1)

Coxsackievirus B1 (CBV1) (3)

Rat (1)

Ebola virus (EBOV) (1)

Machupo virus (MACV) (1)

Tai Forest ebolavirus (TAFV) (1)

Clostridium botulinum (2)

Human papillomavirus 59 (HPV59) (1)

Porcine circovirus 2 (PCV2) (2)

Dengue virus type 2 (DENV-2) (8)

E. coli (4)

Japanese encephalitis virus (JEV) (1)

Andes virus (ANDV) (2)

Epstein-Barr virus (EBV/HHV-4) (2)

Human endogenous retroviruses W (HERV-W) (1)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)

Rotavirus (RV) (1)

Sudan ebolavirus (SEBOV) (1)

Monkey (1)

Clostridioides difficile (2)

Sin Nombre virus (SNV) (2)

Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)

Cat (1)

Zika virus (ZIKV) (4)

Lassa virus (LASV) (1)

Rotavirus A (RV-A) (3)

Dengue virus type 1 (DENV-1) (1)

Chikungunya virus (CHIKV) (1)

Mouse (33)

Human (177)

Poliovirus type 1 (PV1) (2)

Nipah virus (NiV) (13)

Hepatitis C Virus (HCV) (9)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (22)

Dengue virus type 3 (DENV-3) (1)

Hepatitis E virus/HEV (1)

Coxsackievirus A16 (CVA16) (2)

Human metapneumovirus (HMPV) (4)

Dengue virus type 4 (DENV-4) (1)

Suid alphaherpesvirus 1 (SuHV-1/PRV) (2)

Human herpesvirus 1 (HSV-1/HHV-1) (3)

Influenza A virus (Flu A) (5)

Staphylococcus aureus (3)

Zaire ebolavirus (ZEBOV) (6)

Hantaan virus (HTNV) (2)

Campylobacter jejuni subsp. (1)

Human parvovirus B19 (HPV B19) (3)

Bovine respiratory syncytial virus (BRSV) (2)

Rabbit (2)

Enterovirus 71 (EV71) (4)

Varicella-zoster virus (VZV/HHV-3) (4)

Hendra virus (HeV) (2)

Junin mammarenavirus (JUNV) (1)

Human metapneumovirus (2)

Orthohantavirus puumalaense (PUUV) (1)

Human papillomavirus 6 (HPV6) (1)

Human astrovirus-8 (HAtVs) (1)

Human hepatitis A virus (HHAV) (1)

Puumala virus (PUUV) (2)

Dog (10)

Brazilian scorpion (1)
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WB (59)

neutralizing (1)

Cell Depletion (1)

Western blot (1)

SPR (46)

FuncS (4)

Antagonist (1)

in vivo research (1)

ICC (3)

in vivo protection (1)

Nneutralization (1)

in vivo neutrophil depletion (2)

in vitro neutralization (1)

in vivo study (1)

FCM (120)

in vivo MDSC depletion (2)

in vivo CTLA-4 neutralization (2)

NK cell activation (1)

BLI (4)

in vivo intra-tumoral regulatory T cell depletion (2)

Neutralizatio (1)

DB (3)

IF (22)

IHC (18)

Blocking (2)

IP (9)

in vivo neutralization (5)

in vivo (2)

Neutralization (706)

Cell Isolation (1)

RIA (1)

in vivo CD8+ T cell depletion (1)

ELISA (621)

IB (1)
Reactivity

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Bovine viral diarrhea virus (BVDV) (2)

Hepatitis E virus/HEV (3)

Klebsiella pneumoniae (1)

E. coli (1)

Corynephage omega (3)

Ophiophagus hannah (1)

Nipah virus (1)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (1)

HSV-2 (3)

HCoV-229E (2)

Semliki Forest virus (SFV) (1)

HAstV-1 (2)

Influenza A virus (H7N3) (2)

Measles virus (MeV) (2)

Yellow Fever Virus (YFV) (1)

Clostridium tetani (1)

Heartland Virus (HRTV) (1)

Coxsackievirus B1 (CVB1) (3)

