Research-grade reagents for Hantaan Virus (HTNV) — the prototypical species of the genus Hantavirus (family Bunyaviridae, order Bunyavirales), an enveloped, negative-sense, tri-segmented RNA virus. HTNV is the causative agent of hemorrhagic fever with renal syndrome (HFRS), a severe rodent-borne zoonotic disease endemic to East Asia (particularly China, Korea, Russia) with up to 15% case fatality rate and acute kidney injury as the defining clinical feature. The viral envelope is anchored by two surface glycoproteins cleaved from a single polyprotein precursor: Gc (glycoprotein C, ~67 kDa, receptor-binding protein) and Gn (glycoprotein N, ~48 kDa, membrane fusion protein). Together, Gc and Gn form the functional entry complex and are the principal targets for neutralizing antibody responses. The nucleoprotein (N protein) is the major structural component of the helical ribonucleoprotein complex and a diagnostic marker for acute infection. We offer recombinant antibodies, InVivoMAb broad-neutralizing functional-grade antibodies, and recombinant proteins targeting Gc, Gn, and N protein, validated for ELISA, Western blot, neutralization, and immunoprecipitation. Comprehensive coverage of envelope glycoproteins and structural proteins supports serodiagnostic assay development, viral entry mechanism studies, broadly neutralizing antibody discovery, pseudovirus neutralization screening, vaccine immunogenicity testing, and HFRS pathogenesis research. RUO
All products manufactured by AtaGenix Laboratories under ISO 9001 & ISO 13485 quality systems.
1. Vaheri A, Strandin T, Hepojoki J, et al. Uncovering the mystery of hantavirus infection. Nat Rev Microbiol. 2013;11(8):539-550. DOI
2. Strandin T, Hepojoki J, Vaheri A. Cytoplasmic tails of bunyavirus Gn glycoproteins—could they act as matrix protein surrogates? Virology. 2013;437(2):73-80. DOI
3. Mackow ER, Gavrilovskaya IN. Hantavirus regulation of endothelial cell barrier function. Curr Top Microbiol Immunol. 2010;338:157-173. DOI
4. Outinen TK, Laine OK, Makela SM, et al. Characterization of systemic innate immune response in hemorrhagic fever with renal syndrome patients. PLoS ONE. 2016;11(6):e0157584. DOI
Puumala virus
ELISA, Neutralization
Human
IgG1
4G2
Hantaan virus (HTNV), Puumala virus (PUUV), Dobrava-Belgrade virus (DOBV), Seoul virus (SEOV), Andes virus (ANDV), Sin Nombre virus (SNV)
ELISA, Neutralization
Human
IgG1
Iv0260
Hantaan virus (HTNV), Puumala virus (PUUV), Dobrava-Belgrade virus (DOBV), Seoul virus (SEOV), Andes virus (ANDV), Sin Nombre virus (SNV)
ELISA, Neutralization
Human
IgG1
Iv0261
Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus)
ELISA, FCM, IF, WB
Human
IgG1
3G1
Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus)
ELISA
Human
IgG1
A5
Puumala virus
ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Human
IgG1
ADI-42898
Puumala virus
ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Human
IgG1
ADI-65533
Puumala virus
ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Human
IgG1
ADI-65534
E. coli
I7GVL4
Met1-Ile428
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Black Creek Canal orthohantavirus (BCCV)
E. coli
P0DTJ0
Asp655-Asn1110
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Black Creek Canal orthohantavirus (BCCV)