All antibodies are for Research Use Only (RUO) and not for diagnostic or therapeutic use.

Neutralizing Antibodies | Virus Blockade mAbs

Q: Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show functional activity (PRNT/pseudovirus), whereas binding antibodies may not block infection.

Q: PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT uses infectious virus (gold standard); pseudovirus enables BSL-2 functional readouts; sVNT screens receptor blocking on plates for fast throughput.

Q: How do I interpret IC50/ID50 values?

Lower IC50/ID50 denotes stronger neutralization under matched conditions; compare across the same assay setup only.

Home > Products > Antibodies > Neutralizing Antibodies

abinScience neutralizing antibodies (NAbs) block viral entry or fusion and are validated by PRNT, pseudovirus, or surrogate receptor–ligand blocking (sVNT), with IC50/ID50 titers reported where applicable. Panels span coronaviruses (e.g., RBD/ACE2 blockers), influenza (HA), RSV (F), and arboviruses (DENV/ZIKV/CHIKV). Products provide epitope/mechanism notes, variant/strain coverage, isotype and Fc options (native/engineered), and lot-specific CoAs. RUO

Why Researchers Choose abinScience

Functional Validation PRNT, pseudovirus, sVNT with IC50/ID50

Mechanism Annotated Receptor/fusion/capsid blocking

Variant Coverage Documented on datasheets

Isotype & Fc Options IgG/IgA, effector-on/off

Lot-Specific QC CoA, storage, handling guidance

Shop by Pathogen

Shop by Mechanism

Selection Guide

Assay Readout & Potency: PRNT/pseudovirus for functional titers (IC50/ID50); sVNT for rapid screening. Compare IC50 across matched assay conditions.
Epitope & Mechanism: Choose receptor-blocking (e.g., RBD–ACE2) vs. fusion blockers (e.g., RSV F); confirm neutralization across relevant variants/strains.
Isotype & Fc: IgG for general use; IgA for mucosal models; select native vs. engineered Fc (effector-on/off) to match your MoA study.
Matrix & Format: Prefer unconjugated for neutralization assays; use labeled versions for ELISA/flow tracking.
Controls: Include binding-only mAbs, isotypes, and positive NAb controls to benchmark assay performance.

Applications

Neutralization potency ranking and MoA studies

Vaccine/convalescent serum research and escape-variant assessment

Assay development: PRNT, pseudovirus, sVNT and competitive ELISAs

Documents & QC

Datasheet with assay type (PRNT/pseudovirus/sVNT), IC50 and acceptance criteria

Variant/strain coverage, epitope notes and cross-reactivity

Lot-specific CoA; storage, stability and reconstitution

FAQs

Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show activity in PRNT/pseudovirus assays, while binding antibodies recognize the antigen without necessarily blocking infection.

PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT is the classical infectious-virus gold standard; pseudovirus offers BSL-2 functional readouts; sVNT screens receptor blocking on plates. Choose per biosafety, throughput and MoA.

How do I interpret IC50/ID50 values?

Lower IC50/ID50 indicates stronger neutralization under stated conditions; compare only across matched cell lines, MOI, and incubation protocols.

RUO disclaimer

All antibodies are for Research Use Only and not for diagnostic or therapeutic use.

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IFNA1/Interferon alpha-D (1)

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shiga toxin type 2/stx2B (1)

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MERS-CoV RBD (1)

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IGF2 (1)

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Major surface glycoprotein G (3)

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ssRNA & Genome polyprotein (2)

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shiga toxin type 1B/stx1B (2)

PSCA (1)

CD274/PD-L1 (2)

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MSLN/Mesothelin (1)

FAP/FAPalpha (1)

SOD1 (1)

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APCS/PTX2 (1)

IL5 (1)

IL20 (1)

Fusion glycoprotein (3)

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CD52 (1)

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IL2 (1)

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Pre-F/Fusion glycoprotein F0 (2)

GP1 glycoprotein (2)

Hemagglutinin (1)

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fimH (1)
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Human papillomavirus 59 (HPV59) (1)

Puumala virus (PUUV) (2)

