MHC Complexes & Tetramers | Peptide-MHC Reagents

Detect and characterize antigen-specific T cells with our peptide-MHC (pMHC) complexes and MHC-β2-microglobulin (B2M) monomers. These reagents present defined peptide epitopes in the context of MHC class I molecules — enabling T cell receptor (TCR) binding studies, antigen-specific CD8+ T cell enumeration, neoantigen validation, and immunotherapy immune monitoring. Available alleles include HLA-A*02:01, HLA-A*01:01, HLA-A*24:02, HLA-B*07:02 (human) and H-2Kb, H-2Db (mouse). All products are designated Research Use Only (RUO) — not intended for diagnostic or therapeutic procedures. RUO

Why Researchers Choose abinScience

Peptide-MHC Monomers Refolded MHC class I heavy chain + B2M + peptide monomers. Use as building blocks for tetramer assembly (with streptavidin-fluorophore), or directly in SPR/BLI TCR binding affinity studies.

Pre-Loaded Peptide Epitopes Available with clinically relevant peptide epitopes: viral (CMV pp65, EBV, SARS-CoV-2), tumor-associated (NY-ESO-1, MART-1, WT1), and model (OVA SIINFEKL). Custom peptide loading available on request via AtaGenix CRO services.

Neoantigen & Immunotherapy Research Validate predicted neoantigens by testing pMHC binding to patient-derived T cells. Support CAR-T, TCR-T, and checkpoint immunotherapy immune monitoring by quantifying tumor-reactive CD8+ T cell frequencies.

Multiple Allele Coverage Human HLA alleles covering >80% of global populations: HLA-A*02:01 (Caucasian, Asian), HLA-A*24:02 (Asian), HLA-A*01:01, HLA-B*07:02. Mouse alleles: H-2Kb, H-2Db for preclinical models.

Quality Controlled Each lot validated for proper refolding (SEC-HPLC), peptide occupancy (LC-MS/MS), and T cell staining (FC with peptide-specific T cell lines). Supplied lyophilized with reconstitution protocol.