All antibodies are for Research Use Only (RUO) and not for diagnostic or therapeutic use.

Neutralizing Antibodies | Virus Blockade mAbs

Q: Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show functional activity (PRNT/pseudovirus), whereas binding antibodies may not block infection.

Q: PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT uses infectious virus (gold standard); pseudovirus enables BSL-2 functional readouts; sVNT screens receptor blocking on plates for fast throughput.

Q: How do I interpret IC50/ID50 values?

Lower IC50/ID50 denotes stronger neutralization under matched conditions; compare across the same assay setup only.

abinScience neutralizing antibodies (NAbs) block viral entry or fusion and are validated by PRNT, pseudovirus, or surrogate receptor–ligand blocking (sVNT), with IC50/ID50 titers reported where applicable. Panels span coronaviruses (e.g., RBD/ACE2 blockers), influenza (HA), RSV (F), and arboviruses (DENV/ZIKV/CHIKV). Products provide epitope/mechanism notes, variant/strain coverage, isotype and Fc options (native/engineered), and lot-specific CoAs. RUO

Why Researchers Choose abinScience

Functional Validation PRNT, pseudovirus, sVNT with IC50/ID50

Mechanism Annotated Receptor/fusion/capsid blocking

Variant Coverage Documented on datasheets

Isotype & Fc Options IgG/IgA, effector-on/off

Lot-Specific QC CoA, storage, handling guidance

Shop by Pathogen

Shop by Mechanism

Selection Guide

Assay Readout & Potency: PRNT/pseudovirus for functional titers (IC50/ID50); sVNT for rapid screening. Compare IC50 across matched assay conditions.
Epitope & Mechanism: Choose receptor-blocking (e.g., RBD–ACE2) vs. fusion blockers (e.g., RSV F); confirm neutralization across relevant variants/strains.
Isotype & Fc: IgG for general use; IgA for mucosal models; select native vs. engineered Fc (effector-on/off) to match your MoA study.
Matrix & Format: Prefer unconjugated for neutralization assays; use labeled versions for ELISA/flow tracking.
Controls: Include binding-only mAbs, isotypes, and positive NAb controls to benchmark assay performance.

Applications

Neutralization potency ranking and MoA studies

Vaccine/convalescent serum research and escape-variant assessment

Assay development: PRNT, pseudovirus, sVNT and competitive ELISAs

Documents & QC

Datasheet with assay type (PRNT/pseudovirus/sVNT), IC50 and acceptance criteria

Variant/strain coverage, epitope notes and cross-reactivity

Lot-specific CoA; storage, stability and reconstitution

FAQs

Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show activity in PRNT/pseudovirus assays, while binding antibodies recognize the antigen without necessarily blocking infection.

PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT is the classical infectious-virus gold standard; pseudovirus offers BSL-2 functional readouts; sVNT screens receptor blocking on plates. Choose per biosafety, throughput and MoA.

How do I interpret IC50/ID50 values?

Lower IC50/ID50 indicates stronger neutralization under stated conditions; compare only across matched cell lines, MOI, and incubation protocols.

RUO disclaimer

All antibodies are for Research Use Only and not for diagnostic or therapeutic use.

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BAG3 (1)

EDB & CD3E (1)

CD16/CD32 (1)

FAP/FAPalpha (1)

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A29L (2)

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Spike glycoprotein 2 (5)

DT/Diphtheria toxin (3)

IGF2 (1)

Capsid protein VP2 (2)

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Glycoprotein G (17)

IL11 (1)

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shiga toxin type 2A/stx2A (1)

PA/pagA/PA-83 (2)

CD100/SEMA4D (3)

Hemagglutinin (H7 subtype) (4)

IL21 (1)

FedF (1)

CD295/LEPR (1)

CFD (1)

Rabbit hemorrhagic disease virus (RHDV) Capsid protein (1)

Fc Block (1)

APP/Amyloid beta (1)

PSCA (1)

CD172a/SIRPA (3)

A35R (5)

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IL31RA (1)

ERVW-1/HERV-W-Env (1)

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CXCL13/BCA-1/BLC (1)

SplB (1)

IL22 (1)

IL23A (1)

C1S (1)

F2/Prothrombin/PIVKA-II (1)

RHDV VP60 (1)

IL1A/IL1F1 (1)

DKK1 (2)

CA9 (1)

E1 & E2 (gp35 & gp70) (3)

Protein P (1)

CCL14/NCC-2 (1)

EGFRvIII-specific/EGFR variant III (2)

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TREM1 & CD46 (1)

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TNFa/TNF-alpha (1)

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fimH (1)

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E2s (2)

IL36RN/IL-1F5/IL-36Ra (1)

gH/UL75 (1)