Sudan ebolavirus (SEBOV) (1)

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Monkey (1)

Human hepatitis A virus (HHAV) (1)

Japanese encephalitis virus (JEV) (1)

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Influenza A virus (Flu A) (5)

Orthohantavirus puumalaense (PUUV) (1)

Varicella-zoster virus (VZV/HHV-3) (4)

Mouse (33)

Dobrava-Belgrade virus (DOBV) (2)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (22)

Poliovirus type 1 (PV1) (2)

Dengue virus type 2 (DENV-2) (8)

Dengue virus type 3 (DENV-3) (1)

Human papillomavirus 58 (HPV58) (3)

Human astrovirus-8 (HAtVs) (1)

Staphylococcus aureus (3)

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Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)

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Hendra virus (HeV) (2)

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Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)

Hepatitis C Virus (HCV) (9)

Suid alphaherpesvirus 1 (SuHV-1/PRV) (2)

Human papillomavirus 16 (HPV16) (2)

Rotavirus (RV) (1)

Human immunodeficiency virus 1 (HIV-1) (9)

Human (177)

Andes virus (ANDV) (2)

Chikungunya virus (CHIKV) (1)

Nipah virus (NiV) (13)

Clostridium botulinum (2)

Hepatitis E virus/HEV (1)

Zika virus (ZIKV) (4)

Coxsackievirus B1 (CBV1) (3)

Zaire ebolavirus (ZEBOV) (6)

Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)

Rat (1)

E. coli (4)

Rotavirus A (RV-A) (3)

Human adenovirus 3 (HAdV-3) (1)

Sin Nombre virus (SNV) (2)

Human endogenous retroviruses W (HERV-W) (1)

Plasmodium vivax (2)

Human respiratory syncytial virus (HRSV) (12)

Campylobacter jejuni subsp. (1)

Bovine respiratory syncytial virus (BRSV) (2)

Reston ebolavirus (REBOV) (1)

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Human parvovirus B19 (HPV B19) (3)

Clostridioides difficile (2)

Bundibugyo ebolavirus (BDBV) (1)

Human herpesvirus 1 (HSV-1/HHV-1) (3)

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Dog (10)

Enterovirus 71 (EV71) (4)

Rabbit (2)

Human metapneumovirus (2)

Machupo virus (MACV) (1)

Tai Forest ebolavirus (TAFV) (1)

Porcine circovirus 2 (PCV2) (2)

Hantaan virus (HTNV) (2)

Human cytomegalovirus (HCMV/HHV-5) (7)

Ebola virus (EBOV) (1)

Cat (1)

Streptococcus pneumoniae (1)

Brazilian scorpion (1)
Applications

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FCM (120)

WB (59)

Western blot (1)

SPR (46)

FuncS (4)

in vivo CTLA-4 neutralization (2)

NK cell activation (1)

ICC (3)

in vivo intra-tumoral regulatory T cell depletion (2)

in vivo (2)

Blocking (2)

Antagonist (1)

BLI (4)

IF (22)

IHC (18)

Nneutralization (1)

DB (3)

Cell Isolation (1)

IP (9)

in vivo neutralization (5)

in vivo study (1)

Neutralizatio (1)

Cell Depletion (1)

Neutralization (706)

in vivo neutrophil depletion (2)

RIA (1)

in vivo protection (1)

IB (1)

neutralizing (1)

in vivo research (1)

ELISA (621)

in vivo MDSC depletion (2)

in vitro neutralization (1)

in vivo CD8+ T cell depletion (1)
Reactivity

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Puumala virus (1)

Clostridium perfringens (3)

Monkeypox virus (5)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (5)

Influenza A virus (H7N1) (1)

SARS-CoV (1)

Eastern equine encephalitis virus (EEEV) (1)

Ophiophagus hannah (1)

Rabies virus (RABV) (6)

Machupo virus (MACV) (1)

Listeria monocytogenes (1)

Tick-borne encephalitis virus (1)

Bacteriophage H19B (2)

Rat (5)

RD114 retrovirus (1)

Murine norovirus 1 (MNV) (1)

