All antibodies are for Research Use Only (RUO) and not for diagnostic or therapeutic use.

Neutralizing Antibodies | Virus Blockade mAbs

Q: Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show functional activity (PRNT/pseudovirus), whereas binding antibodies may not block infection.

Q: PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT uses infectious virus (gold standard); pseudovirus enables BSL-2 functional readouts; sVNT screens receptor blocking on plates for fast throughput.

Q: How do I interpret IC50/ID50 values?

Lower IC50/ID50 denotes stronger neutralization under matched conditions; compare across the same assay setup only.

abinScience neutralizing antibodies (NAbs) block viral entry or fusion and are validated by PRNT, pseudovirus, or surrogate receptor–ligand blocking (sVNT), with IC50/ID50 titers reported where applicable. Panels span coronaviruses (e.g., RBD/ACE2 blockers), influenza (HA), RSV (F), and arboviruses (DENV/ZIKV/CHIKV). Products provide epitope/mechanism notes, variant/strain coverage, isotype and Fc options (native/engineered), and lot-specific CoAs. RUO

Why Researchers Choose abinScience

Functional Validation PRNT, pseudovirus, sVNT with IC50/ID50

Mechanism Annotated Receptor/fusion/capsid blocking

Variant Coverage Documented on datasheets

Isotype & Fc Options IgG/IgA, effector-on/off

Lot-Specific QC CoA, storage, handling guidance

Shop by Pathogen

Shop by Mechanism

Selection Guide

Assay Readout & Potency: PRNT/pseudovirus for functional titers (IC50/ID50); sVNT for rapid screening. Compare IC50 across matched assay conditions.
Epitope & Mechanism: Choose receptor-blocking (e.g., RBD–ACE2) vs. fusion blockers (e.g., RSV F); confirm neutralization across relevant variants/strains.
Isotype & Fc: IgG for general use; IgA for mucosal models; select native vs. engineered Fc (effector-on/off) to match your MoA study.
Matrix & Format: Prefer unconjugated for neutralization assays; use labeled versions for ELISA/flow tracking.
Controls: Include binding-only mAbs, isotypes, and positive NAb controls to benchmark assay performance.

Applications

Neutralization potency ranking and MoA studies

Vaccine/convalescent serum research and escape-variant assessment

Assay development: PRNT, pseudovirus, sVNT and competitive ELISAs

Documents & QC

Datasheet with assay type (PRNT/pseudovirus/sVNT), IC50 and acceptance criteria

Variant/strain coverage, epitope notes and cross-reactivity

Lot-specific CoA; storage, stability and reconstitution

FAQs

Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show activity in PRNT/pseudovirus assays, while binding antibodies recognize the antigen without necessarily blocking infection.

PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT is the classical infectious-virus gold standard; pseudovirus offers BSL-2 functional readouts; sVNT screens receptor blocking on plates. Choose per biosafety, throughput and MoA.

How do I interpret IC50/ID50 values?

Lower IC50/ID50 indicates stronger neutralization under stated conditions; compare only across matched cell lines, MOI, and incubation protocols.

RUO disclaimer

All antibodies are for Research Use Only and not for diagnostic or therapeutic use.

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env/Envpolyprotein (1)

CD124/IL4RA (1)

IL31 (4)

gp32/gp35/Envelope glycoprotein E1 (1)

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A27L (5)

lukF (1)

CLDN3/Claudin-3 (1)

protruding (P) domain (1)

gp46 (2)

IL38/IL1F10 (2)

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HGF (1)

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pro-MSTN/GDF8 (1)

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A33R (2)

RBD (Omicron/KP.2) (2)

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FGF21 (1)

shiga toxin type 1B/stx1B (2)

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GDF11/BMP11 (1)

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Pre-F/Fusion glycoprotein F0 (2)

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CD96 (2)

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CD226/DNAM-1 (1)

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G/Major surface glycoprotein G (2)

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CD37/TSPAN26 (2)

Procapsid [(VP0/1/3) 5] 12 (2)

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Capsid protein VP 1/2/3 (2)

GPRC5D (1)

CD52 (1)

E1 & E2 (gp35 & gp70) (3)

CD295/LEPR (1)

CCL1/I-309 (1)

THPO/Thrombopoietin (1)

Tityustoxin VII/Toxin VII/Ts7 (1)

TNFSF9/4-1BBL (2)

BDNF (1)

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Mature virion in Complex [(VP0/1/3)5]12 (2)

BLLF1/MA/GP350 (1)

CXCL10/IP-10 (1)

Spike glycoprotein E2 (1)

ROBO2 (1)

Envelopeglycoprotein E2/gp55 (2)

HSV- gB (1)

CXCL12/SDF-1 (1)

CD337/NCR3/NKp30 (1)

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IL13 (1)

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CD309/VEGFR-2 (1)

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ERVW-1/HERV-W-Env (1)

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gp120 (2)

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Gn (9)

RSPO3 (1)

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F2/Prothrombin/PIVKA-II (1)

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MERS-CoV RBD (1)

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CDH11 (1)

Ly6g/Ly-6G.1 (2)

G9&A16 complex (2)

short-chain neurotoxin (1)

