All antibodies are for Research Use Only (RUO) and not for diagnostic or therapeutic use.

Neutralizing Antibodies | Virus Blockade mAbs

Q: Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show functional activity (PRNT/pseudovirus), whereas binding antibodies may not block infection.

Q: PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT uses infectious virus (gold standard); pseudovirus enables BSL-2 functional readouts; sVNT screens receptor blocking on plates for fast throughput.

Q: How do I interpret IC50/ID50 values?

Lower IC50/ID50 denotes stronger neutralization under matched conditions; compare across the same assay setup only.

abinScience neutralizing antibodies (NAbs) block viral entry or fusion and are validated by PRNT, pseudovirus, or surrogate receptor–ligand blocking (sVNT), with IC50/ID50 titers reported where applicable. Panels span coronaviruses (e.g., RBD/ACE2 blockers), influenza (HA), RSV (F), and arboviruses (DENV/ZIKV/CHIKV). Products provide epitope/mechanism notes, variant/strain coverage, isotype and Fc options (native/engineered), and lot-specific CoAs. RUO

Why Researchers Choose abinScience

Functional Validation PRNT, pseudovirus, sVNT with IC50/ID50

Mechanism Annotated Receptor/fusion/capsid blocking

Variant Coverage Documented on datasheets

Isotype & Fc Options IgG/IgA, effector-on/off

Lot-Specific QC CoA, storage, handling guidance

Shop by Pathogen

Shop by Mechanism

Selection Guide

Assay Readout & Potency: PRNT/pseudovirus for functional titers (IC50/ID50); sVNT for rapid screening. Compare IC50 across matched assay conditions.
Epitope & Mechanism: Choose receptor-blocking (e.g., RBD–ACE2) vs. fusion blockers (e.g., RSV F); confirm neutralization across relevant variants/strains.
Isotype & Fc: IgG for general use; IgA for mucosal models; select native vs. engineered Fc (effector-on/off) to match your MoA study.
Matrix & Format: Prefer unconjugated for neutralization assays; use labeled versions for ELISA/flow tracking.
Controls: Include binding-only mAbs, isotypes, and positive NAb controls to benchmark assay performance.

Applications

Neutralization potency ranking and MoA studies

Vaccine/convalescent serum research and escape-variant assessment

Assay development: PRNT, pseudovirus, sVNT and competitive ELISAs

Documents & QC

Datasheet with assay type (PRNT/pseudovirus/sVNT), IC50 and acceptance criteria

Variant/strain coverage, epitope notes and cross-reactivity

Lot-specific CoA; storage, stability and reconstitution

FAQs

Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show activity in PRNT/pseudovirus assays, while binding antibodies recognize the antigen without necessarily blocking infection.

PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT is the classical infectious-virus gold standard; pseudovirus offers BSL-2 functional readouts; sVNT screens receptor blocking on plates. Choose per biosafety, throughput and MoA.

How do I interpret IC50/ID50 values?

Lower IC50/ID50 indicates stronger neutralization under stated conditions; compare only across matched cell lines, MOI, and incubation protocols.

RUO disclaimer

All antibodies are for Research Use Only and not for diagnostic or therapeutic use.

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Antibodies (727)
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STEAP1 (1)

Hepacivirin/NS3P/Viroporin p70 (3)

ACVRL1/ALK-1 (1)

Pre-F/Fusion glycoprotein F0 (2)

SplB (1)

CNR1/CB1 (3)

CD96 (2)

PTP4A1/PRL1 (1)

CXCL1/NAP-3/GRO-alpha (1)

Glycoprotein G (17)

CD226/DNAM-1 (1)

IL31RA (1)

APOE (1)

ROR1/NTRKR1 (1)

Intermediate capsid protein VP6 (1)

RBD (S6P trimer) (3)

G/Major surface glycoprotein G (2)

LRRC15/LIB (1)

CCL14/NCC-2 (1)

aPC/Activated protein C (3)

