All antibodies are for Research Use Only (RUO) and not for diagnostic or therapeutic use.

Neutralizing Antibodies | Virus Blockade mAbs

Q: Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show functional activity (PRNT/pseudovirus), whereas binding antibodies may not block infection.

Q: PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT uses infectious virus (gold standard); pseudovirus enables BSL-2 functional readouts; sVNT screens receptor blocking on plates for fast throughput.

Q: How do I interpret IC50/ID50 values?

Lower IC50/ID50 denotes stronger neutralization under matched conditions; compare across the same assay setup only.

abinScience neutralizing antibodies (NAbs) block viral entry or fusion and are validated by PRNT, pseudovirus, or surrogate receptor–ligand blocking (sVNT), with IC50/ID50 titers reported where applicable. Panels span coronaviruses (e.g., RBD/ACE2 blockers), influenza (HA), RSV (F), and arboviruses (DENV/ZIKV/CHIKV). Products provide epitope/mechanism notes, variant/strain coverage, isotype and Fc options (native/engineered), and lot-specific CoAs. RUO

Why Researchers Choose abinScience

Functional Validation PRNT, pseudovirus, sVNT with IC50/ID50

Mechanism Annotated Receptor/fusion/capsid blocking

Variant Coverage Documented on datasheets

Isotype & Fc Options IgG/IgA, effector-on/off

Lot-Specific QC CoA, storage, handling guidance

Shop by Pathogen

Shop by Mechanism

Selection Guide

Assay Readout & Potency: PRNT/pseudovirus for functional titers (IC50/ID50); sVNT for rapid screening. Compare IC50 across matched assay conditions.
Epitope & Mechanism: Choose receptor-blocking (e.g., RBD–ACE2) vs. fusion blockers (e.g., RSV F); confirm neutralization across relevant variants/strains.
Isotype & Fc: IgG for general use; IgA for mucosal models; select native vs. engineered Fc (effector-on/off) to match your MoA study.
Matrix & Format: Prefer unconjugated for neutralization assays; use labeled versions for ELISA/flow tracking.
Controls: Include binding-only mAbs, isotypes, and positive NAb controls to benchmark assay performance.

Applications

Neutralization potency ranking and MoA studies

Vaccine/convalescent serum research and escape-variant assessment

Assay development: PRNT, pseudovirus, sVNT and competitive ELISAs

Documents & QC

Datasheet with assay type (PRNT/pseudovirus/sVNT), IC50 and acceptance criteria

Variant/strain coverage, epitope notes and cross-reactivity

Lot-specific CoA; storage, stability and reconstitution

FAQs

Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show activity in PRNT/pseudovirus assays, while binding antibodies recognize the antigen without necessarily blocking infection.

PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT is the classical infectious-virus gold standard; pseudovirus offers BSL-2 functional readouts; sVNT screens receptor blocking on plates. Choose per biosafety, throughput and MoA.

How do I interpret IC50/ID50 values?

Lower IC50/ID50 indicates stronger neutralization under stated conditions; compare only across matched cell lines, MOI, and incubation protocols.

RUO disclaimer

All antibodies are for Research Use Only and not for diagnostic or therapeutic use.

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shiga toxin type 2/stx2B (1)

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short-chain neurotoxin (1)

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gp120 (2)

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IFN α2/IFNA2 (1)

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NS1/gp68/gp70 (40)

CXCL4/PF4 (1)

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CCL3/MIP-1-alpha (1)

botA/BOTOX (1)

RHDV VP60 (1)

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F/Fusion glycoprotein F0 (16)

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CD227/MUC1 (1)

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ProteinUL128 & UL131A (1)

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Outer capsid protein VP4 (1)

gp120/Glycoprotein 120 (1)

RSPO3 (1)

GDF15/MIC1 (1)

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shiga toxin type 2A/stx2A (1)

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CD283/TLR3 (2)

VTCN1/B7-H4 (1)

CXCL1/NAP-3/GRO-alpha (1)

Hemagglutinin (H7 subtype) (4)

CCL2/MCP-1 (1)
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Human parvovirus B19 (HPV B19) (3)

Bovine respiratory syncytial virus (BRSV) (2)

Reston ebolavirus (REBOV) (1)

Human papillomavirus 6 (HPV6) (1)

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Dobrava-Belgrade virus (DOBV) (2)

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Human herpesvirus 1 (HSV-1/HHV-1) (3)

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Dog (10)

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Ebola virus (EBOV) (1)

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Suid alphaherpesvirus 1 (SuHV-1/PRV) (2)

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Human adenovirus 3 (HAdV-3) (1)

Sin Nombre virus (SNV) (2)

Japanese encephalitis virus (JEV) (1)

Junin mammarenavirus (JUNV) (1)

Campylobacter jejuni subsp. (1)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (22)

Influenza A virus (Flu A) (5)

Varicella-zoster virus (VZV/HHV-3) (4)

Mouse (33)

Poliovirus type 1 (PV1) (2)

Dengue virus type 2 (DENV-2) (8)

Human astrovirus-8 (HAtVs) (1)

Staphylococcus aureus (3)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)

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Epstein-Barr virus (EBV/HHV-4) (2)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)

Enterovirus 71 (EV71) (4)

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Human (177)

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Cat (1)

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Clostridium botulinum (2)

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Human endogenous retroviruses W (HERV-W) (1)

Plasmodium vivax (2)

Coxsackievirus B1 (CBV1) (3)

Zaire ebolavirus (ZEBOV) (6)

Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)

Hepatitis E virus/HEV (1)

