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Immune Checkpoint Proteins

Immune Checkpoint Proteins

Browse recombinant immune checkpoint proteins — PD-1, PD-L1, CTLA-4, LAG-3, TIGIT, TIM-3, B7-H3, and more. Produced in HEK293/CHO for native glycosylation. Available as His-tagged, Fc-chimera, and biotinylated formats for bioassay development, SPR binding, and therapeutic screening. RUO

Why Researchers Choose abinScience

≥95% Purity & Low Endotoxin Typical ≤0.1 EU/µg verified by LAL assay. Lot-specific CoA with SDS-PAGE and SEC-HPLC data included.
Verified Bioactivity Functional validation via ELISA or cell-based proliferation/signaling assay. High batch-to-batch consistency (<20% CV).
Five Expression Systems HEK293 & CHO for native PTMs; E. coli for high-yield screening; insect and yeast for balanced cost and glycosylation.
Flexible Formats Carrier-free (no BSA), His-tagged, Fc-chimera, biotinylated; lyophilized or liquid — choose the best fit for your assay.
Scalable & Reliable From µg to mg quantities with consistent lead times. Global cold-chain shipping with dry-ice packaging.

How to Select the Right Product

  1. Application: Choose carrier-free for sensitive bioassays (e.g., CAR-T expansion, organoid culture, SPR). His-tag works best for pull-down and purification workflows.
  2. Expression System: Use HEK293/CHO for native glycosylation and disulfide bonds; E. coli for cost-effective high-throughput screening; insect/yeast when moderate PTMs are sufficient.
  3. Tag & Format: His-tag for IMAC purification and binding studies; Fc-chimera for enhanced avidity and half-life; biotinylated for immobilization on streptavidin surfaces.
  4. Endotoxin: Match your assay tolerance — ≤0.1 EU/µg is recommended for immune cell culture and in vivo studies. Always verify via the lot-specific CoA.

Documents & QC Data

Download Certificate of Analysis (CoA), SDS-PAGE gels, SEC-HPLC chromatograms, and reconstitution protocols on each product page. All QC data is lot-specific and archived for traceability.

FAQs

What does “carrier-free” mean?

Carrier-free proteins contain no stabilizers (e.g., BSA), reducing interference in sensitive assays and enabling precise mass-based dosing. Ideal for SPR, BLI, and cell-based functional studies.

Which expression system should I choose?

HEK293/CHO: Native folding, glycosylation, and disulfide bonds — ideal for receptor-binding and functional studies.
E. coli: High yield and cost-effective, best for structural screening.
Insect/Yeast: Balanced PTMs with good scalability.

What endotoxin level is recommended for immune cell assays?

≤0.1 EU/µg is the standard for immune cell culture, T-cell expansion, and in vivo studies. Every lot ships with LAL-verified endotoxin data on the CoA.

How to reconstitute lyophilized proteins?

Use sterile, endotoxin-free buffer. Gently swirl — avoid vortexing. Aliquot into single-use volumes and store at -80°C to prevent freeze-thaw damage.

Are these proteins RUO or GMP-grade?

Unless explicitly labeled, all products are Research Use Only (RUO). For GMP-grade requirements, contact our team for custom manufacturing options.