LGR5/GPR49 (1)

p67 (1)

CD21/CR2 (1)

AFP/Alpha-fetoprotein (1)

CD37/TSPAN26 (2)

Procapsid [(VP0/1/3) 5] 12 (2)

CD222/IGF2R (1)

gH/gL Complexes (2)

Rabbit hemorrhagic disease virus (RHDV) Capsid protein (1)

Capsid protein VP2 (2)

L1R/Protein L1 (4)

IL12B/IL-12 p40 (1)

Galectin-3/Gal-3 (1)

Capsid protein VP 1/2/3 (2)

GPRC5D (1)

CD52 (1)

E1 & E2 (gp35 & gp70) (3)

CD295/LEPR (1)

CCL1/I-309 (1)

THPO/Thrombopoietin (1)

Tityustoxin VII/Toxin VII/Ts7 (1)

TNFSF9/4-1BBL (2)

CD268/TNFRSF13C (2)

GP/Envelopment polyprotein (1)

L1/Major capsid protein L1 (2)

IGF2 (1)

CD49d/ITGA4 (1)

Capsid protein VP25 (2)

E8L (2)

long-chain α-neurotoxins (1)

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ADAMTS4 (4)

OPN/SPP1 (1)

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gB (2)

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Spike (5)

CXCL9/MIG (1)

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fimH (1)

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WNT2 (4)

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IL10 (1)

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BMP6 (1)

IL11RA (1)

Toxin A/tcdA (2)

tetX/Tetanus toxin (1)

LRP6 (1)

A27L (5)

RBP2b (1)

protruding (P) domain (1)

IL38/IL1F10 (2)

NGF/Beta-NGF (2)

Major surface glycoprotein G (3)

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long-chain neurotoxin (1)

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gH/UL75 (1)

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IL8/CXCL8 (1)

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Major capsid protein L1 (11)

iga/IgA1 protease (1)

gp140/Env Trimer (2)

TSHR/LGR3 (2)

PDGFD (1)

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F/Fusion glycoprotein F0 (16)

CX3CL1/Fractalkine (1)

PSCA (1)

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CCL17/TARC (1)

EDB & CD3E (1)

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Envelope protein E (13)

env/Envelope protein (1)

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gB/BALF4 (2)

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ProteinUL128 & UL131A (1)

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Mature virion in Complex [(VP0/1/3)5]12 (2)

gH/BXLF2 (2)

CXCL10/IP-10 (1)

ROBO2 (1)

HSV- gB (1)

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Fusion glycoprotein/F Trimer (1)

IL13 (1)

CD309/VEGFR-2 (1)

RAGE/AGER (1)

ERVW-1/HERV-W-Env (1)

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RBD (23)

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Outer capsid protein VP4 (1)

gp120 (2)

Heparanase (1)

stxB/SLT-1b/VT1 (2)

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GFRAL (1)

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IL17C (1)

E6/Protein E6 (1)

LTA/TNF-beta (1)

GPC (18)

A35R (5)

Outer capsid glycoprotein VP7 (1)

Dupilumab (2)

gH/Envelope glycoprotein H (1)

CDH11 (1)

Ly6g/Ly-6G.1 (2)

G9&A16 complex (2)

short-chain neurotoxin (1)

EGFRvIII-specific/EGFR variant III (2)

Protein prM/prM (3)

CD227/MUC1 (1)

InlB/Internalin B (1)

H3L/Ag35 (2)

VTCN1/B7-H4 (1)

CD120b/TNFR2 (1)

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gp125 (1)

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shiga toxin type 2/stx2B (1)

Capsid protein VP1 (2)

IL1A/IL1F1 (1)

TSG101 (2)

Fusion glycoprotein F0 (5)

VLP (1)

IL6 (1)

Genome polyprotein (5)

botA/BOTOX (1)

ACE2 (3)

CD132/IL2RG (1)

SLC39A6/LIV-1 (1)

