Anti-Human TAX1BP1 Polyclonal Antibody (HP605014)

Name: Anti-Human TAX1BP1 Polyclonal Antibody
Brand: abinScience
SKU: HP605014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HP605014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human TAX1BP1 (His16-Lys146).

Target

Tax1-binding protein 1, TAX1BP1, TRAF6-binding protein, T6BP

Purification

Purified by antigen affinity column.

Accession

Q86VP1

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Tax1-binding protein 1 (TAX1BP1) is a ~90 kDa protein. Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation. Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates. Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production. Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways. Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling.

1. Hu, S. et al. (2018) Journal of molecular biology 430, 3283-3296. PMID: 29940186

2. Fu, T. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E11651-E11660. PMID: 30459273

3. Baillet, N. et al. (2019) Viruses 11. PMID: 30909570

4. Shembade, N. et al. (2007) The EMBO journal 26, 3910-22. PMID: 17703191

5. Gao, L. et al. (2011) The Journal of biological chemistry 286, 36592-602. PMID: 21885437

6. Choi, YB. et al. (2017) Molecular and cellular biology 37. PMID: 27736772

7. Tumbarello, DA. et al. (2015) PLoS pathogens 11, e1005174. PMID: 26451915

8. Ohnstad, AE. et al. (2020) The EMBO journal 39, e104948. PMID: 33226137

9. Turco, E. et al. (2021) Nature communications 12, 5212. PMID: 34471133

10. Yang, Q. et al. (2017) PLoS pathogens 13, e1006600. PMID: 28898289

Note

For research use only.

Images

References

Datasheet

Anti-Human TAX1BP1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Human TAX1BP1 Polyclonal Antibody (HP605014)

Overview

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