Crimean-Congo hemorrhagic fever virus (2)

Rabies virus (RABV) (6)

Influenza A virus (H7N9) (1)

Naja kaouthia (1)

Human papillomavirus 16 (HPV16) (13)

Rabbit hemorrhagic disease virus (RHDV) GI.2 (1)

Rat (5)

Zika virus (ZIKV) (1)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (8)

Human respiratory syncytial virus (HRSV) (5)

Streptococcus equisimilis (1)

Canine parvovirus (1)

Human astrovirus-8 (HAtVs) (1)

Norwalk virus (3)

SARS-CoV (1)

Parainfluenza virus 5 (PIV5) (1)

Pig (1)

Venezuelan equine encephalitis virus (VEEV) (1)

Monkeypox virus (MPXV) (12)

West Nile virus (WNV) (1)

Human (57)

Nipah virus (NiV) (13)

Scorpion (2)

Western equine encephalitis virus (WEEV) (1)

Vesicular stomatitis Indiana virus (VSIV) (2)

Lassa virus (LASV) (16)

HIV-1 (1)

SARS-CoV-2 (1)

severe fever with thrombocytopenia syndrome virus (SFTSV) (8)

Influenza B virus (2)

Human cytomegalovirus (HCMV/HHV-5) (1)

Monkey (1)

Clostridioides difficile (2)

Chikungunya virus (1)

Influenza A virus (H7N1) (1)

Vaccinia virus (VACV) (20)

Eastern equine encephalitis virus (EEEV) (1)

Hendra virus (HeV) (12)

MERS-CoV (2)

Monkeypox virus (5)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (5)

Foot-and-mouth disease virus (FMDV) (2)

Mexican scorpion (3)

RD114 retrovirus (1)

Dengue Virus type 1 (DENV-1) (1)

Ross River virus (RRV) (2)

Influenza A virus (1)

Porcine circovirus 2 (PCV2) (1)

IgG1b12 (1)

Dengue virus (1)

Human coronavirus HKU1 (HCoV-HKU1) (1)

Epstein-Barr virus (EBV/HHV-4) (3)

HCoV-OC43 (1)

Sin Nombre Virus (1)

Tick-borne encephalitis virus (1)

Junin mammarenavirus (JUNV) (3)

Homo sapiens (Human) (1)

Bacteriophage H19B (2)

Mouse (25)

Chikungunya virus (CHIKV) (4)

Bacillus anthracis (2)

Dengue Virus type 2 (DENV-2) (1)

Machupo virus (MACV) (1)

Norwalk virus (NV) (5)

O’nyong’nyong virus (ONNV) (1)

Human T-cell leukemia virus 1 (HTLV-1) (2)

Listeria monocytogenes (1)

Epstein-Barr virus (HHV-4) (Human herpesvirus 4) (1)

Zika virus (1)

Hepatitis E virus (2)

Mayaro virus(MAYV) (1)

HCoV-NL63 (1)

Dengue Virus type 3 (DENV-3) (1)

Puumala virus (1)

Hepatitis C Virus (HCV) (43)

Clostridium botulinum (1)

Human metapneumovirus (HMPV) (1)

Coxsackievirus A16 (CVA16) (3)

Japanese encephalitis virus (JEV) (2)

Clostridium perfringens (3)

Escherichia coli (1)

Theileria parva (1)

Human astrovirus-2 (1)

Hendra virus (1)

Staphylococcus aureus (3)

Influenza A virus H7 subtype (2)

HSV-1 (3)

O'nyong'nyong virus (ONNV) (1)

Dengue Virus type 4 (DENV-4) (1)

Guertu Virus (GTV) (3)

Human enterovirus 71 (EV71) (3)

Murine norovirus 1 (MNV) (1)

Poliovirus type 1 (PV1) (1)
Host species

0 selected

Cat (1)

Human (463)

Mouse (215)

Alpaca (23)

Rat (10)

Rabbit (2)

Dog (8)
Clonality

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Monoclonal (727)
Conjugate

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Unconjugated (727)