ALPP/PLAP (1)

S/Spike glycoprotein (2)

Virionprotein 1/2/3 (1)

CD279/PD-1 (9)

CXCL4/PF4 (1)

gE/Envelope glycoprotein E (1)

GPA33 (1)

CCL11/Eotaxin (1)

CD137/4-1BB (2)

IFNA1/Interferon alpha-D (1)

S1 N-terminal domain/S1-NTD (3)

F12/Coagulationfactor XII (1)

Spike glycoprotein 2 (5)

shiga toxin type 2A/stx2A (1)

DPEP3 (1)

IL23A (1)

CD100/SEMA4D (3)

CXCL11/I-TAC (1)

NS1/gp68/gp70 (40)

OSM/Oncostatin-M (1)

IL21 (1)

CSF1/M-CSF (1)

S2 Protein (3)

Hemagglutinin/HA (1)

p21/Mature core protein (1)

IFNG/IFN-gamma (2)

LAMP5 (2)

CTGF/CCN2 (1)

RBD (Omicron/JN.1) (2)

mature virion in complex (5)

A29L (2)

CD198/CCR8 (4)

Spike glycoprotein E1 (2)

Capsid protein VP3 (1)

D8L (2)

CCL2/MCP-1 (1)

SAA (1)

Fusion glycoprotein (3)

CD48 (1)

env/Env polyprotein (4)

DKK1 (2)

BMP4 (1)

APP/Amyloid beta (1)

FOLH1/PSMA (1)

P domain (4)

IFN α2/IFNA2 (1)

Virionprotein 1/VP1 (1)

IL36RN/IL-1F5/IL-36Ra (1)

env/Envpolyprotein (1)

CD124/IL4RA (1)

IL31 (4)

Envelope glycoprotein GP350 (1)

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E2s (2)

IFNAR1 (1)

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ADM/Adrenomedullin (1)

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CD274/PD-L1 (2)

GP/Glycoprotein (5)

IL20 (1)

CA9 (1)

Envelopeglycoprotein E2/gp55 (2)

sLea/CA19-9 (1)

CD73/NT5E (2)

CD337/NCR3/NKp30 (1)

GP1 (2)

CD84 (1)

ENT2/SLC29A2 (1)

gB/UL27 (1)

ANGPTL3 (1)

Structural polyprotein (1)

DT/Diphtheria toxin (3)

CD62L/SELL (1)

Neuraminidase/NA (4)

lukF (1)

CLDN3/Claudin-3 (1)

gp46 (2)

CD40/TNFRSF5 (1)

HGF (1)

MERS-CoV RBD (1)

Alpha-toxin/hly (3)

CSF2/GM-CSF (1)

CD205/LY75/DEC-205 (1)

IGF1 (1)

wlaB/pglK (1)

MUC5AC (1)

ROBO4 (1)

pro-MSTN/GDF8 (1)

CDH17/Cadherin-17 (1)

RBD (Omicron/KP.2) (2)

NS1/Non-structural protein 1 (1)

FGF21 (1)

shiga toxin type 1B/stx1B (2)

GDF11/BMP11 (1)

PDGFC (1)
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Reston ebolavirus (REBOV) (1)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)

Human adenovirus 3 (HAdV-3) (1)

Dobrava-Belgrade virus (DOBV) (2)

Human respiratory syncytial virus (HRSV) (12)

Bundibugyo ebolavirus (BDBV) (1)

Human immunodeficiency virus 1 (HIV-1) (9)

Human papillomavirus 16 (HPV16) (2)

Seoul virus (SEOV) (2)

Human cytomegalovirus (HCMV/HHV-5) (7)

Human papillomavirus 58 (HPV58) (3)

Streptococcus pneumoniae (1)

Coxsackievirus B1 (CBV1) (3)

Rat (1)

Plasmodium vivax (2)

Machupo virus (MACV) (1)

Tai Forest ebolavirus (TAFV) (1)

