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Home > Research Area > Bacteria & Viruses-related products > Hantaan Virus (HTNV, HV)

Research-grade reagents for Hantaan Virus (HTNV) — the prototypical species of the genus Hantavirus (family Bunyaviridae, order Bunyavirales), an enveloped, negative-sense, tri-segmented RNA virus. HTNV is the causative agent of hemorrhagic fever with renal syndrome (HFRS), a severe rodent-borne zoonotic disease endemic to East Asia (particularly China, Korea, Russia) with up to 15% case fatality rate and acute kidney injury as the defining clinical feature. The viral envelope is anchored by two surface glycoproteins cleaved from a single polyprotein precursor: Gc (glycoprotein C, ~67 kDa, receptor-binding protein) and Gn (glycoprotein N, ~48 kDa, membrane fusion protein). Together, Gc and Gn form the functional entry complex and are the principal targets for neutralizing antibody responses. The nucleoprotein (N protein) is the major structural component of the helical ribonucleoprotein complex and a diagnostic marker for acute infection. We offer recombinant antibodies, InVivoMAb broad-neutralizing functional-grade antibodies, and recombinant proteins targeting Gc, Gn, and N protein, validated for ELISA, Western blot, neutralization, and immunoprecipitation. Comprehensive coverage of envelope glycoproteins and structural proteins supports serodiagnostic assay development, viral entry mechanism studies, broadly neutralizing antibody discovery, pseudovirus neutralization screening, vaccine immunogenicity testing, and HFRS pathogenesis research. RUO

Recombinant Antibodies A focused panel of sequence-defined clones targeting both major envelope glycoproteins: Gc/GP (clones 3G1, A5) which mediate initial receptor engagement and endocytic uptake, and Gn/G1 (clones AH100, SAA2516) which drive the membrane fusion process. This complementary two-protein targeting strategy enables epitope mapping across the fusion mechanism, competitive binding studies to elucidate the Gc-Gn functional interaction, and entry inhibitor screening. Suitable for pseudovirus neutralization assays and antigen-specific immune response characterization.
InVivoMAb Broad-Neutralizing Antibodies Low-endotoxin, azide-free neutralizing antibodies targeting Gc glycoprotein (clones Iv0260, Iv0261), designated as broad-neutralizing due to their potent cross-protective activity in vivo. Validated for passive immunization, viral challenge protection, and functional blocking of viral entry. These clones are particularly valuable for studying Gc-directed neutralization mechanisms and evaluating Gc-based vaccine immunogenicity across diverse HTNV strains and related hantavirus species.
Recombinant Proteins His-tagged and Fc-fused HTNV antigens covering glycoprotein N/Gn (Gn/G1 domain, available in both His and Fc formats) and nucleoprotein N (His-tagged). The Fc-fusion Gn protein enhances stability and half-life in animal studies, while His-tagged variants are optimized for ELISA coating, immunoprecipitation, and pull-down assays. The nucleoprotein is suitable as a rapid diagnostic antigen for IgM/IgG acute-phase serology development and a cross-reactive marker for hantavirus genus-level screening.

All products manufactured by AtaGenix Laboratories under ISO 9001 & ISO 13485 quality systems.

References

1. Vaheri A, Strandin T, Hepojoki J, et al. Uncovering the mystery of hantavirus infection. Nat Rev Microbiol. 2013;11(8):539-550. DOI

2. Strandin T, Hepojoki J, Vaheri A. Cytoplasmic tails of bunyavirus Gn glycoproteins—could they act as matrix protein surrogates? Virology. 2013;437(2):73-80. DOI

3. Mackow ER, Gavrilovskaya IN. Hantavirus regulation of endothelial cell barrier function. Curr Top Microbiol Immunol. 2010;338:157-173. DOI

4. Outinen TK, Laine OK, Makela SM, et al. Characterization of systemic innate immune response in hemorrhagic fever with renal syndrome patients. PLoS ONE. 2016;11(6):e0157584. DOI

14 product results for "Hantaan Virus (HTNV, HV)"

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  • InVivoMAb Anti-PUUV Glycoprotein Gc Antibody (4G2)
    InVivoMAb Anti-PUUV Glycoprotein Gc Antibody (4G2)
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    Species reactivity

    Orthohantavirus puumalaense (Puumala virus) (PUUV), Andes virus (Andes orthohantavirus)

    Applications

    ELISA, Neutralization

    Host species

    Human

    Isotype

    IgG1

    Clone ID

    4G2

    Price(USD): $370.00-$1,484.00
    Cat No. VK646010
  • Anti-HTNV Glycoprotein Gc Recombinant Antibody (3G1)
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    Species reactivity

    Korean hemorrhagic fever virus (KHFV) (Hantaan virus) (HTNV)

