Anti-Human ABCC2 Polyclonal Antibody (HV352014)

Name: Anti-Human ABCC2 Polyclonal Antibody
Brand: abinScience
SKU: HV352014
Price: 168 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HV352014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ABCC2 (Ile1300-Glu1534).

Target

ATP-binding cassette sub-family C member 2, Multidrug resistance-associated protein 2, Canalicular multispecific organic anion transporter 1, ABCC2, CMOAT, Canalicular multidrug resistance protein, MRP2, CMRP, CMOAT1

Purification

Purified by antigen affinity column.

Accession

Q92887

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

ATP-binding cassette sub-family C member 2 (ABCC2) is a ~174 kDa protein. ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification. Also mediates hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Transports sulfated bile salt such as taurolithocholate sulfate.

1. Cui, Y. et al. (1999) Molecular pharmacology 55, 929-37. PMID: 10220572

2. Kamisako, T. et al. (1999) Hepatology (Baltimore, Md.) 30, 485-90. PMID: 10421658

3. Ito, K. et al. (2001) The Journal of biological chemistry 276, 38108-14. PMID: 11500505

4. Hayashi, H. et al. (2005) Biochimica et biophysica acta 1738, 54-62. PMID: 16332456

5. Huisman, MT. et al. (2002) AIDS (London, England) 16, 2295-301. PMID: 12441801

Note

For research use only.

Images

References

Datasheet

Anti-Human ABCC2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human ABCC2 Polyclonal Antibody (HV352014)

Overview

Images

References

Datasheet

SDS

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