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Home > Featured Products > Oncology Research > Colorectal Cancer

Colorectal Cancer Research Reagents

Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. Molecular characterization — RAS/RAF status, microsatellite instability (MSI), and immune checkpoint expression — is essential for treatment selection. abinScience provides reagents targeting KRAS, BRAF, MMR proteins (MLH1/MSH2/MSH6/PMS2), CEA, EGFR, and PD-1/PD-L1 for CRC research and biomarker validation. RUO

Key Biomarkers & Targets

KRAS / BRAF
RAS-MAPK Pathway
KRAS mutations in ~45% of CRC; BRAF V600E in ~10%. Critical for anti-EGFR eligibility. 160+ combined antibodies and proteins.
Antibodies • Proteins
MSI / MMR Panel
MLH1, MSH2, MSH6, PMS2
MSI-H/dMMR status predicts checkpoint inhibitor response. Antibodies available for all four MMR proteins.
Antibodies
CEA
CEACAM5 / CD66e
Gold-standard serum biomarker for CRC recurrence monitoring. Also emerging bispecific and ADC target. 100+ products.
Antibodies • Biosimilars
EGFR
ErbB1 / HER1
Cetuximab/panitumumab target in RAS wild-type CRC. 180+ antibodies and biosimilar-grade reference proteins.
Antibodies • Proteins • Biosimilars
PD-1 / PD-L1
CD279 / CD274
Pembrolizumab first-line for MSI-H/dMMR CRC. 260+ combined checkpoint antibodies, proteins, and biosimilars.
Antibodies • Proteins • Biosimilars
VEGF / HER2
Angiogenesis & Amplification
Bevacizumab backbone in CRC regimens; HER2 amplification in ~3% guides trastuzumab + pertuzumab. 300+ combined products.
Antibodies • Proteins • Biosimilars

Why Researchers Choose abinScience for CRC

Complete RAS/RAF ProfilingKRAS, NRAS, and BRAF antibodies for WB and IHC to characterize MAPK pathway activation and anti-EGFR resistance in CRC.
MSI/MMR IHC PanelMLH1, MSH2, MSH6, PMS2 antibodies available. See product pages for validated applications.
CEA Monitoring ToolsAnti-CEA antibodies with ELISA and IHC validation, plus research-grade CEA biosimilar proteins.
Protein–Antibody–Kit WorkflowSame target as recombinant protein, detection antibody, and ELISA kit from one manufacturer for streamlined assay development.
Original Manufacturer PricingDirect-from-manufacturer pricing with no distributor markup. Bulk and custom conjugation options available.

Common Research Applications

  1. RAS/RAF mutation profiling: Validate KRAS/NRAS/BRAF mutation status using our antibodies (WB, IHC) alongside recombinant mutant proteins as assay controls for anti-EGFR therapy eligibility assessment.
  2. MSI/dMMR screening: Apply our four-marker MMR IHC panel (MLH1, MSH2, MSH6, PMS2) on FFPE CRC tissue to identify patients eligible for immune checkpoint inhibitor therapy.
  3. Post-surgical surveillance: Use CEA antibodies and ELISA kits for serial monitoring of circulating CEA levels in CRC patients after curative resection.
  4. Immunotherapy biomarker discovery: Profile PD-L1 expression and tumor-infiltrating lymphocytes using our checkpoint antibody panel to stratify CRC patients for immunotherapy trials.

Documents & QC Data

Download product datasheets, validation images (WB/IHC/IF/FC), CoA, and application protocols on each product page. All data is lot-specific.

FAQs

Do you offer a complete MMR/MSI IHC panel?

Yes. We offer antibodies for all four MMR proteins — MLH1, MSH2, MSH6, and PMS2 — for IHC assessment of mismatch repair deficiency in CRC FFPE tissue. These are research use only.

Which KRAS antibodies do you carry?

We offer both polyclonal anti-KRAS antibodies that detect wild-type and common mutant forms, as well as recombinant KRAS proteins (wild-type and G12C/G12D/G12V) as assay controls.

Can your CEA reagents be used for ELISA development?

Yes. Multiple anti-CEA/CEACAM5 clones available: 1A088, 1A089 (ELISA, IHC, WB), SAA1208 (ELISA, FC, IF, WB), BW250/183 (FC; FITC/APC/PE/PerCP conjugates). Recombinant CEA proteins also available.

Do you have reagents for HER2-positive CRC?

Yes — HER2 amplification in CRC (~3%) is targetable with trastuzumab + pertuzumab. We offer anti-HER2 antibodies (IHC, WB) and biosimilar-grade reference proteins for comparability studies.

Can I get custom antibodies for novel targets?

Yes — our parent company AtaGenix provides full custom antibody development from immunogen design through hybridoma production and characterization, including targets not yet in our catalog.

