All antibodies are for Research Use Only (RUO) and not for diagnostic or therapeutic use.

Neutralizing Antibodies | Virus Blockade mAbs

Q: Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show functional activity (PRNT/pseudovirus), whereas binding antibodies may not block infection.

Q: PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT uses infectious virus (gold standard); pseudovirus enables BSL-2 functional readouts; sVNT screens receptor blocking on plates for fast throughput.

Q: How do I interpret IC50/ID50 values?

Lower IC50/ID50 denotes stronger neutralization under matched conditions; compare across the same assay setup only.

abinScience neutralizing antibodies (NAbs) block viral entry or fusion and are validated by PRNT, pseudovirus, or surrogate receptor–ligand blocking (sVNT), with IC50/ID50 titers reported where applicable. Panels span coronaviruses (e.g., RBD/ACE2 blockers), influenza (HA), RSV (F), and arboviruses (DENV/ZIKV/CHIKV). Products provide epitope/mechanism notes, variant/strain coverage, isotype and Fc options (native/engineered), and lot-specific CoAs. RUO

Why Researchers Choose abinScience

Functional Validation PRNT, pseudovirus, sVNT with IC50/ID50

Mechanism Annotated Receptor/fusion/capsid blocking

Variant Coverage Documented on datasheets

Isotype & Fc Options IgG/IgA, effector-on/off

Lot-Specific QC CoA, storage, handling guidance

Shop by Pathogen

Shop by Mechanism

Selection Guide

Assay Readout & Potency: PRNT/pseudovirus for functional titers (IC50/ID50); sVNT for rapid screening. Compare IC50 across matched assay conditions.
Epitope & Mechanism: Choose receptor-blocking (e.g., RBD–ACE2) vs. fusion blockers (e.g., RSV F); confirm neutralization across relevant variants/strains.
Isotype & Fc: IgG for general use; IgA for mucosal models; select native vs. engineered Fc (effector-on/off) to match your MoA study.
Matrix & Format: Prefer unconjugated for neutralization assays; use labeled versions for ELISA/flow tracking.
Controls: Include binding-only mAbs, isotypes, and positive NAb controls to benchmark assay performance.

Applications

Neutralization potency ranking and MoA studies

Vaccine/convalescent serum research and escape-variant assessment

Assay development: PRNT, pseudovirus, sVNT and competitive ELISAs

Documents & QC

Datasheet with assay type (PRNT/pseudovirus/sVNT), IC50 and acceptance criteria

Variant/strain coverage, epitope notes and cross-reactivity

Lot-specific CoA; storage, stability and reconstitution

FAQs

Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show activity in PRNT/pseudovirus assays, while binding antibodies recognize the antigen without necessarily blocking infection.

PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT is the classical infectious-virus gold standard; pseudovirus offers BSL-2 functional readouts; sVNT screens receptor blocking on plates. Choose per biosafety, throughput and MoA.

How do I interpret IC50/ID50 values?

Lower IC50/ID50 indicates stronger neutralization under stated conditions; compare only across matched cell lines, MOI, and incubation protocols.

RUO disclaimer

All antibodies are for Research Use Only and not for diagnostic or therapeutic use.

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RBD (Omicron/JN.1) (2)

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Dupilumab (2)

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F/Fusion glycoprotein F0 (16)

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Spike (5)

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EGFRvIII-specific/EGFR variant III (2)

UL130 (1)

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ADAMTS4 (4)

Virionprotein 1/2/3 (1)

GPC3/Glypican 3 (1)

CXCL1/NAP-3/GRO-alpha (1)

SLC39A6/LIV-1 (1)

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Capsid protein VP25 (2)

LRP6 (1)

HSV- gB (1)

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Mature virion in Complex [(VP0/1/3)5]12 (2)

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CD49d/ITGA4 (1)

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Major capsid protein L1 (11)

Spike glycoprotein (1)

CD279/PD-1 (9)

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Capsid protein VP 1/2/3 (2)

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IL4 (1)

gB/UL27 (1)

CNR1/CB1 (3)

CD337/NCR3/NKp30 (1)

GP1 (2)

gp120/Glycoprotein 120 (1)

RSPO3 (1)

GDF15/MIC1 (1)