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  • Product types
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    Proteins (928)
  • Expression system
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    E. coli (525)
    Insect Cells (3)
    Yeast (3)
    Mammalian Cells (397)
  • Target
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    CD62P/SELP (2)
    FUT4 (1)
    CD300g/CD300LG (1)
    CD66b/CEACAM8 (2)
    CD285/TLR5 (1)
    CD2/LFA-2/OX-34 (3)
    CD137/4-1BB (6)
    CD42c/GP1BB (1)
    CD26/DPP4 (3)
    CD354/TREM1 (3)
    CD66d/CEACAM3 (2)
    CD154/CD40L (7)
    IL1RL1/ST2 (4)
    CD264/TNFRSF10D/TRAIL-R4 (1)
    CD153/TNFSF8 (2)
    CD47/MER6 (5)
    CD253/TNFSF10/TRAIL (2)
    CD221/IGF1R (3)
    CD217/IL17RA (3)
    CD120a/TNFR1 (5)
    CD231/TSPAN7 (1)
    CD66a/CEACAM1 (2)
    CD69 (3)
    CD138/SDC1 (2)
    CD358/TNFRSF21 (1)
    CD350/FZD10 (1)
    CD283/TLR3 (3)
    CD300d/CD300LD (2)
    CD115/CSF1R (3)
    IL20RB (2)
    CD61/ITGB3 (2)
    CD140b/PDGFRB (2)
    CD200R1L (1)
    CD16b/FCGR3B (2)
    IL23R (1)
    CD56/NCAM1 (3)
    CD152/CTLA4 (4)
    CDw293/BMPR1B (1)
    CD337/NCR3/NKp30 (1)
    CD107a/LAMP1 (2)
    CD222/IGF2R (2)
    CD268/TNFRSF13C (4)
    CD5L (1)
    CD98/SLC3A2 (3)
    CD71/TFRC (6)
    CD64/FCGR1A (3)
    IL22RA1/IL22R (2)
    glycoprotein E2 (2)
    CD122/IL2RB (1)
    CD327/SIGLEC6 (2)
    CD79α/CD79A (3)
    CD21/CR2 (1)
    CD307a/FCRL1/IRTA5 (2)
    CD300b/CD300LB (1)
    CD156a/ADAM8 (2)
    CD36 (3)
    CD157/BST1 (3)
    CD134/OX40 (5)
    CD252/TNFSF4/OX40L (3)
    Cd209b (1)
    CD40/TNFRSF5 (5)
    CD23/FCER2 (4)
    CD55 (3)
    CD218b/IL18RAP (2)
    CD265/TNFRSF11A (3)
    CD328/SIGLEC7 (3)
    CD31/PECAM1 (3)
    CD109 (2)
    CD1d (5)
    CD131/CSF2RB (2)
    CD32/FCGR2A (2)
    CD158a/KIR2DL1 (1)
    CD126/IL6R (4)
    CD156c/ADAM10 (1)
    CD117/KIT (3)
    CD367/CLEC4A (3)
    IL22RA2 (1)
    CD11d/ITGAD (2)
    CD177 (2)
    CD41/ITGA2B (1)
    CD289/TLR9 (1)
    CD213a1/IL13RA1 (3)
    CD158i/KIR2DS4 (1)
    IL27RA (2)
    CD242/ICAM4 (1)
    CD220/INSR (1)
    CD273/PD-L2/PDCD1LG2 (2)
    CD49f/ITGA6 (4)
    CD4 (4)
    CD315/PTGFRN (2)
    CD74 (4)
    CD300c (2)
    CD303/CLEC4C (1)
    CD168/HMMR (1)
    CD49e/ITGA5 (2)
    CD344/FZD4 (1)
    CD85h/LILRA2 (2)
    CDw210b/IL10RB (2)
    CD34 (3)
    IL1RL2/IL-36R (1)
    CD309/VEGFR-2 (3)
    CD156b/ADAM17 (2)
    CD104/ITGB4 (3)
    CD334/FGFR4 (2)
    CD316/IGSF8 (1)
    CD191/CCR1 (2)
    CD292/BMPR1A (3)
    CD295/LEPR (2)
    CD85C/LILRB5 (3)
    CD99 (2)
    capsid protein (1)
    CD339/JAG1 (2)
    CD66c/CEACAM6 (1)
    CD274/PD-L1 (7)
    CD150/SLAMF1 (5)
    CD87/PLAUR/uPAR (1)
    CD300a (1)
    CD144/CDH5 (2)
    FLT1/VEGFR1 (1)
    CD195/CCR5 (1)
    CD171/L1CAM (5)
    CD46 (2)
    CD207 (3)
    CD247/CD3Z (2)
    CD111/NECTIN1 (1)
    CD6 (3)
    nsp3 (1)
    CD84 (4)
    CD142/F3/TF (3)
