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In Vivo Antibodies

abinScience in vivo antibodies are functional-grade reagents optimized for animal studies—azide-free, low endotoxin, sterile-filtered and aggregation-tested. Available in blocking, depleting, and neutralizing formats with lot-specific CoA reporting purity, endotoxin (LAL), and sterility. Includes IgG, F(ab')2, and Fc-engineered options. RUO

Why Researchers Choose abinScience

Animal-Compatible Azide-free, carrier-free, sterile buffer
Low Endotoxin LAL-tested, ≤0.1 EU/μg typical
Aggregation Control SEC-HPLC/DLS verified
Flexible Formats IgG, F(ab')2, Fc variants
Lot-Specific QC CoA with endotoxin, purity, sterility

Shop by Function

Shop by Application

Selection & Handling Guide

  1. Function: Select blocking, depleting, or neutralizing based on target and desired MoA.
  2. Format: Choose IgG for Fc-mediated effects (ADCC/CDC); F(ab')2 to eliminate FcγR binding.
  3. Dosing: Follow mg/kg guidelines from literature; common routes: i.p., i.v., s.c.
  4. QC Review: Check lot CoA for endotoxin, purity, and sterility before use.
  5. Controls: Always include matched isotype and vehicle controls.

Applications

Immunotherapy mechanism studies
Cell depletion in vivo
Cytokine blockade in disease models
Vaccine efficacy and immune modulation

Documents & QC

Lot-specific CoA: concentration, endotoxin, purity, sterility
Aggregation data (SEC-HPLC/DLS)
Recommended dosing and handling protocols

FAQs

How is an in vivo antibody different from standard lab grade?

In vivo products are azide-free, low endotoxin, sterile-filtered and aggregation-controlled, with carrier-free buffers and lot-level QC tailored to animal studies.

Should I choose IgG or F(ab')2?

Use IgG for Fc effector functions (depletion/engagement); use F(ab')2 when avoiding FcγR interactions is important.

Recommended endotoxin level?

Select low-endotoxin lots per protocol and record values from the lot-specific CoA; control endotoxin alongside dose and route.

Can these be used in humans?

No. All products are for Research Use Only (RUO) and not intended for diagnostic or therapeutic use.

What is InVivo Plus?

InVivo Plus is abinScience’s premium functional-grade specification with defined buffer, endotoxin and aggregation criteria; see the dedicated page for details.

