Anti-Mouse CD19 Polyclonal Antibody (MB996014)

Name: Anti-Mouse CD19 Polyclonal Antibody
Brand: abinScience
SKU: MB996014
Price: 96 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

MB996014

Description

Anti-Mouse CD19 Polyclonal Antibody (MB996014) is a rabbit polyclonal antibody detecting CD19 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse CD19 (Ser23-Ser276).

Target

CD19, Differentiation antigen CD19, T-cell surface antigen Leu-12, B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4

Purification

Purified by antigen affinity column.

Accession

P25918

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

B-lymphocyte antigen CD19 is a ~60 kDa protein. Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. CD19 is the therapeutic target of tafasitamab (Monjuvi).

1. Wang, Y. et al. (2002) Immunity 17, 501-14. PMID: 12387743

2. Ishiura, N. et al. (2010) European journal of immunology 40, 1192-204. PMID: 20101619

3. Buhl, AM. et al. (1997) The Journal of experimental medicine 186, 1897-910. PMID: 9382888

4. Engel, P. et al. (1995) Immunity 3, 39-50. PMID: 7542548

5. Rickert, RC. et al. (1995) Nature 376, 352-5. PMID: 7543183

6. Sato, S. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 159, 3278-87. PMID: 9317126

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Mouse CD19 polyclonal antibody at 1ug/mL on recombinant Mouse CD19 (Catalog No. MB996012).

References

Datasheet