

| Catalog No. | HP358014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Clonality | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogen | E. coli - derived recombinant Human ZC3H12D (Arg90-Pro231). | ||||||||
| Target | Probable ribonuclease ZC3H12D, MCP-induced protein 4, Zinc finger CCCH domain-containing protein 12D, TFL, Transformed follicular lymphoma, p34, MCPIP4, ZC3H12D, C6orf95 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | A2A288 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Probable ribonuclease ZC3H12D is a ~58 kDa protein. May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages. Serve as a tumor suppressor in certain leukemia cells. Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation. 1. Minagawa, K. et al. (2009) Molecular cancer research : MCR 7, 880-9. PMID: 19531561 2. Huang, S. et al. (2015) The Journal of biological chemistry 290, 20782-20792. PMID: 26134560 3. Wang, M. et al. (2007) Cancer research 67, 93-9. PMID: 17210687 | ||||||||
| Note | For research use only. |
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