EGFRvIII-specific/EGFR variant III (2)

Protein prM/prM (3)

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Hepacivirin/NS3P/Viroporin p70 (3)

CNR1/CB1 (3)

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gp125 (1)

shiga toxin type 2/stx2B (1)

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Fusion glycoprotein F0 (5)

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IL6 (1)

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CD132/IL2RG (1)

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S/Spike glycoprotein (2)

L1R/Protein L1 (4)

CD279/PD-1 (9)

VTCN1/B7-H4 (1)

CD120b/TNFR2 (1)

gE/Envelope glycoprotein E (1)

GPA33 (1)

SERPINE1/PAI-1 (1)

CCL11/Eotaxin (1)

SNCA/Alpha-synuclein (5)

CD137/4-1BB (2)

IFNA1/Interferon alpha-D (1)

S1 N-terminal domain/S1-NTD (3)

F12/Coagulationfactor XII (1)

Spike glycoprotein 2 (5)

shiga toxin type 2A/stx2A (1)

DPEP3 (1)

IL23A (1)

SOD1 (1)

CD100/SEMA4D (3)

CXCL11/I-TAC (1)

NS1/gp68/gp70 (40)

OSM/Oncostatin-M (1)

IL21 (1)

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CSF1/M-CSF (1)

S2 Protein (3)

Hemagglutinin/HA (1)

RHDV VP60 (1)

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IFNG/IFN-gamma (2)

Protein P (1)

CXCL4/PF4 (1)

Glycoprotein (1)

LAMP5 (2)

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CTGF/CCN2 (1)

RBD (Omicron/JN.1) (2)

mature virion in complex (5)

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Spike glycoprotein E1 (2)

CCL2/MCP-1 (1)

H3L (2)

SAA (1)

Fusion glycoprotein (3)

CD48 (1)

E-DII (1)

env/Env polyprotein (4)

DKK1 (2)

BMP4 (1)

FOLH1/PSMA (1)

NLRP3 (1)

P domain (4)

IFN α2/IFNA2 (1)
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Bovine respiratory syncytial virus (BRSV) (2)

Rabbit (2)

Enterovirus 71 (EV71) (4)

Varicella-zoster virus (VZV/HHV-3) (4)

Hendra virus (HeV) (2)

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Brazilian scorpion (1)

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Human papillomavirus 6 (HPV6) (1)

Human astrovirus-8 (HAtVs) (1)

Human hepatitis A virus (HHAV) (1)

Puumala virus (PUUV) (2)

Reston ebolavirus (REBOV) (1)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)

Dobrava-Belgrade virus (DOBV) (2)

Human adenovirus 3 (HAdV-3) (1)

Human respiratory syncytial virus (HRSV) (12)

Bundibugyo ebolavirus (BDBV) (1)

Human immunodeficiency virus 1 (HIV-1) (9)

Human papillomavirus 16 (HPV16) (2)

Seoul virus (SEOV) (2)

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Human papillomavirus 58 (HPV58) (3)

Streptococcus pneumoniae (1)

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Rat (1)

Plasmodium vivax (2)

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Tai Forest ebolavirus (TAFV) (1)

Clostridium botulinum (2)

Ebola virus (EBOV) (1)

Japanese encephalitis virus (JEV) (1)

Andes virus (ANDV) (2)

Epstein-Barr virus (EBV/HHV-4) (2)

Human papillomavirus 59 (HPV59) (1)

Porcine circovirus 2 (PCV2) (2)

Dengue virus type 2 (DENV-2) (8)

E. coli (4)

Monkey (1)

Human endogenous retroviruses W (HERV-W) (1)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)

Rotavirus (RV) (1)

Sudan ebolavirus (SEBOV) (1)

Clostridioides difficile (2)

Sin Nombre virus (SNV) (2)

Lassa virus (LASV) (1)

Rotavirus A (RV-A) (3)

Dengue virus type 1 (DENV-1) (1)

Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)

Cat (1)

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Poliovirus type 1 (PV1) (2)

Nipah virus (NiV) (13)

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Mouse (33)

Human (177)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (22)

Dengue virus type 3 (DENV-3) (1)

Hepatitis C Virus (HCV) (9)

Coxsackievirus A16 (CVA16) (2)

Human metapneumovirus (HMPV) (4)

Hepatitis E virus/HEV (1)

Zaire ebolavirus (ZEBOV) (6)

Dengue virus type 4 (DENV-4) (1)

Suid alphaherpesvirus 1 (SuHV-1/PRV) (2)

Human herpesvirus 1 (HSV-1/HHV-1) (3)

Influenza A virus (Flu A) (5)

Staphylococcus aureus (3)

Campylobacter jejuni subsp. (1)

Human parvovirus B19 (HPV B19) (3)

Hantaan virus (HTNV) (2)
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Cell Isolation (1)

RIA (1)

in vivo CD8+ T cell depletion (1)

ELISA (620)

Cell Depletion (1)

Western blot (1)

WB (59)

SPR (46)

FuncS (4)

Antagonist (1)

in vivo research (1)

ICC (3)

in vivo protection (1)

NK cell activation (1)

