Anti-Human NLRX1 Polyclonal Antibody (HP387014)

Name: Anti-Human NLRX1 Polyclonal Antibody
Brand: abinScience
SKU: HP387014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HP387014

Description

Anti-Human NLRX1 Polyclonal Antibody (HP387014) is a rabbit polyclonal antibody detecting NLRX1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human NLRX1 (Arg667-Ser975).

Target

NLR family member X1, NOD5, Caterpiller protein 11.3, NOD9, Nucleotide-binding oligomerization domain protein 9, NLRX1, Nucleotide-binding oligomerization domain protein 26, Nucleotide-binding oligomerization domain protein 5, NOD26, CLR11.3

Purification

Purified by antigen affinity column.

Accession

Q86UT6

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

NLR family member X1 (NLRX1) is a ~107 kDa protein. Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species.

1. Moore, CB. et al. (2008) Nature 451, 573-7. PMID: 18200010

2. Lei, Y. et al. (2012) Immunity 36, 933-46. PMID: 22749352

3. Li, H. et al. (2016) Molecular immunology 76, 90-7. PMID: 27393910

4. Tattoli, I. et al. (2008) EMBO reports 9, 293-300. PMID: 18219313

Note

For research use only.

Images

References

Datasheet

Anti-Human NLRX1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human NLRX1 Polyclonal Antibody (HP387014)

Overview

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References

Datasheet

SDS

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