    Applications

    ELISA, FCM, IF, WB

    Host species

    Human

    Isotype

    IgG1

    Clone ID

    3G1

    Price(USD): $191.00-$1,858.00
    Cat No. VK646013
  • Anti-HTNV Glycoprotein Gc Recombinant Antibody (A5)
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    Species reactivity

    Korean hemorrhagic fever virus (KHFV) (Hantaan virus) (HTNV)

    Applications

    ELISA

    Host species

    Human

    Isotype

    IgG1

    Clone ID

    A5

    Price(USD): $126.00-$1,858.00
    Cat No. VK646023
  • InVivoMAb Anti-Hantavirus Glycoprotein Gc Broad-Neutralizing Antibody (Iv0260)
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    Species reactivity

    Korean hemorrhagic fever virus (KHFV) (Hantaan virus) (HTNV), Orthohantavirus puumalaense (Puumala virus) (PUUV), Dobrava-Belgrade virus (DOBV), Seoul virus (SEOV), Andes virus (Andes orthohantavirus), Sin Nombre virus (SNV)

    Applications

    ELISA, Neutralization

    Host species

    Human

    Isotype

    IgG1

    Clone ID

    Iv0260

    Price(USD): $370.00-$1,484.00
    Cat No. VK646020
  • InVivoMAb Anti-Hantavirus Glycoprotein Gc Broad-Neutralizing Antibody (Iv0261)
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    Species reactivity

    Korean hemorrhagic fever virus (KHFV) (Hantaan virus) (HTNV), Orthohantavirus puumalaense (Puumala virus) (PUUV), Dobrava-Belgrade virus (DOBV), Seoul virus (SEOV), Andes virus (Andes orthohantavirus), Sin Nombre virus (SNV)

    Applications

    ELISA, Neutralization

    Host species

    Human

    Isotype

    IgG1

    Clone ID

    Iv0261

    Price(USD): $370.00-$1,484.00
    Cat No. VK646030
  • Anti-Hantavirus Glycoprotein GP Broadly Neutralizing Reference Antibody (ADI-42898, RUO)
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    Species reactivity

    Orthohantavirus puumalaense (Puumala virus) (PUUV), Korean hemorrhagic fever virus (KHFV) (Hantaan virus) (HTNV), Seoul virus (SEOV), Dobrava-Belgrade orthohantavirus (Dobrava virus) (DOBV), Andes virus (Andes orthohantavirus), Sin Nombre orthohantavirus (SNV)

    Applications

    ELISA, Bioactivity: FACS, Functional assay, Research in vivo

    Host species

    Human

    Isotype

    IgG1

    Clone ID

    ADI-42898

    Price(USD): $370.00-$1,484.00
    Cat No. VK646016
  • Anti-Hantavirus Glycoprotein GP Broadly Neutralizing Reference Antibody (ADI-65533, RUO)
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    Species reactivity

    Orthohantavirus puumalaense (Puumala virus) (PUUV), Korean hemorrhagic fever virus (KHFV) (Hantaan virus) (HTNV), Seoul virus (SEOV), Dobrava-Belgrade orthohantavirus (Dobrava virus) (DOBV), Andes virus (Andes orthohantavirus), Sin Nombre orthohantavirus (SNV)

    Applications

    ELISA, Bioactivity: FACS, Functional assay, Research in vivo

    Host species

    Human

    Isotype

    IgG1

    Clone ID

    ADI-65533

    Price(USD): $370.00-$1,484.00
    Cat No. VK646026
  • Anti-Hantavirus Glycoprotein GP Broadly Neutralizing Reference Antibody (ADI-65534, RUO)
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    Species reactivity

    Orthohantavirus puumalaense (Puumala virus) (PUUV), Korean hemorrhagic fever virus (KHFV) (Hantaan virus) (HTNV), Seoul virus (SEOV), Dobrava-Belgrade orthohantavirus (Dobrava virus) (DOBV), Andes virus (Andes orthohantavirus), Sin Nombre orthohantavirus (SNV)

    Applications

    ELISA, Bioactivity: FACS, Functional assay, Research in vivo

    Host species

    Human

    Isotype

    IgG1

    Clone ID

    ADI-65534

    Price(USD): $370.00-$1,484.00
    Cat No. VK646036
  • BCCV N/Nucleoprotein Recombinant Protein (N-His)
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    Expression system

    E. coli

    Accession

    I7GVL4

    Protein length

    Met1-Ile428

    Applications

    ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

    Species

    Black Creek Canal orthohantavirus (BCCV)

    Price(USD): $211.00-$1,627.00
    Cat No. VK484012
  • BCCV Glycoprotein Gc Recombinant Protein (N-His)
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    Expression system

    E. coli

    Accession

    P0DTJ0

    Protein length

    Asp655-Asn1110

    Applications

    ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

    Species

    Black Creek Canal orthohantavirus (BCCV)

    Price(USD): $211.00-$1,627.00
    Cat No. VK646012