    CD279/PD-1 (8)
    CD59 (3)
    CD325/CDH2/N-cadherin (1)
    CD355/CRTAM (1)
    CD205/LY75/DEC-205 (1)
    CD271/NGFR (2)
    CD266/TNFRSF12A (3)
    CD140a/PDGFRA (3)
    CD49b & CD61 / ITGA2 & ITGB3 (1)
    CD18/ITGB2 (1)
    CD3E (3)
    CD218a/IL18R1 (3)
    CD85a/LILRB3 (2)
    CD102/ICAM2 (3)
    CD62E/SELE (4)
    CD170/SIGLEC5 (3)
    CD276/B7-H3 (4)
    CD331/FGFR1 (2)
    CD44 (2)
    CD90/THY1 (3)
    CD88/C5AR1 (1)
    CD48 (4)
    CD159a/KLRC1 (2)
    CD371/CLEC12A (1)
    CD91/LRP1 (3)
    CD135/FLT3 (4)
    CD314/KLRK1 (2)
    CD123/IL-3Rα (3)
    IL17RE (1)
    Clathrin/CLTC (1)
    CD340/ERBB2 (7)
    CD141/THBD (5)
    CD22 (4)
    CD14 (5)
    CD30/TNFRSF8 (2)
    CD101 (2)
    CD105/ENG (3)
    CD38/ADPRC 1 (3)
    CD146/MCAM (3)
    CD28 (4)
    CD278/ICOS (4)
    CD125/IL5RA (3)
    CD73/NT5E (3)
    CD212/IL12RB1 (2)
    CD160 (4)
    CD83 (3)
    CD246/ALK (1)
    CD85e/LILRA3 (2)
    CD167a/DDR1 (2)
    CD110/MPL (3)
    CD97/ADGRE5 (1)
    CD272/BTLA (1)
    CD70 (4)
    CD158b2/KIR2DL3 (2)
    CD11b/ITGAM (2)
    CD262/TRAIL-R2/DR5 (3)
    CD114/CSF3R (2)
    CD8B (2)
    CD89/FCAR (2)
    CD368/CLEC4D (1)
    CD365/KIM-1/TIM-1/HAVCR1 (1)
    IL17RC (1)
    CD288/TLR8 (1)
    CD215/IL15RA (2)
    CD178/FASLG/TNFSF6 (1)
    CD301/CLEC10A (3)
    CD66e/CEA (2)
    CD290/TLR10 (2)
    CD24 (3)
    CD3D (3)
    CD280/MRC2 (1)
    CD349/FZD9 (1)
    CD112/Nectin-2/PVRL2 (2)
    CD25/IL2RA (2)
    CD277/BTN3A1 (3)
    CD58/LFA3 (2)
    CD235b/GYPB (1)
    CD267/TNFRSF13B (2)
    CD130/IL6ST (2)
    CD129/IL9R (1)
    CD43/SPN (1)
    CD32/FcRII/Ly-17 (2)
    CD333/FGFR3 (3)
    CD352/SLAMF6 (1)
    CD197/CCR7 (2)
    CD183/CXCR3 (1)
    CD155/PVR (3)
    CD161/KLRB1 (4)
    IL1RN/IL-1ra/IL1F3 (1)
    CD258/TNFSF14/LIGHT (3)
    CD132/IL2RG (4)
    CD136/MST1R (1)
    CD208/LAMP3 (1)
    CD80/B7-1 (4)
    CD227/MUC1 (3)
    CD198/CCR8 (1)
    CD255/TNFSF12/TWEAK (2)
    CD1E (1)
    CD159c/KLRC2 (1)
    CD52 (2)
    nsp4 (1)
    CD233/SLC4A1 (2)
    CD63/LAMP3 (2)
    CD232/PLXNC1 (1)
    CD127/IL7R & TSLPR/CRLF2 Heterodimer (1)
    CD324/CDH1 (3)
    IL31RA (3)
    CDw210a/IL10RA (2)
    CD75/ST6GAL1 (2)
    CD305/LAIR1 (2)
    CD300e (2)
    CD275/ICOSLG (3)
    CD49d/ITGA4 (1)
    CD224/GGT1 (2)
    CD281/TLR1 (2)
    CD16/FcRIII (1)
    CD118/LIFR (2)
    CD230/PRNP (2)
    CD42a/GP9 (1)
    CD8a/Lyt2 (3)
    IL11RA (2)
    CD351/FCAMR (1)
    CD27 (3)
    CD42b/GP1BA (5)
    CD9 (5)
    CD49a/ITGA1/VLA-1 (2)
    CD68 (3)
    CD223/LAG3 (3)
    CD127/IL7R (3)
    CD120b/TNFR2 (3)
    CD158e/KIR3DL1 (1)
    CD124/IL4R (6)
    CD1b (2)
    CD319/SLAMF7 (4)
    CD332/FGFR2 (3)
    CD35/CR1 (1)
    CD248 (2)
    CD116/CSF2RA (3)
    CD181/CD128/CXCR1 (1)
    CD95/FAS (3)
    CD204/MSR1 (3)
    CD33 (4)
    CD284/TLR4 (2)
    CD148/PTPRJ (1)
    CD100/SEMA4D (2)
    CD235a/GYPA (3)
    CD360/IL21R (3)