CD120b/TNFR2 (1)

shiga toxin type 2A/stx2A (1)

BAG3 (1)

ProteinUL128 & UL131A (1)

gH/Envelope glycoprotein H (1)

NLRP3 (1)

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LTA/TNF-beta (1)

Pvs25 (1)

ACE2 (3)

VSIG4/CRIg (1)

L2/Minor capsid protein L2 (2)

long-chain α-neurotoxins (1)

Outer capsid protein VP4 (1)

gp140/Env Trimer (2)
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Campylobacter jejuni subsp. (1)

Reston ebolavirus (REBOV) (1)

Human papillomavirus 6 (HPV6) (1)

Human parvovirus B19 (HPV B19) (3)

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Clostridioides difficile (2)

Bundibugyo ebolavirus (BDBV) (1)

Human cytomegalovirus (HCMV/HHV-5) (7)

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Dog (10)

Enterovirus 71 (EV71) (4)

Rabbit (2)

Human metapneumovirus (2)

Machupo virus (MACV) (1)

Brazilian scorpion (1)

Tai Forest ebolavirus (TAFV) (1)

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Cat (1)

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Human papillomavirus 59 (HPV59) (1)

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Monkey (1)

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Influenza A virus (Flu A) (5)

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Dengue virus type 1 (DENV-1) (1)

Junin mammarenavirus (JUNV) (1)

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Orthohantavirus puumalaense (PUUV) (1)

Varicella-zoster virus (VZV/HHV-3) (4)

Mouse (33)

Staphylococcus aureus (3)

Dobrava-Belgrade virus (DOBV) (2)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (22)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)

Poliovirus type 1 (PV1) (2)

Dengue virus type 3 (DENV-3) (1)

Epstein-Barr virus (EBV/HHV-4) (2)

Human papillomavirus 58 (HPV58) (3)

Human astrovirus-8 (HAtVs) (1)

Seoul virus (SEOV) (2)

Lassa virus (LASV) (1)

Dengue virus type 4 (DENV-4) (1)

Hendra virus (HeV) (2)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)

Hepatitis C Virus (HCV) (9)

Suid alphaherpesvirus 1 (SuHV-1/PRV) (2)

Human immunodeficiency virus 1 (HIV-1) (9)

Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)

Human (177)

Andes virus (ANDV) (2)

Chikungunya virus (CHIKV) (1)

Nipah virus (NiV) (13)

Plasmodium vivax (2)

Human papillomavirus 16 (HPV16) (2)

Rotavirus (RV) (1)

Coxsackievirus B1 (CBV1) (3)

Human respiratory syncytial virus (HRSV) (12)

Clostridium botulinum (2)

Hepatitis E virus/HEV (1)

Zika virus (ZIKV) (4)

Zaire ebolavirus (ZEBOV) (6)

Rat (1)

E. coli (4)

Rotavirus A (RV-A) (3)

Human adenovirus 3 (HAdV-3) (1)

Sin Nombre virus (SNV) (2)

Human endogenous retroviruses W (HERV-W) (1)
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DB (3)

Cell Isolation (1)

IP (9)

in vivo neutralization (5)

Cell Depletion (1)

Neutralization (706)

in vivo neutrophil depletion (2)

in vivo protection (1)

IB (1)

neutralizing (1)

RIA (1)

ELISA (621)

Nneutralization (1)

in vivo MDSC depletion (2)

in vitro neutralization (1)

in vivo CD8+ T cell depletion (1)

FCM (120)

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in vivo study (1)

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Western blot (1)

SPR (46)

in vivo research (1)

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in vivo CTLA-4 neutralization (2)

NK cell activation (1)

ICC (3)

in vivo intra-tumoral regulatory T cell depletion (2)

Blocking (2)

Antagonist (1)

BLI (4)

in vivo (2)

IF (20)

IHC (18)
Reactivity

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Measles virus (MeV) (2)

Lassa virus (LASV) (16)

Sin Nombre Virus (1)

Dengue virus (1)

Human respiratory syncytial virus (HRSV) (5)

Dengue Virus type 4 (DENV-4) (1)

Pig (1)

Hendra virus (HeV) (12)

Hepatitis C Virus (HCV) (43)

Ross River Virus (RRV) (2)

MERS-CoV (2)