Nneutralization (1)

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in vivo neutrophil depletion (2)

in vitro neutralization (1)

neutralizing (1)

FCM (120)

in vivo study (1)

BLI (4)

in vivo MDSC depletion (2)

in vivo CTLA-4 neutralization (2)

IF (22)

in vivo intra-tumoral regulatory T cell depletion (2)

Neutralizatio (1)

DB (3)

IHC (18)

Blocking (2)

IP (9)

in vivo (2)

Neutralization (705)

in vivo neutralization (5)
Reactivity

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (5)

Influenza A virus H7 subtype (2)

HSV-1 (3)

Hendra virus (HeV) (12)

Escherichia coli (1)

Theileria parva (1)

Human astrovirus-2 (1)

Hendra virus (1)

Staphylococcus aureus (3)

Dengue Virus type 1 (DENV-1) (1)

Mexican scorpion (3)

RD114 retrovirus (1)

Guertu Virus (GTV) (3)

Human enterovirus 71 (EV71) (3)

HSV-2 (3)

HCoV-229E (2)

HAstV-1 (2)

Influenza A virus (H7N3) (2)

Norwalk virus (3)

Klebsiella pneumoniae (1)

Dengue virus (1)

Epstein-Barr virus (EBV/HHV-4) (3)

Ophiophagus hannah (1)

Nipah virus (1)

Bacillus anthracis (2)

Dengue Virus type 2 (DENV-2) (1)

Coxsackievirus B1 (CVB1) (3)

Crimean-Congo hemorrhagic fever virus (2)

Rabies virus (RABV) (6)

Measles virus (MeV) (2)

Homo sapiens (Human) (1)

Bacteriophage H19B (2)

Clostridium tetani (1)

Heartland Virus (HRTV) (1)

Rat (5)

Influenza A virus (H7N9) (1)

HIV-1 (1)

Listeria monocytogenes (1)

Zika virus (1)

Naja kaouthia (1)

Mayaro virus(MAYV) (1)

Clostridium perfringens (3)

Dengue Virus type 3 (DENV-3) (1)

Clostridium botulinum (1)

Coxsackievirus A16 (CVA16) (3)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (8)

Human respiratory syncytial virus (HRSV) (5)

Canine parvovirus (1)

Japanese encephalitis virus (JEV) (2)

O'nyong'nyong virus (ONNV) (1)

SARS-CoV (1)

Venezuelan equine encephalitis virus (VEEV) (1)

Nipah virus (NiV) (13)

Poliovirus type 1 (PV1) (1)

Dengue Virus type 4 (DENV-4) (1)

Human (57)

Murine norovirus 1 (MNV) (1)

Semliki Forest virus (SFV) (1)

SARS-CoV-2 (1)

Bovine viral diarrhea virus (BVDV) (2)

Tick-borne encephalitis virus (1)

E. coli (1)

Corynephage omega (3)

Western equine encephalitis virus (WEEV) (1)

IgG1b12 (1)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (1)

Clostridioides difficile (2)

Yellow Fever Virus (YFV) (1)

Chikungunya virus (1)

severe fever with thrombocytopenia syndrome virus (SFTSV) (8)

Influenza B virus (2)

Human cytomegalovirus (HCMV/HHV-5) (1)

MERS-CoV (2)

Monkeypox virus (5)

Influenza A virus (H7N1) (1)

Vaccinia virus (VACV) (20)

Eastern equine encephalitis virus (EEEV) (1)

Human papillomavirus 16 (HPV16) (13)

Rabbit hemorrhagic disease virus (RHDV) GI.2 (1)

Human astrovirus-8 (HAtVs) (1)

Zika virus (ZIKV) (1)

Foot-and-mouth disease virus (FMDV) (2)

Streptococcus equisimilis (1)

Pig (1)

Human coronavirus HKU1 (HCoV-HKU1) (1)

HCoV-OC43 (1)

Sin Nombre Virus (1)

Junin mammarenavirus (JUNV) (3)

Ross River virus (RRV) (2)

Parainfluenza virus 5 (PIV5) (1)

Mouse (25)

Chikungunya virus (CHIKV) (4)

Monkeypox virus (MPXV) (12)

West Nile virus (WNV) (1)

Scorpion (2)

Hepatitis E virus (2)

Vesicular stomatitis Indiana virus (VSIV) (2)

Lassa virus (LASV) (16)

HCoV-NL63 (1)

Hepatitis E virus/HEV (3)

Machupo virus (MACV) (1)

Norwalk virus (NV) (5)

O’nyong’nyong virus (ONNV) (1)

Human T-cell leukemia virus 1 (HTLV-1) (2)

Epstein-Barr virus (HHV-4) (Human herpesvirus 4) (1)

Puumala virus (1)

Porcine circovirus 2 (PCV2) (1)

Hepatitis C Virus (HCV) (43)

Human metapneumovirus (HMPV) (1)

Monkey (1)
Host species

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Rabbit (2)

Cat (1)

Human (462)

Mouse (215)

Alpaca (23)

Rat (10)

Dog (8)
Clonality

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Monoclonal (726)
Conjugate

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Unconjugated (726)