ARG1/Arginase-1 (2)

protruding (P) domain (1)

IL1B/IL1F2 (1)

Virionprotein 1/2/3 (1)

CD137/4-1BB (2)

GP/Envelopment polyprotein (1)

Envelopeglycoprotein E2/gp55 (2)

CCL17/TARC (1)

LRRC15/LIB (1)

PTP4A1/PRL1 (1)

ADAMTS4 (4)

FGF21 (1)

Procapsid [(VP0/1/3) 5] 12 (2)

ANGPTL3 (1)

Major capsid protein L1 (11)

LTA/TNF-beta (1)

CXCL2/GRO-beta/MIP2-alpha (1)

GREM1/DAND2 (1)

PRLR (1)

CD21/CR2 (1)

Spike (5)

IFNA1/Interferon alpha-D (1)

SAA (1)

F8/Coagulation factor VIII (4)

CD16/FCGR3 (1)

P domain (4)

IL2 (1)

Virionprotein 1/VP1 (1)

LGR5/GPR49 (1)

Glycoprotein C/Gc (4)

CD120b/TNFR2 (1)

CCL24/Eotaxin-2/MPIF-2 (1)

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PTP4A3/PRL3 (1)

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Mature virion in Complex [(VP0/1/3)5]12 (2)

APCS/PTX2 (1)

E7/Protein E7 (4)

CSF1/M-CSF (1)

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CD3 (1)

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gp120/Glycoprotein 120 (1)

RSPO3 (1)

SERPINE1/PAI-1 (1)

CD226/DNAM-1 (1)

gp120 (2)

IL5 (1)

ARC (3)

HHRF3/US28 (1)

Dupilumab (2)

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Prefusion Protein (2)

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CSF3/G-CSF (1)

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Tityustoxin VII/Toxin VII/Ts7 (1)

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env/Envpolyprotein (1)

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Envelope protein E (13)

CD62L/SELL (1)

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IL6 (1)

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CD84 (1)

F/fusion protein (2)

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lukF (1)

RBD (Omicron/KP.2) (2)

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CD279/PD-1 (9)

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HSV- gB (1)

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Capsid protein VP25 (2)

mature virion in complex (5)

CD319/SLAMF7 (1)

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stxB/SLT-1b/VT1 (2)

Neuraminidase/NA (4)

p21/Mature core protein (1)

BMP2 (2)

CNR1/CB1 (3)

FOLH1/PSMA (1)

ROBO4 (1)

gp46 (2)

gD/Envelope glycoprotein D (1)

NLRP3 (1)

ANGPTL4 (5)

ACE2 (3)

long-chain neurotoxin (1)

IL12B/IL-12 p40 (1)

CD268/TNFRSF13C (2)

CD228/MELTF (1)

IL11RA (1)

IFN α2/IFNA2 (1)

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env/Envelope protein (1)

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BMP6 (1)

LRP6 (1)

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Envelope glycoprotein GP350 (1)

gE/Envelope glycoprotein E (1)

ProteinUL128 & UL131A (1)

TREML1/TLT1 (1)

CD37/TSPAN26 (2)

short-chain neurotoxin (1)

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Toxin B/tcdB (2)

GFRAL (1)

Fusion glycoprotein (3)

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IFNAR1 (1)

RBD (23)

PODXL (2)

G9&A16 complex (2)

Outer capsid glycoprotein VP7 (1)

UL130 (1)

CD307e/FCRL5 (1)

CD152/CTLA4 (4)

Capsid (1)

IL17F (1)

CD52 (1)

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L1/Major capsid protein L1 (2)

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TSG101 (2)

pro-MSTN/GDF8 (1)

H3L (2)

CCL2/MCP-1 (1)

ROR1/NTRKR1 (1)

SOD1 (1)

Spike glycoprotein E2 (1)

BMP10 (1)

wlaB/pglK (1)

S1 N-terminal domain/S1-NTD (3)

CD48 (1)

gB (2)

Intermediate capsid protein VP6 (1)

Alpha-toxin/hly (3)

APOE (1)

CD309/VEGFR-2 (1)

MERS-CoV RBD (1)

IL17A (4)

CD20/MS4A1 (1)

CD132/IL2RG (1)

CDH11 (1)

NS1/Non-structural protein 1 (1)

VP1/Coatprotein VP1 (2)

TSLP (1)

CD254/RANKL/TNFSF11 (1)

M1R (4)

CCL3/MIP-1-alpha (1)

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G/Major surface glycoprotein G (2)

Spike glycoprotein E1 (2)

GDF11/BMP11 (1)

ALPP/PLAP (1)

entB/SEB (1)

CD198/CCR8 (4)

long-chain α-neurotoxins (1)