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    Antibodies (510)
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    THPO/Thrombopoietin (1)
    APOE (1)
    CD228/MELTF (1)
    ADGRE1/F4/80 & CD3E (1)
    TNFa/TNF-alpha (2)
    CD274/PD-L1 & CD3E (1)
    IGF2 (1)
    ADAMTS4 (4)
    F2/Prothrombin/PIVKA-II (1)
    CD268/TNFRSF13C (2)
    CD314/KLRK1 & CD3E (1)
    PDGFD (1)
    CD279/PD-1 (8)
    GFRAL (1)
    IL6 (2)
    VSIR/VISTA & CD274/PD-L1 (1)
    APP/Amyloid beta (1)
    BTN3A (1)
    HTRA1/PRSS11 (1)
    TIGIT (3)
    IL1A/IL1F1 (1)
    Spike glycoprotein 2 (5)
    ROBO2 (1)
    CX3CL1/Fractalkine (1)
    LRRC15/LIB (1)
    IFNA1/Interferon alpha-D (1)
    CCL17/TARC (1)
    CD110/TPOR (2)
    CD274/PD-L1 (5)
    ProteinUL128 & UL131A (1)
    gB/UL27 (1)
    L3/CP-H/Protein II (1)
    IL23A (1)
    TPSAB1/Tryptase-1 (1)
    CD172a/SIRPA (3)
    FAP & CD3E (1)
    Glycoprotein C/Gc (2)
    IL21 (1)
    CD276/B7-H3 & CD3E (1)
    MSLN/Mesothelin (1)
    CD4 (1)
    TERM2 (1)
    IL6R (1)
    CD274/PD-L1 & CD47/MER6 (1)
    PDGFB (1)
    CSF3/G-CSF (1)
    Toxin A/tcdA (1)
    BMP6 (1)
    pro-MSTN/GDF8 (1)
    CD132/IL2RG (1)
    TGFB2/TGF-beta-2 (1)
    IFN α2/IFNA2 (1)
    HHRF3/US28 (1)
    Procapsid [(VP0/1/3) 5] 12 (2)
    NP/Nucleoprotein (3)
    CD200 & CD47/MER6 (1)
    VEGFA (1)
    Spike glycoprotein (1)
    Protein prM/prM (3)
    S2/Spike protein S2' (1)
    BMP2 (1)
    Galectin-3/Gal-3 (1)
    CXCL10/IP-10 (1)
    CD52 (1)
    CD295/LEPR (1)
    RBD (13)
    NS1 (1)
    S/Spike glycoprotein (1)
    CXCL12/SDF-1 (1)
    IL20 (1)
    HSP90 (1)
    GPA33 (1)
    VTCN1/B7-H4 (1)
    HLA-A*11:01 (1)
    Intermediate capsid protein VP6 (1)
    CCL24/Eotaxin-2/MPIF-2 (1)
    CD114/G-CSFR (1)
    Capsid protein VP25 (1)
    SSEA4 (4)
    Capsid protein VP1/VP3/VP4 (2)
    gH/gL Complexes (2)
    CD79B & CD3E (1)
    SOST (1)
    IL36RN/IL-1F5/IL-36Ra (1)
    IL31 (4)
    KLKB1/KLK3 (1)
    env/Envpolyprotein (1)
    S2 Protein (1)
    TGFB1 (2)
    TIGIT & CD274/PD-L1 (1)
    LRP6 (1)
    ACVRL1/ALK-1 & VEGFA (1)
    BMP10 (1)
    CD198/CCR8 (2)
    env/Env polyprotein (4)
    CD274/PD-L1 & CD134/OX40 (1)
    CD49d/ITGA4 (1)
    Fluorescein & CD3E (1)
    CD152/CTLA4 & CD274/PD-L1 (1)
    TRP-1 & CD47/MER6 (1)
    Flt3 ligand/FLT3LG (1)
    GP1 glycoprotein (2)
    F/Fusion glycoprotein F0 (8)
    ADAMTS5 (2)
    TRP-1 & CD3e (1)
    TGFA/TGF-alpha (1)
    CNR1/CB1 (3)
    HBEGF (1)
    iga/IgA1 protease (1)
    GDF2/BMP9 (1)
    WNT2 (2)
    mature virion in complex (5)
    gH/Envelope glycoprotein H (2)
    IL11 (2)
    NS1/Non-structural protein 1 (1)
    MUC16/CA-125 (1)
    VWF (1)
    GPC (1)
    gB/Envelope glycoprotein B (8)
    ERBB3/HER3 (1)