Parainfluenza virus 5 (PIV5) (1)

Human metapneumovirus (HMPV) (1)

Clostridium botulinum (1)

Influenza A virus (H7N3) (2)

Dengue Virus type 1 (DENV-1) (1)

SARS-CoV-2 (1)

HSV-1 (3)

O’nyong’nyong virus (ONNV) (1)

Hepatitis E virus (2)

HCoV-229E (2)

severe fever with thrombocytopenia syndrome virus (SFTSV) (8)

Monkey (1)

Human astrovirus-2 (1)

Chikungunya virus (1)

Human cytomegalovirus (HCMV/HHV-5) (1)

Human astrovirus-8 (HAtVs) (1)

Dengue Virus type 2 (DENV-2) (1)

HSV-2 (3)

Norwalk virus (3)

Chikungunya virus (CHIKV) (4)

Human papillomavirus 16 (HPV16) (13)

HCoV-OC43 (1)

Human T-cell leukemia virus 1 (HTLV-1) (2)

Human enterovirus 71 (EV71) (3)

Influenza A virus H7 subtype (2)

Coxsackievirus B1 (CVB1) (3)

Foot-and-mouth disease virus (FMDV) (2)

Norwalk virus (NV) (5)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (8)

Human (57)

Influenza A virus (H7N9) (1)

Dengue Virus type 3 (DENV-3) (1)

Staphylococcus aureus (3)

Streptococcus equisimilis (1)

Bacillus anthracis (2)

HIV-1 (1)

Mayaro virus(MAYV) (1)

Naja kaouthia (1)

IgG1b12 (1)

Scorpion (2)

HCoV-NL63 (1)

E. coli (1)

Homo sapiens (Human) (1)

Japanese encephalitis virus (JEV) (2)

Measles virus (MeV) (2)

Human coronavirus HKU1 (HCoV-HKU1) (1)

Lassa virus (LASV) (16)

Sin Nombre Virus (1)

Dengue virus (1)

Human respiratory syncytial virus (HRSV) (5)

Dengue Virus type 4 (DENV-4) (1)

Hendra virus (HeV) (12)

Hepatitis C Virus (HCV) (43)

Ross River Virus (RRV) (2)

MERS-CoV (2)

Hendra virus (1)

Coxsackievirus A16 (CVA16) (3)

Vaccinia virus (VACV) (20)

Influenza B virus (2)

Zika virus (1)

Yellow Fever Virus (YFV) (1)

Mexican scorpion (3)

Pig (1)

Nipah virus (NiV) (13)

O'nyong'nyong virus (ONNV) (1)

Escherichia coli (1)

Crimean-Congo hemorrhagic fever virus (2)

Nipah virus (1)

Epstein-Barr virus (EBV/HHV-4) (3)

Porcine circovirus 2 (PCV2) (1)

Guertu Virus (GTV) (3)

Venezuelan equine encephalitis virus (VEEV) (1)

Clostridium tetani (1)

Canine parvovirus (1)

Epstein-Barr virus (HHV-4) (Human herpesvirus 4) (1)

Zika virus (ZIKV) (1)

Clostridioides difficile (2)

Influenza A virus (1)

Semliki Forest virus (SFV) (1)

Klebsiella pneumoniae (1)

Bovine viral diarrhea virus (BVDV) (2)

Monkeypox virus (MPXV) (12)

Mouse (25)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (1)

Heartland Virus (HRTV) (1)

Poliovirus type 1 (PV1) (1)

HAstV-1 (2)

Vesicular stomatitis Indiana virus (VSIV) (2)

Western equine encephalitis virus (WEEV) (1)

Hepatitis E virus/HEV (3)

Junin mammarenavirus (JUNV) (3)

West Nile virus (WNV) (1)

Rabbit hemorrhagic disease virus (RHDV) GI.2 (1)

Corynephage omega (3)

Theileria parva (1)
Host species

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Rabbit (2)

Mouse (215)

Human (463)

Dog (8)

Alpaca (23)

Cat (1)

Rat (10)
Clonality

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Monoclonal (727)
Conjugate

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Unconjugated (727)