Outer capsid protein VP4 (1)

shiga toxin type 1B/stx1B (2)

tetX/Tetanus toxin (1)

Ly6g/Ly-6G.1 (2)

p67 (1)

IL18/IL1F4 (1)

Capsid protein VP1 (2)

CCL1/I-309 (1)

aPC/Activated protein C (3)

InlB/Internalin B (1)

GPA33 (1)

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E8L (2)

CCL5/RANTES (1)

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Major surface glycoprotein G (3)

G/Glycoprotein (5)

IGF1 (1)

Capsid protein VP 1/2/3 (2)

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GPC (18)

Hemagglutinin/HA (1)

GIPR/GIP-R (1)

shiga toxin type 2/stx2B (1)

S/Spike glycoprotein (2)

CD96 (2)

CD124/IL4RA (1)

IL20 (1)

CD283/TLR3 (2)

env/Env polyprotein (4)

Pre-F/Fusion glycoprotein F0 (2)
Species

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Clostridioides difficile (2)

Hantaan virus (HTNV) (2)

Porcine circovirus 2 (PCV2) (2)

Mouse (33)

Reston ebolavirus (REBOV) (1)

Dengue virus type 3 (DENV-3) (1)

Rotavirus (RV) (1)

Human astrovirus-8 (HAtVs) (1)

Coxsackievirus B1 (CBV1) (3)

Chikungunya virus (CHIKV) (1)

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Puumala virus (PUUV) (2)

Rabbit (2)

Bundibugyo ebolavirus (BDBV) (1)

Dengue virus type 4 (DENV-4) (1)

Human metapneumovirus (HMPV) (4)

Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)

Zaire ebolavirus (ZEBOV) (6)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)

Dengue virus type 2 (DENV-2) (8)

Dobrava-Belgrade virus (DOBV) (2)

Human cytomegalovirus (HCMV/HHV-5) (7)

Plasmodium vivax (2)

Human metapneumovirus (2)

Tai Forest ebolavirus (TAFV) (1)

Epstein-Barr virus (EBV/HHV-4) (2)

Machupo virus (MACV) (1)

Varicella-zoster virus (VZV/HHV-3) (4)

Ebola virus (EBOV) (1)

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Enterovirus 71 (EV71) (4)

Seoul virus (SEOV) (2)

Campylobacter jejuni subsp. (1)

Junin mammarenavirus (JUNV) (1)

Sudan ebolavirus (SEBOV) (1)

Andes virus (ANDV) (2)

Hepatitis C Virus (HCV) (9)

E. coli (4)

Hendra virus (HeV) (2)

Human immunodeficiency virus 1 (HIV-1) (9)

Monkey (1)

Sin Nombre virus (SNV) (2)

Human (177)

Clostridium botulinum (2)

Zika virus (ZIKV) (4)

Human adenovirus 3 (HAdV-3) (1)

Bovine respiratory syncytial virus (BRSV) (2)

Rotavirus A (RV-A) (3)

Japanese encephalitis virus (JEV) (1)

Cat (1)

Orthohantavirus puumalaense (PUUV) (1)

Human papillomavirus 58 (HPV58) (3)

Human hepatitis A virus (HHAV) (1)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (22)

Poliovirus type 1 (PV1) (2)

Human papillomavirus 16 (HPV16) (2)

Human papillomavirus 6 (HPV6) (1)

Suid alphaherpesvirus 1 (SuHV-1/PRV) (2)

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Dog (10)

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Rat (1)

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Staphylococcus aureus (3)

Human papillomavirus 59 (HPV59) (1)

Brazilian scorpion (1)

Nipah virus (NiV) (13)

Human endogenous retroviruses W (HERV-W) (1)

Lassa virus (LASV) (1)

Streptococcus pneumoniae (1)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)

Coxsackievirus A16 (CVA16) (2)

Dengue virus type 1 (DENV-1) (1)
Applications

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IF (20)

in vivo (2)

WB (59)

in vivo neutralization (5)

IHC (18)

Blocking (2)

in vivo neutrophil depletion (2)

Antagonist (1)

IP (9)

in vivo CD8+ T cell depletion (1)

in vivo MDSC depletion (2)

in vivo research (1)

Neutralization (706)

Western blot (1)

Cell Isolation (1)

in vivo CTLA-4 neutralization (2)

Cell Depletion (1)

neutralizing (1)

in vivo intra-tumoral regulatory T cell depletion (2)

Nneutralization (1)

ELISA (621)

DB (3)

SPR (46)

in vivo study (1)

in vivo protection (1)

FCM (120)

RIA (1)

NK cell activation (1)

IB (1)

in vitro neutralization (1)

Neutralizatio (1)

FuncS (4)