    CD20/MS4A1 (1)
    S1 N-terminal domain/S1-NTD (1)
    CA9 (1)
    FOLH1/PSMA (1)
    gD/Envelope glycoprotein D (2)
    F12/Coagulationfactor XII (1)
    CCL5/RANTES (1)
    RSPO3 (1)
    Fusion glycoprotein F0 (4)
    DPEP3 (1)
    CD9 (1)
    GIPR/GIP-R (2)
    Glycoprotein G (6)
    gH/UL75 (1)
    L1/Major capsid protein L1 (2)
    Capsid protein (2)
    G/Major surface glycoprotein G (2)
    IL11RA (2)
    CD137/4-1BB (2)
    CD254/RANKL/TNFSF11 (1)
    EPO (1)
    ApoC3 (1)
    ATTR/Transthyretin amyloidosis (4)
    ENT2/SLC29A2 (1)
    CCL11/Eotaxin (1)
    CD152/CTLA4 (2)
    ANGPTL3 (1)
    CD37/TSPAN26 (1)
    RBD (S6P trimer) (3)
    IL17A (4)
    Tityustoxin VII/Toxin VII/Ts7 (1)
    NS1/gp68/gp70 (6)
    CD283/TLR3 (2)
    MASP2 (1)
    APOE4 (1)
    L2/Minor capsid protein L2 (2)
    APCS/PTX2 (1)
    F9/Factor IX (1)
    gp125 (1)
    CXCL11/I-TAC (1)
    CD99 (1)
    OSM/Oncostatin-M (1)
    ADM/Adrenomedullin (1)
    P domain (1)
    CD73/NT5E (2)
    EPOR (3)
    CD40/TNFRSF5 (1)
    CXCL4/PF4 (1)
    CCL3/MIP-1-alpha (1)
    CDH11 (1)
    CTGF/CCN2 (1)
    Neuraminidase/NA (3)
    CD274/PD-L1 & CD28 (1)
    PTP4A1/PRL1 (1)
    FCGRT/FCRN (1)
    lukF (1)
    CD152/CTLA4 & CD134/OX40 (1)
    CD8a/Lyt2 (1)
    CSPG4/HMW-MAA/MCSP (1)
    PAUF (1)
    Major surface glycoprotein G (3)
    GPRC5D (1)
    TREM1 & CD46 (1)
    CD16/CD32 (1)
    shiga toxin type 2A/stx2A (1)
    EGFR/ERBB1 & CD3E (1)
    SOD1 (1)
    CCL1/I-309 (1)
    AFP/Alpha-fetoprotein (1)
    Prefusion Protein (2)
    CDH1/CDH11 (1)
    BMP4 (1)
    gp120/Glycoprotein 120 (1)
    STEAP1 (1)
    TNFSF9/4-1BBL (2)
    Capsid protein VP2 (1)
    CD16a/FCGR3A (3)
    APOE3/4 (1)
    E1 & E2 (gp35 & gp70) (3)
    S-HBsAg/SHB (1)
    C1S (1)
    RBD (Omicron/JN.1) (2)
    FedF (1)
    IL12B/IL-12 p40 (1)
    GP/Envelopment polyprotein (1)
    F8/Coagulation factor VIII (7)
    wlaB/pglK (1)
    CD20/MS4A1 & CD3E (1)
    IL8/CXCL8 (1)
    CLDN3/Claudin-3 (1)
    FGF21 (1)
    VP1/Coatprotein VP1 (2)
    CD307e/FCRL5 (1)
    PRLR (1)
    ANGPTL4 (2)
    shiga toxin type 2/stx2B (1)
    GP/Glycoprotein (5)
    CD122/IL2RB (1)
    CD340/ERBB2 (1)
    PDGFC (1)
    Major capsid protein L1 (3)
    LGR5/GPR49 (1)
    EGFRvIII & CD3E (1)
    Toxin B/tcdB (1)
    TGM2 (1)
    EGFRvIII-specific/EGFR variant III (2)
    TSLP (1)
    SAA (2)
    Protease/PR (1)
    CXCL1/NAP-3/GRO-alpha (1)
    CCL2/MCP-1 (1)
    MUC5AC (1)
    ROR1/NTRKR1 (1)
    CCL14/NCC-2 (1)
    APOE2/3/4 (1)
    IL10 (1)
    Outer capsid protein VP4 (2)
    IL18/IL1F4 (1)
    IL17F (1)
    GDF15/MIC1 (1)
    gp140/Env Trimer (2)
    CD340/ERBB2 & CD3E (2)
    CD279/PD-1 & CD274/PD-L1 (1)
    RBP2b (1)
    TREML1/TLT1 (1)