Clostridium botulinum (2)

Ebola virus (EBOV) (1)

E. coli (4)

Japanese encephalitis virus (JEV) (1)

Andes virus (ANDV) (2)

Epstein-Barr virus (EBV/HHV-4) (2)

Human papillomavirus 59 (HPV59) (1)

Porcine circovirus 2 (PCV2) (2)

Dengue virus type 2 (DENV-2) (8)

Sudan ebolavirus (SEBOV) (1)

Monkey (1)

Human endogenous retroviruses W (HERV-W) (1)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)

Rotavirus (RV) (1)

Clostridioides difficile (2)

Sin Nombre virus (SNV) (2)

Zika virus (ZIKV) (4)

Lassa virus (LASV) (1)

Rotavirus A (RV-A) (3)

Dengue virus type 1 (DENV-1) (1)

Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)

Cat (1)

Human (177)

Poliovirus type 1 (PV1) (2)

Nipah virus (NiV) (13)

Chikungunya virus (CHIKV) (1)

Mouse (33)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (22)

Dengue virus type 3 (DENV-3) (1)

Hepatitis C Virus (HCV) (9)

Coxsackievirus A16 (CVA16) (2)

Human metapneumovirus (HMPV) (4)

Hepatitis E virus/HEV (1)

Zaire ebolavirus (ZEBOV) (6)

Dengue virus type 4 (DENV-4) (1)

Suid alphaherpesvirus 1 (SuHV-1/PRV) (2)

Human herpesvirus 1 (HSV-1/HHV-1) (3)

Influenza A virus (Flu A) (5)

Staphylococcus aureus (3)

Hantaan virus (HTNV) (2)

Campylobacter jejuni subsp. (1)

Human parvovirus B19 (HPV B19) (3)

Human metapneumovirus (2)

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Rabbit (2)

Enterovirus 71 (EV71) (4)

Varicella-zoster virus (VZV/HHV-3) (4)

Hendra virus (HeV) (2)

Junin mammarenavirus (JUNV) (1)

Human hepatitis A virus (HHAV) (1)

Puumala virus (PUUV) (2)

Dog (10)

Brazilian scorpion (1)

Orthohantavirus puumalaense (PUUV) (1)

Human papillomavirus 6 (HPV6) (1)

Human astrovirus-8 (HAtVs) (1)
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Cell Depletion (1)

Western blot (1)

WB (59)

SPR (46)

FuncS (4)

Antagonist (1)

in vivo research (1)

ICC (3)

in vivo protection (1)

NK cell activation (1)

Nneutralization (1)

in vivo neutrophil depletion (2)

in vitro neutralization (1)

FCM (120)

in vivo study (1)

BLI (4)

in vivo MDSC depletion (2)

in vivo CTLA-4 neutralization (2)

in vivo intra-tumoral regulatory T cell depletion (2)

Neutralizatio (1)

DB (3)

IF (22)

IB (1)

IHC (18)

Blocking (2)

IP (9)

neutralizing (1)

in vivo (2)

Neutralization (706)

in vivo neutralization (5)

Cell Isolation (1)

RIA (1)

in vivo CD8+ T cell depletion (1)

ELISA (621)
Reactivity

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Nipah virus (1)

Parainfluenza virus 5 (PIV5) (1)

Pig (1)

HSV-2 (3)

HCoV-229E (2)

HAstV-1 (2)

Influenza A virus (H7N3) (2)

Norwalk virus (3)

Klebsiella pneumoniae (1)

Ophiophagus hannah (1)

Scorpion (2)

Coxsackievirus B1 (CVB1) (3)

Crimean-Congo hemorrhagic fever virus (2)

Rabies virus (RABV) (6)

Monkeypox virus (MPXV) (12)

Measles virus (MeV) (2)

West Nile virus (WNV) (1)

Clostridium tetani (1)

Heartland Virus (HRTV) (1)

Rat (5)