Homo sapiens (Human) (1)

Japanese encephalitis virus (JEV) (2)

Vaccinia virus (VACV) (20)

HCoV-OC43 (1)

Human T-cell leukemia virus 1 (HTLV-1) (2)

Coxsackievirus A16 (CVA16) (3)

Clostridium tetani (1)

Zika virus (1)

Yellow Fever Virus (YFV) (1)

Mexican scorpion (3)

Clostridioides difficile (2)

Nipah virus (NiV) (13)

O'nyong'nyong virus (ONNV) (1)

Escherichia coli (1)

Porcine circovirus 2 (PCV2) (1)

Naja kaouthia (1)

HCoV-NL63 (1)

Epstein-Barr virus (EBV/HHV-4) (3)

Canine parvovirus (1)

Zika virus (ZIKV) (1)

Influenza A virus (1)

Semliki Forest virus (SFV) (1)

Klebsiella pneumoniae (1)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (1)

Guertu Virus (GTV) (3)

Bovine viral diarrhea virus (BVDV) (2)

Monkeypox virus (MPXV) (12)

Hendra virus (1)

Human coronavirus HKU1 (HCoV-HKU1) (1)

Mouse (25)

Heartland Virus (HRTV) (1)

Poliovirus type 1 (PV1) (1)

HAstV-1 (2)

Vesicular stomatitis Indiana virus (VSIV) (2)

Hepatitis E virus/HEV (3)

West Nile virus (WNV) (1)

Rabbit hemorrhagic disease virus (RHDV) GI.2 (1)

Corynephage omega (3)

Theileria parva (1)

Puumala virus (1)

RD114 retrovirus (1)

Crimean-Congo hemorrhagic fever virus (2)

Nipah virus (1)

Influenza B virus (2)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (5)

Influenza A virus (H7N1) (1)

SARS-CoV (1)

Rabies virus (RABV) (6)

Listeria monocytogenes (1)

Tick-borne encephalitis virus (1)

Bacteriophage H19B (2)

Human metapneumovirus (HMPV) (1)

Clostridium perfringens (3)

Rat (5)

Murine norovirus 1 (MNV) (1)

Parainfluenza virus 5 (PIV5) (1)

Venezuelan equine encephalitis virus (VEEV) (1)

Epstein-Barr virus (HHV-4) (Human herpesvirus 4) (1)

Influenza A virus (H7N3) (2)

Dengue Virus type 1 (DENV-1) (1)

SARS-CoV-2 (1)

HSV-1 (3)

Hepatitis E virus (2)

severe fever with thrombocytopenia syndrome virus (SFTSV) (8)

Monkey (1)

Human astrovirus-2 (1)

Clostridium botulinum (1)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (8)

Chikungunya virus (1)

Human cytomegalovirus (HCMV/HHV-5) (1)

Western equine encephalitis virus (WEEV) (1)

Coxsackievirus B1 (CVB1) (3)

Junin mammarenavirus (JUNV) (3)

Human astrovirus-8 (HAtVs) (1)

Dengue Virus type 2 (DENV-2) (1)

HSV-2 (3)

Bacillus anthracis (2)

Norwalk virus (3)

Chikungunya virus (CHIKV) (4)

Human papillomavirus 16 (HPV16) (13)

Human enterovirus 71 (EV71) (3)

Influenza A virus H7 subtype (2)

Machupo virus (MACV) (1)

Foot-and-mouth disease virus (FMDV) (2)

Norwalk virus (NV) (5)

Monkeypox virus (5)

Human (57)

Eastern equine encephalitis virus (EEEV) (1)

Ophiophagus hannah (1)

Influenza A virus (H7N9) (1)

Dengue Virus type 3 (DENV-3) (1)

Staphylococcus aureus (3)

Streptococcus equisimilis (1)

HIV-1 (1)

Mayaro virus(MAYV) (1)

IgG1b12 (1)

Scorpion (2)

E. coli (1)

HCoV-229E (2)

O’nyong’nyong virus (ONNV) (1)
Host species

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Alpaca (23)

Dog (8)

Cat (1)

Rat (10)

Mouse (215)

Rabbit (2)

Human (463)
Clonality

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Monoclonal (727)
Conjugate

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Unconjugated (727)