    TSG101 (2)
    ERVW-1/HERV-W-Env (1)
    SFRP1 (1)
    VLP (1)
    CD120b/TNFR2 (1)
    BAG3 (1)
    SNCA/Alpha-synuclein (5)
    Fluorescein & CD274/PD-L1 (1)
    ARG1/Arginase-1 (2)
    OPN/SPP1 (1)
    Fc Block (1)
    LAMP5 (1)
    LTA/TNF-beta (1)
    PTP4A3/PRL3 (1)
    EGFL7 (1)
    Capsid protein VP1 (2)
    HBsAg (5)
    Fusion glycoprotein/F Trimer (1)
    aPC/Activated protein C (3)
    CD3E (2)
    TSHR/LGR3 (2)
    PF45/48 (2)
    IL9 (1)
    Outer capsid glycoprotein VP7 (1)
    CD115/CSF1R (1)
    PSCA (1)
    CXCL9/MIG (1)
    ACE2 (2)
    IL13 (1)
    Blood group Hantigen/Globo H (3)
    Pre-F/Fusion glycoprotein F0 (2)
    FAP/FAPalpha (1)
    Pvs25 (1)
    Mature virion in Complex [(VP0/1/3)5]12 (2)
    CDH17/Cadherin-17 (1)
    entB/SEB (1)
    CD335/NCR1/NKp46 (1)
    Fusion glycoprotein (4)
    IL22 (1)
    gB/BALF4 (2)
    IL5 (1)
    NGF/Beta-NGF (2)
    CD279/PD-1 & CD47/MER6 (1)
    NA/Neuraminidase (1)
    IL1B/IL1F2 (1)
    Heparanase (1)
    CSF1/M-CSF (1)
    IFNAR1 (1)
    STAT3 (1)
    GDF11/BMP11 (1)
    IFNB1/IFN-beta (1)
    Envelope protein E (7)
    Alpha-toxin/hly (1)
    Fluorescein & CD47/MER6 (1)
    botA/BoNT (2)
    IL2 (1)
    HGF (1)
    TRP-1 & CD134/OX40 (1)
    CSF2/GM-CSF (1)
    CD19 & CD3E (1)
    GREM1/DAND2 (1)
    IGF1 (2)
    CFD (1)
    sLea/CA19-9 (1)
    shiga toxin type 1B/stx1B (1)
    cyaA/Cyclolysin (2)
    TCRαβ/alpha-beta TCR (1)
    CCL8/MCP-2 (1)
    VSIG4/CRIg (1)
    IL31RA (1)
    IFNG/IFN-gamma (2)
    BDNF (1)
    RAGE/AGER (3)
    gE/Envelope glycoprotein E (1)
    HA/Hemagglutinin (7)
  • Species
    0 selected
    Ebola virus (EBOV) (1)
    Human cytomegalovirus (HCMV/HHV-5) (7)
    Enterovirus 71 (EV71) (4)
    Tai Forest ebolavirus (TAFV) (1)
    Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)
    Zika virus (ZIKV) (2)
    Candida albicans (1)
    Cat (1)
    Human astrovirus-8 (HAtVs) (1)
    Enterovirus D68 (EV-D68) (2)
    Varicella-zoster virus (VZV/HHV-3) (4)
    Dog (11)
    Dengue virus type 3 (DENV-3) (1)
    Sudan ebolavirus (SEBOV) (1)
    Machupo virus (MACV) (1)
    Human respiratory syncytial virus (HRSV) (14)
    Streptococcus pneumoniae (1)
    Coxsackievirus A16 (CVA16) (2)
    Human parvovirus B19 (HPV B19) (3)
    Dengue virus type 4 (DENV-4) (1)
    Lassa virus (LASV) (1)
    Nipah virus (NiV) (13)
    Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)
    Human papillomavirus 6 (HPV6) (1)
    Porcine circovirus 2 (PCV2) (2)
    Bovine respiratory syncytial virus (BRSV) (2)
    Brazilian scorpion (1)
    Hepatitis C Virus (HCV) (9)
    Hantaan virus (HTNV) (2)
    Human papillomavirus 16 (HPV16) (2)
    Hepatitis E virus/HEV (1)
    Staphylococcus aureus (3)