    CD213a2/IL13RA2 (3)
    CD85d/LILRB2 (2)
    CD172a/SIRPA (4)
    CD353/SLAMF8 (1)
    CD243/ABCB1 (1)
    CD93/C1qR (2)
    CD151 (3)
    CD158k/KIR3DL2 (1)
    CD20/MS4A1 (4)
    CD304/NRP1 (4)
    CD29/ITGB1 (3)
    CD180 (1)
    CD37/TSPAN26 (2)
    CD369/CLEC7A (3)
    CD299/CLEC4M (2)
    CD85k/LILRB4 (2)
    CD85f/LILRA5 (2)
    CD228/MELTF (2)
    CD57/B3GAT1 (1)
    CD226/DNAM-1 (3)
    CD184/CXCR4 (2)
    CD133/PROM1 (2)
    CD82 (1)
    CD326/EPCAM (2)
    CD54/ICAM1 (3)
    CD229/LY9 (2)
    CD338/ABCG2 (1)
    CD85b/LILRA6 (1)
    CD32b/FCGR2B (2)
    CD167b/DDR2 (2)
    CD106/VCAM1 (3)
    CD1a & B2M (1)
    CD322/JAM2 (3)
    CD42d/GP5 (1)
    CD357/GITR (3)
    CD320 (1)
    CD370/CLEC9A (3)
    CD50/ICAM3 (1)
    Clathrin/CTLC (1)
    CD39/ENTPD1 (1)
    CD72 (4)
    CD119/IFNGR1 (2)
    CD169/SIGLEC1 (2)
    CD257/BAFF/BLYS (5)
    CD200 (4)
    CD249/ENPEP (1)
    CD85i/LILRA1 (1)
    CD307e/FCRL5 (2)
    Cd209a (1)
    CD335/NCR1/NKp46 (3)
    CD209 (3)
    CD298/ATP1B3 (1)
    CD179b/IGLL1 (1)
    CD200R1/OX2R (3)
    CD236/GYPC (2)
    CD286/TLR6 (1)
    CD282/TLR2 (2)
    CD165/ADAMTSL1 (1)
    CD202b/TEK/TIE-2 (3)
    CD107b/LAMP2 (1)
    CD261/TNFRSF10A (1)
    CD166/ALCAM (1)
    CD49b/ITGA2 (1)
    CD66f/PSG1 (2)
    CD256/TNFSF13/APRIL (2)
    CD366/TIM-3 (4)
    CD11c/ITGAX (2)
    CD51/ITGAV (1)
    CD318/CDCP1 (1)
    CD179a/VPREB1 (1)
    CD19 (5)
    CD201/PROCR/EPCR (3)
    CD79B (4)
    glycoprotein E1 (2)
    CD121a/IL1R1 (4)
    CD158z/KIR3DL3 (1)
    CD143/ACE (3)
    CD103/ITGAE (1)
    CD163 (5)
    CD329/SIGLEC9 (3)
    CD172b/SIRPB1 (3)
    CD81 (5)
    CD238/KEL (1)
    CD239/BCAM (4)
    CD206/MRC1 (3)
    CD62L/SELL (3)
    CD11a/ITGAL (1)
    CD296/ART1 (1)
    CD86/B7-2 (3)
    CD1c (1)
    nsp2 (1)
    CD269/BCMA (4)
    CD254/RANKL/TNFSF11 (3)
    CD300f/CD300LF (2)
    CD244 (3)
    CD182/CXCR2 (1)
    CD362/SDC2 (2)
    CD21/CR2 & CR1L (1)
    CD121b/IL1R2 (3)
    CD45/PTPRC (9)
    CD203c/ENPP3 (1)
    CD94/KLRD1 (1)
    CD270/TNFRSF14 (1)
    CD5 (2)
    CD7 (3)
    CD172g/SIRPG (2)
    CD85j/LILRB1 (2)
    CD10/MME (2)
    CD113/NECTIN3 (2)
    CD85g/LILRA4 (2)
    CD158j/KIR2DS2 (2)
    CD321/F11R/JAM-A (3)
    CD1a (1)
    CD158d/KIR2DL4 (2)
    CD99L2 (2)
    CD77/A4GALT (1)
    CD13/ANPEP/APN (2)
    CD108/SEMA7A (2)
    CD16a/FCGR3A (4)
    CD312/ADGRE2/EMR2 (1)
    CD302 (2)
    CD317/BST2 (2)
    CD147/BSG (4)
  • Species
    0 selected
    Mouse (173)
    Sindbis virus (SINV) (7)
    Red fox (1)
    Rat (3)
    Cat (2)
    Tobacco mosaic virus (1)
    Dog (22)
    Monkey (1)
    Homo sapiens (Human) (4)
    Human (709)
    Cynomolgus monkey (1)
    Pig (2)
    Mus musculus (Mouse) (2)
  • Applications
    0 selected
    SDS-PAGE (927)
    WB (927)
    ELISA (927)
    Immunogen (927)
    Bioactivity testing in progress (913)

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