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    IgG1 (7)
    IgG1-lambda (2)
    IgG2-kappa (1)
    IgG2-lambda (1)
    IgG2 (2)
    IgG3 (1)
    IgG3-lambda (2)
    lgM (1)
    IgM-kappa (4)
    lgM-Lambda (1)
    IL27 (1)
    Cd209b (1)
    CD294/PTGDR2 (1)
    CD307e/FCRL5 (1)
    CD350/FZD10 (1)
    CD367/CLEC4A (1)
    CD368/CLEC4D (1)
    CD369/CLEC7A (1)
    CD370/CLEC9A (2)
    CD371/CLEC12A (1)
    CD89/FCAR (1)
    PDGFD (1)
    DLL3 (3)
    LOXL2 (1)
    Reticulon-4/RTN4 (2)
    VSIR/VISTA (1)
    STAB1/Stabilin-1 (1)
    CD175s/STn (1)
    TCRαβ/alpha-beta TCR (3)
    Lymphoma (1)
    Lewis Y/Le(y) (1)
    SIGLEC15/CD33L3 (2)
    TRBC1 (1)
    CLEC5A/MDL1 (1)
    SIGLEC8/SAF-2 (1)
    CD112R/PVRIG (1)
    TCRγ/δ (1)
    TCRVβ 4 (1)
    TCRVβ 8 (1)
    TCRVβ 8.1/8.2 (1)
    TCRVγ 2 (1)
    TCRVγ 3 (1)
    TCRα (1)
    TCRβ (1)
    TRGV9/Vγ 9 (1)
    CLEC2D/OCIL/LLT1 (1)
    TRDV1/TCR VD 1 (1)
    IgG4 (S228P) (1)
    IgG4-lambda (2)
    Ly6g/Ly-6G.1 (1)
    CD8 (4)
    CD16/CD32 (1)
    TIMD4/TIM-4 (1)
    TNFRSF25 (1)
    TCRVα (1)
    VSIG4/CRIg (2)
    KLRG1/CLEC15A (1)
    GPR20 (1)
    SLC5A8 (1)
    TMIGD2/CD28H/IGPR1 (1)
    H2-L (1)
    HHLA2 (2)
    VHH (2)
    VHH-mFc (1)
    VHH-hFc (IgG1) (1)
    CDH19/Cadherin-19 (1)
    sLea/CA19-9 (2)
    ENTPD2/CD39L1 (2)
    P2RX4 (1)
    TMEFF1 (1)
    HS6ST2 (2)
    Ly76/TER119 (1)
    GPC2/Glypican-2 (2)
    LAMP5 (1)
    CADM3/NECL-1/TSLL1 (1)
    HLA-A/B/C Monomorphic (1)
    HLA-B*27 (1)
    HLA-DRA (1)
    HLA-DRB1 (3)
    HLA-DR10 (1)
    HLA-DP Monomorphic (1)
    HLA-DQ Monomorphic (1)
    HLA-DR Monomorphic (1)
    H2-Ab1/MHCII (2)
    ROBO4 (1)
    MUC4 (1)
    glyco-MUC4 (1)
    CD175/Tn (1)
    Complement C5b-9 Complex (1)
    BTN2A1 (1)
    BTN2A1/BTN2A2 (1)
    S1PR3 (1)
    STEAP2 (1)
    Glycosaminoglycans (GAGs) (2)
    Protein A/SPA (1)
    pstS1 (2)
    acp-1 (2)
    DPEP3 (1)
    CD77 (3)
    IgE (2)
    TF/CD176 (3)
    FOXP3 (4)
    KRAS/K-Ras 2 (6)
    APOH (4)
    BRAF/B-Raf (4)
    MLH1 (2)
    TP53BP1 (2)
    SMAD4 (2)
    MAPRE1 (1)
    RRM2B (1)
    APPL1 (1)
    CD201/PROCR/EPCR (2)
    TP53TG5 (1)
    NRAS (2)
    WRAP53 (1)
    TRIAP1 (1)
    ERBIN (2)
    TIGAR (1)
    p-TP53 (1)
    KCNIP1/KChIP1 K+ channel (3)
    EGFRvIII-specific/EGFR variant III (2)
    EGFRvIII & CD3E (1)
    ACVRL1/ALK-1 & VEGFA (1)
    PC/aPC (1)
    EGFR & CD3E (1)
    APC (1)
    CDX2 (1)
    PIK3CA (2)
    KRAS/K-Ras 2 (G12D) (1)
    KRAS/K-Ras 2 (G12C) (1)
    VEGF/ANG-2 (1)
    PD-L1 & VEGF (1)
    4-1BB & FAP (1)
    B7-H3 & EGFR (1)
    CD28 & EGFR (1)
    4-1BB & HER2 (1)
    vegfab (2)
    EGFR (2)
    CD340/ERBB2/HER2 (6)
    ERBB2 / HER2 / CD340 & CD137/4-1BB/TNFRSF9 (1)
    CD340/ERBB2/HER2&CD314/KLRK1/NKG2D (1)
    VEGFA & B7-H1 / PD-L1 / CD274 (1)
    CD66e/CEA/CEACAM5 (1)
    PDL1 (1)
    PMS2 (1)
    AMER1 (1)
    MAPRE2 (1)
    CLEC14A (1)
    PDL1 & VEGF (1)
    PD1 / VEGF-A (2)
    PD-L1 / VEGF-A (1)
    EGFRvIII (1)
    scFv (4)
    HLA-A2-peptide (SLLMWITQV) Complex (1)
    EGFR/ERBB1/HER1 & CD3E & Albumin/HSA (1)
    CD314/KLRK1/NKG2D & EGFR/ERBB1/HER1 (1)
    CD340/ERBB2/HER2 & CD3E (1)