BLI (4)

ICC (3)
Reactivity

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IgG1b12 (1)

Bovine viral diarrhea virus (BVDV) (2)

Semliki Forest virus (SFV) (1)

Zika virus (ZIKV) (1)

Human papillomavirus 16 (HPV16) (13)

Human metapneumovirus (HMPV) (1)

Influenza A virus (H7N3) (2)

Staphylococcus aureus (3)

Human astrovirus-8 (HAtVs) (1)

Escherichia coli (1)

West Nile virus (WNV) (1)

Human astrovirus-2 (1)

Mouse (25)

Monkeypox virus (MPXV) (12)

Porcine circovirus 2 (PCV2) (1)

Hepatitis C Virus (HCV) (43)

Influenza A virus (H7N9) (1)

Klebsiella pneumoniae (1)

Coxsackievirus B1 (CVB1) (3)

MERS-CoV (2)

Vesicular stomatitis Indiana virus (VSIV) (2)

Chikungunya virus (1)

Bacillus anthracis (2)

HAstV-1 (2)

Measles virus (MeV) (2)

Lassa virus (LASV) (16)

Human enterovirus 71 (EV71) (3)

Guertu Virus (GTV) (3)

Monkey (1)

Hepatitis E virus/HEV (3)

SARS-CoV (1)

Monkeypox virus (5)

Sin Nombre Virus (1)

Murine norovirus 1 (MNV) (1)

Clostridium botulinum (1)

Heartland Virus (HRTV) (1)

SARS-CoV-2 (1)

Theileria parva (1)

Japanese encephalitis virus (JEV) (2)

Mexican scorpion (3)

Junin mammarenavirus (JUNV) (3)

Dengue virus (1)

Homo sapiens (Human) (1)

Naja kaouthia (1)

Foot-and-mouth disease virus (FMDV) (2)

Human (57)

HCoV-229E (2)

Human cytomegalovirus (HCMV/HHV-5) (1)

Poliovirus type 1 (PV1) (1)

Norwalk virus (3)

Machupo virus (MACV) (1)

Zika virus (1)

Crimean-Congo hemorrhagic fever virus (2)

Clostridium perfringens (3)

Venezuelan equine encephalitis virus (VEEV) (1)

Norwalk virus (NV) (5)

Dengue Virus type 1 (DENV-1) (1)

Epstein-Barr virus (EBV/HHV-4) (3)

Rat (5)

HCoV-OC43 (1)

RD114 retrovirus (1)

Human T-cell leukemia virus 1 (HTLV-1) (2)

Coxsackievirus A16 (CVA16) (3)

Human coronavirus HKU1 (HCoV-HKU1) (1)

HSV-1 (3)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (1)

Listeria monocytogenes (1)

Chikungunya virus (CHIKV) (4)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (8)

Western equine encephalitis virus (WEEV) (1)

Dengue Virus type 2 (DENV-2) (1)

Human respiratory syncytial virus (HRSV) (5)

Rabies virus (RABV) (6)

HCoV-NL63 (1)

Influenza A virus H7 subtype (2)

Corynephage omega (3)

HIV-1 (1)

Clostridium tetani (1)

HSV-2 (3)

Scorpion (2)

Canine parvovirus (1)

Mayaro virus(MAYV) (1)

Eastern equine encephalitis virus (EEEV) (1)

Rabbit hemorrhagic disease virus (RHDV) GI.2 (1)

Vaccinia virus (VACV) (20)

Dengue Virus type 3 (DENV-3) (1)

Puumala virus (1)

Hepatitis E virus (2)

Hendra virus (1)

Bacteriophage H19B (2)

Clostridioides difficile (2)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (5)

Influenza B virus (2)

Tick-borne encephalitis virus (1)

Parainfluenza virus 5 (PIV5) (1)

Ross River Virus (RRV) (2)

O’nyong’nyong virus (ONNV) (1)

Dengue Virus type 4 (DENV-4) (1)

Nipah virus (1)

Influenza A virus (1)

Hendra virus (HeV) (12)

E. coli (1)

O'nyong'nyong virus (ONNV) (1)

Streptococcus equisimilis (1)

Yellow Fever Virus (YFV) (1)

Pig (1)

Influenza A virus (H7N1) (1)

Epstein-Barr virus (HHV-4) (Human herpesvirus 4) (1)

Nipah virus (NiV) (13)

Ophiophagus hannah (1)

severe fever with thrombocytopenia syndrome virus (SFTSV) (8)
Host species

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Rat (10)

Alpaca (23)

Mouse (215)

Rabbit (2)

Cat (1)

Human (463)

Dog (8)
Clonality

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Monoclonal (727)
Conjugate

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Unconjugated (727)