    Human immunodeficiency virus 1 (HIV-1) (10)
    Human hepatitis A virus (HHAV) (1)
    Puumala virus (PUUV) (2)
    Hepatitis B virus genotype A (HBV-A) (6)
    E. coli (4)
    Orthohantavirus puumalaense (PUUV) (1)
    Japanese encephalitis virus (JEV) (1)
    Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)
    Campylobacter jejuni subsp. (1)
    Zaire ebolavirus (ZEBOV) (6)
    Human papillomavirus 58 (HPV58) (3)
    Influenza B virus (Flu B) (1)
    Dobrava-Belgrade virus (DOBV) (2)
    Rotavirus (RV) (1)
    Hendra virus (HeV) (2)
    Clostridioides difficile (2)
    Human endogenous retroviruses W (HERV-W) (1)
    Human papillomavirus 59 (HPV59) (1)
    Chikungunya virus (CHIKV) (1)
    Human (224)
    Coxsackievirus B1 (CBV1) (3)
    Poliovirus type 1 (PV1) (2)
    Rabbit (2)
    Plasmodium falciparum (2)
    Rotavirus A (RV-A) (4)
    Seoul virus (SEOV) (2)
    General (3)
    Human metapneumovirus (2)
    Plasmodium vivax (2)
    Rat (1)
    Human metapneumovirus (HMPV) (5)
    Epstein-Barr virus (EBV/HHV-4) (2)
    Junin mammarenavirus (JUNV) (1)
    Dengue virus type 2 (DENV-2) (9)
    Clostridium botulinum (2)
    Reston ebolavirus (REBOV) (1)
    Bordetella pertussis (2)
    Andes virus (ANDV) (2)
    Influenza A virus (Flu A) (9)
    Mouse (65)
    Bundibugyo ebolavirus (BDBV) (1)
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (21)
    Monkey (1)
    Human adenovirus 3 (HAdV-3) (1)
    Human herpesvirus 1 (HSV-1/HHV-1) (5)
    Sin Nombre virus (SNV) (2)
    Suid alphaherpesvirus 1 (SuHV-1/PRV) (3)
    Dengue virus type 1 (DENV-1) (1)
  • Applications
    0 selected
    T cell depletion (Reported) (1)
    DB (2)
    WB (22)
    Antagonist (1)
    IF (8)
    IP (5)
    IHC (6)
    SPR (18)
     ELISA (1)
    RIA (1)
    in vivo research (1)
    ELISA (424)
    Cell Deplete (1)
    in vivo blocking of PD-1/PD-L signaling (2)
    Neutralization (388)
    FuncS (55)
    Stimulatory (1)
    Nneutralization (1)
    in vivo PD-L1 blockade (3)
    FACS (2)
    Agonist (8)
    Blocking (41)
    Functional assay (2)
    in vivo study (4)
    in vitro PD-L1 blockade (3)
    ICC (1)
    Research in vivo (2)
    FCM (77)
    IHC-F (3)
    in vivo (1)
    T cell stimulation (Reported) (1)
    in vivo CD4+ T cell depletion (1)
  • Reactivity
    0 selected
    Human (16)
    Puumala virus (1)
    Chikungunya virus (1)
    Coxsackievirus B1 (CVB1) (3)
    Influenza B virus (1)
    Mouse (12)
  • Host species
    0 selected
    Human (319)
    Hamster (1)
    Rat (11)
    Alpaca (5)
    Mouse (161)
    Cat (1)
    Dog (8)
  • Clonality
    0 selected
    Monoclonal (510)
  • Conjugate
    0 selected
    Unconjugated (510)

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