Anti-Human KAT8 Polyclonal Antibody (HP281014)

Name: Anti-Human KAT8 Polyclonal Antibody
Brand: abinScience
SKU: HP281014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HP281014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human KAT8 (Glu158-Lys432).

Target

MYST-1, hMOF, Histone acetyltransferase KAT8, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1, KAT8, MYST1, MOF, Lysine acetyltransferase 8

Purification

Purified by antigen affinity column.

Accession

Q9H7Z6

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Histone acetyltransferase KAT8 is a ~52 kDa protein. Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) or 'Lys-16' (H4K16ac), depending on the context. Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction. H4K16ac constitutes the only acetylation mark intergenerationally transmitted and regulates key biological processes, such as oogenesis, embryonic stem cell pluripotency, hematopoiesis or glucose metabolism. The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac. The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome.

1. Pardo, PS. et al. (2002) The Journal of biological chemistry 277, 50860-6. PMID: 12397079

2. Smith, ER. et al. (2005) Molecular and cellular biology 25, 9175-88. PMID: 16227571

3. Mendjan, S. et al. (2006) Molecular cell 21, 811-23. PMID: 16543150

4. Cai, Y. et al. (2010) The Journal of biological chemistry 285, 4268-72. PMID: 20018852

5. Kadlec, J. et al. (2011) Nature structural & molecular biology 18, 142-9. PMID: 21217699

6. Yuan, H. et al. (2012) The EMBO journal 31, 58-70. PMID: 22020126

7. Huang, J. et al. (2012) Cell research 22, 1078-81. PMID: 22547026

8. Li, L. et al. (2020) The Journal of clinical investigation 130, 1431-1445. PMID: 31794431

9. Monserrat, J. et al. (2021) Nature cell biology 23, 401-412. PMID: 33837287

Note

For research use only.

Images

References

Datasheet

Anti-Human KAT8 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Human KAT8 Polyclonal Antibody (HP281014)

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