Adenovirus (AdV) Antigens & Antibodies

Research-grade reagents for Human Adenovirus (HAdV) — a non-enveloped, double-stranded DNA virus responsible for respiratory, ocular, gastrointestinal, and urinary tract infections, with significant implications in gene therapy vector development and oncolytic virotherapy. The icosahedral capsid is composed of three major structural proteins — hexon (Protein II), penton base (Protein III), and fiber (Protein IV) — that mediate host cell attachment, entry, and serotype-specific immune recognition. We offer recombinant/polyclonal/InVivoMAb antibodies and recombinant proteins targeting structural capsid components (hexon, fiber, penton), viral protease (adenain), early gene products (E1B-55K, E1B-19K, E3/49K), and assembly factors (L1, L4), validated for ELISA, Western blot, immunohistochemistry, neutralization, and functional blocking assays. Multi-serotype coverage across HAdV-2, -3, -4, -5, -7, -19, -41, plus canine (CAdV-1) and murine (MAdV-2) adenoviruses, supports vaccine vector characterization, oncolytic virus development, seroprevalence studies, capsid engineering, and adenovirus biology research. RUO

Why Researchers Choose abinScience

Recombinant Antibodies Epitope-mapped clones targeting the HAdV-5 hexon protein (L3/CP-H/Protein II). Engineered for consistent lot-to-lot performance in ELISA-based serotype identification, capsid integrity assessment, and as reference standards for adenovirus vector quality control.

Polyclonal Antibodies Broad epitope recognition across major capsid proteins (hexon, fiber, penton), viral protease/adenain (L3), early gene products (E1B-55K, E1B-19K), immune modulator E3/49K, shutoff protein (L4), and packaging protein (L1). Multi-serotype coverage spanning HAdV-2, -3, -4, -5, -7, -19, -41, CAdV-1, and MAdV-2 for cross-reactive detection in ELISA, Western blot, IHC, and neutralization studies.

InVivoMAb Functional-Grade Low-endotoxin, azide-free anti-HAdV-3 hexon antibody for in vivo neutralization, passive immunization, and functional blocking studies in adenovirus infection models and oncolytic virus research.

Recombinant Proteins His-tagged, Strep-tagged, GST-tagged, and SUMO-tagged adenovirus antigens covering hexon, fiber, penton base, protease/adenain, E1B-55K, E1B-19K, E3/49K, shutoff protein (L4), and packaging protein (L1) from human (HAdV-2/3/4/5/7/19/41), canine (CAdV-1), and murine (MAdV-2) serotypes. Validated for SDS-PAGE and Western blot. Suitable as coating antigens for seroprevalence ELISA, immunogens for antibody generation, and reference standards for adenovirus vector potency and purity testing.

All products manufactured by AtaGenix Laboratories under ISO 9001 & ISO 13485 quality systems.

References

1. Russell WC. Adenoviruses: update on structure and function. J Gen Virol. 2009;90(Pt 1):1-20. DOI

2. San Martín C. Latest insights on adenovirus structure and assembly. Viruses. 2012;4(5):847-877. DOI

3. Reddy VS, Nemerow GR. Structures and organization of adenovirus cement proteins provide insights into the role of capsid maturation in virus entry and infection. Proc Natl Acad Sci USA. 2014;111(32):11715-11720. DOI

4. Stasiak AC, Stehle T. Human adenovirus binding to host cell receptors: a structural view. Med Microbiol Immunol. 2020;209(3):325-333. DOI