    EGFR/ERBB1/HER1 & CD3E (1)
    CXCL17/DMC/VCC1 (1)
    SLITRK5 (1)
    CD261/TNFRSF10A/DR4 (1)
    KRAS (2)
    HER2 (domain III) (1)
    CDH1/CDH11 (1)
    TP53 (1)
  • Species
    0 selected
    Human (223)
    Mouse (8)
    Dog (7)
    Rabbit (2)
    Rat (2)
    Zebrafish (1)
    Mus musculus (Mouse) (2)
    Homo sapiens (Human) (5)
    Canis lupus familiaris (Dog) (2)
  • Applications
    0 selected
    ELISA (773)
    IHC (62)
    WB (236)
    FCM (1119)
    IF (65)
    Bioactivity: FACS (172)
    Functional assay (179)
    Research in vivo (179)
    SPR (1)
    Isotype Control (52)
    IF (P) (2)
    IF-Fr (1)
    IF(P) (1)
    DB (1)
    ICC-Fr (1)
    Control (1)
    ICC (1)
    Blocking (1)
    GICA (2)
    IFA (2)
    TIA (2)
    IP (4)
    RIA (1)
    FuncS (9)
    Neutralization (5)
    SDS-PAGE (54)
    Immunogen (54)
    Bioactivity testing in progress (44)
    FACS (11)
    Functional assay (11)
    Research in vivo (3)
    In vivo Control (1)
  • Reactivity
    0 selected
    Human (1014)
    Mouse (181)
    Rat (35)
    General (6)
    Monkey (9)
    Bovine (5)
    Hamster (2)
    Dog (9)
    Pig (6)
    Rabbit (1)
    Human astrovirus-8 (HAtVs) (1)
    Chicken (6)
    Baboon (1)
    Horse (1)
    Staphylococcus aureus (1)
    Mycobacterium tuberculosis (4)
    Cat (3)
    Artemia salina (1)
    Carassius auratus (2)
    Cavia porcellus (2)
    Cyprinus carpio (2)
    Danio rerio (3)
    Drosophila ananassae (1)
    Drosophila erecta (1)
    Drosophila grimshawi (2)
    Drosophila mauritiana (1)
    Drosophila melanogaster (1)
    Drosophila sechellia (1)
    Drosophila simulans (1)
    Drosophila virilis (1)
    Drosophila willistoni (2)
    Drosophila yakuba (1)
    Harvey murine sarcoma virus (1)
    Kirsten murine sarcoma virus (2)
    Kryptolebias marmoratus (2)
    Limanda limanda (2)
    Meleagris gallopavo (1)
    Mesocricetus auratus (2)
    Moloney murine sarcoma virus (1)
    Monodelphis domestica (2)
    Murine sarcoma virus NS.C58 (1)
    Oryzias latipes (2)
    Pongo abelii (4)
    Rasheed rat sarcoma virus (1)
    Xenopus laevis (2)
    Pan troglodytes (1)
    Chlorocebus aethiops (1)
    Equus asinus (1)
    Macaca fascicularis (2)
    Macaca fuscata fuscata (1)
    Macaca mulatta (1)
    Marmota monax (1)
    Oryctolagus cuniculus (1)
    Tupaia belangeri (1)
    Avian retrovirus IC10 (1)
    Avian rous-associated virus type 1 (1)
    Coturnix japonica (2)
    Ovis aries (1)
    Bos taurus (2)
    Coturnix coturnix (1)
    Frog (1)
    Homo sapiens (2)
    Homo sapiens (Human) (5)
  • Host species
    0 selected
    Rabbit (69)
    Mouse (741)
    Human (427)
    Humanized (37)
    Chimeric (9)
    Rat (87)
    Goat (1)
    Monkey (1)
    Chicken (1)
    Llama (1)
    Hamster (2)
    Armenian Hamster (3)
    Dog (6)
    Feline (4)
    Canine (3)
    Alpaca (8)
    Guinea pig (1)
    HEK293T (1)
  • Clonality
    0 selected
    Polyclonal (55)
    Monoclonal (1356)
  • Conjugate
    0 selected
    APC (1061)
    Unconjugated (268)
    FITC (16)
    PerCP (16)
    PE (16)

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