Puumala virus (PUUV) (2)

Human hepatitis A virus (HHAV) (1)

Human respiratory syncytial virus (HRSV) (12)
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IP (9)

Nneutralization (1)

Cell Isolation (1)

Neutralization (706)

in vivo neutrophil depletion (2)

in vivo study (1)

Cell Depletion (1)

Neutralizatio (1)

in vivo neutralization (5)

in vivo research (1)

in vivo MDSC depletion (2)

ELISA (621)

in vivo protection (1)

neutralizing (1)

FCM (120)

WB (59)

in vitro neutralization (1)

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in vivo CD8+ T cell depletion (1)

in vivo CTLA-4 neutralization (2)

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ICC (3)

NK cell activation (1)

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IB (1)

IF (22)

Blocking (2)

Antagonist (1)

BLI (4)

in vivo (2)

IHC (18)
Reactivity

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Hendra virus (1)

Coxsackievirus A16 (CVA16) (3)

Bacteriophage H19B (2)

Human coronavirus HKU1 (HCoV-HKU1) (1)

Vaccinia virus (VACV) (20)

Clostridium perfringens (3)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (5)

Yellow Fever Virus (YFV) (1)

Measles virus (MeV) (2)

Pig (1)

Nipah virus (NiV) (13)

Murine norovirus 1 (MNV) (1)

O'nyong'nyong virus (ONNV) (1)

Sin Nombre Virus (1)

MERS-CoV (2)

Zika virus (1)

Epstein-Barr virus (EBV/HHV-4) (3)

Crimean-Congo hemorrhagic fever virus (2)

Nipah virus (1)

Influenza B virus (2)

Zika virus (ZIKV) (1)

Clostridioides difficile (2)

Semliki Forest virus (SFV) (1)

Chikungunya virus (1)

Porcine circovirus 2 (PCV2) (1)

Escherichia coli (1)

Clostridium tetani (1)

Monkeypox virus (MPXV) (12)

Mouse (25)

Human enterovirus 71 (EV71) (3)

Bovine viral diarrhea virus (BVDV) (2)

Venezuelan equine encephalitis virus (VEEV) (1)

Epstein-Barr virus (HHV-4) (Human herpesvirus 4) (1)

West Nile virus (WNV) (1)

Corynephage omega (3)

Norwalk virus (NV) (5)

Canine parvovirus (1)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (1)

Poliovirus type 1 (PV1) (1)

Influenza A virus (1)

Vesicular stomatitis Indiana virus (VSIV) (2)

Klebsiella pneumoniae (1)

Guertu Virus (GTV) (3)

Staphylococcus aureus (3)

Streptococcus equisimilis (1)

Scorpion (2)

Western equine encephalitis virus (WEEV) (1)

Junin mammarenavirus (JUNV) (3)

Heartland Virus (HRTV) (1)

HAstV-1 (2)

Listeria monocytogenes (1)

Hepatitis E virus/HEV (3)

Rabbit hemorrhagic disease virus (RHDV) GI.2 (1)

Theileria parva (1)

Rabies virus (RABV) (6)

Machupo virus (MACV) (1)

Parainfluenza virus 5 (PIV5) (1)

Monkeypox virus (5)

Rat (5)

Homo sapiens (Human) (1)

Eastern equine encephalitis virus (EEEV) (1)

Ophiophagus hannah (1)

RD114 retrovirus (1)

Influenza A virus (H7N1) (1)

SARS-CoV (1)

Monkey (1)

Human metapneumovirus (HMPV) (1)

Clostridium botulinum (1)

Tick-borne encephalitis virus (1)

Dengue Virus type 1 (DENV-1) (1)

Mexican scorpion (3)

HCoV-229E (2)

Human cytomegalovirus (HCMV/HHV-5) (1)

O’nyong’nyong virus (ONNV) (1)

Chikungunya virus (CHIKV) (4)

Influenza A virus (H7N3) (2)

SARS-CoV-2 (1)

Human papillomavirus 16 (HPV16) (13)

HSV-1 (3)

Hepatitis E virus (2)

severe fever with thrombocytopenia syndrome virus (SFTSV) (8)

Human astrovirus-2 (1)

Human astrovirus-8 (HAtVs) (1)

Dengue Virus type 2 (DENV-2) (1)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (8)

HCoV-OC43 (1)

Human T-cell leukemia virus 1 (HTLV-1) (2)

Human (57)

Coxsackievirus B1 (CVB1) (3)

Foot-and-mouth disease virus (FMDV) (2)

Bacillus anthracis (2)

Mayaro virus(MAYV) (1)

HSV-2 (3)

Norwalk virus (3)

Influenza A virus H7 subtype (2)

Dengue Virus type 3 (DENV-3) (1)

Naja kaouthia (1)

HCoV-NL63 (1)

Hendra virus (HeV) (12)

Hepatitis C Virus (HCV) (43)

Ross River Virus (RRV) (2)

Influenza A virus (H7N9) (1)

Japanese encephalitis virus (JEV) (2)

HIV-1 (1)

IgG1b12 (1)

Lassa virus (LASV) (16)

E. coli (1)

Puumala virus (1)

Dengue virus (1)

Human respiratory syncytial virus (HRSV) (5)

Dengue Virus type 4 (DENV-4) (1)
Host species

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Dog (8)

Rabbit (2)

Alpaca (23)

Rat (10)

Mouse (215)

Cat (1)

Human (463)
Clonality

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Monoclonal (727)
Conjugate

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Unconjugated (727)