Vesicular stomatitis Indiana virus (VSIV) (2)

Lassa virus (LASV) (16)

Influenza A virus (H7N9) (1)

HIV-1 (1)

Naja kaouthia (1)

Canine parvovirus (1)

Monkey (1)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (8)

Human respiratory syncytial virus (HRSV) (5)

SARS-CoV (1)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (5)

Venezuelan equine encephalitis virus (VEEV) (1)

Hendra virus (HeV) (12)

RD114 retrovirus (1)

Nipah virus (NiV) (13)

Dengue Virus type 1 (DENV-1) (1)

Mexican scorpion (3)

Human (57)

Epstein-Barr virus (EBV/HHV-4) (3)

SARS-CoV-2 (1)

Tick-borne encephalitis virus (1)

Western equine encephalitis virus (WEEV) (1)

Influenza A virus (1)

Porcine circovirus 2 (PCV2) (1)

IgG1b12 (1)

Dengue virus (1)

Bacteriophage H19B (2)

Clostridioides difficile (2)

Bacillus anthracis (2)

Dengue Virus type 2 (DENV-2) (1)

Chikungunya virus (1)

severe fever with thrombocytopenia syndrome virus (SFTSV) (8)

Influenza B virus (2)

Homo sapiens (Human) (1)

Human cytomegalovirus (HCMV/HHV-5) (1)

Mayaro virus(MAYV) (1)

MERS-CoV (2)

Monkeypox virus (5)

Influenza A virus (H7N1) (1)

Vaccinia virus (VACV) (20)

Eastern equine encephalitis virus (EEEV) (1)

Listeria monocytogenes (1)

Zika virus (1)

Japanese encephalitis virus (JEV) (2)

Clostridium perfringens (3)

Dengue Virus type 3 (DENV-3) (1)

Foot-and-mouth disease virus (FMDV) (2)

Clostridium botulinum (1)

Coxsackievirus A16 (CVA16) (3)

Human coronavirus HKU1 (HCoV-HKU1) (1)

O'nyong'nyong virus (ONNV) (1)

HCoV-OC43 (1)

Sin Nombre Virus (1)

Junin mammarenavirus (JUNV) (3)

Ross River virus (RRV) (2)

Murine norovirus 1 (MNV) (1)

Mouse (25)

Chikungunya virus (CHIKV) (4)

Poliovirus type 1 (PV1) (1)

Dengue Virus type 4 (DENV-4) (1)

Epstein-Barr virus (HHV-4) (Human herpesvirus 4) (1)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (1)

Hepatitis E virus (2)

Semliki Forest virus (SFV) (1)

HCoV-NL63 (1)

Bovine viral diarrhea virus (BVDV) (2)

Hepatitis E virus/HEV (3)

Machupo virus (MACV) (1)

Norwalk virus (NV) (5)

E. coli (1)

O’nyong’nyong virus (ONNV) (1)

Corynephage omega (3)

Human T-cell leukemia virus 1 (HTLV-1) (2)

Yellow Fever Virus (YFV) (1)

Puumala virus (1)

Hepatitis C Virus (HCV) (43)

Human metapneumovirus (HMPV) (1)

Hendra virus (1)

Staphylococcus aureus (3)

Influenza A virus H7 subtype (2)

HSV-1 (3)

Escherichia coli (1)

Theileria parva (1)

Human astrovirus-2 (1)

Human papillomavirus 16 (HPV16) (13)

Rabbit hemorrhagic disease virus (RHDV) GI.2 (1)

Human enterovirus 71 (EV71) (3)

Human astrovirus-8 (HAtVs) (1)

Zika virus (ZIKV) (1)

Streptococcus equisimilis (1)

Guertu Virus (GTV) (3)
Host species

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Cat (1)

Human (463)

Rabbit (2)

Mouse (215)

Alpaca (23)

Rat (10)

Dog (8)
Clonality

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Monoclonal (727)
Conjugate

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Unconjugated (727)