Anti-Mouse ACE2 Polyclonal Antibody (MV157014)

Name: Anti-Mouse ACE2 Polyclonal Antibody
Brand: abinScience
SKU: MV157014
Price: 96 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

MV157014

Description

Anti-Mouse ACE2 Polyclonal Antibody (MV157014) is a rabbit polyclonal antibody detecting ACE2 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse ACE2 (Ser617-Gly716).

Target

Angiotensin-converting enzyme homolog, ACE2, ACEH, Metalloprotease MPROT15, Angiotensin-converting enzyme-related carboxypeptidase, Angiotensin-converting enzyme 2, ACE-related carboxypeptidase

Purification

Purified by antigen affinity column.

Accession

Q8R0I0

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Angiotensin-converting enzyme 2 (ACE2) is a ~92 kDa protein. Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A. By cleavage of angiotensin II, may be an important regulator of heart function.

1. Crackower, MA. et al. (2002) Nature 417, 822-8. PMID: 12075344

2. Donoghue, M. et al. (2003) Journal of molecular and cellular cardiology 35, 1043-53. PMID: 12967627

3. Imai, Y. et al. (2005) Nature 436, 112-6. PMID: 16001071

4. Kowalczuk, S. et al. (2008) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22, 2880-7. PMID: 18424768

5. Camargo, SM. et al. (2009) Gastroenterology 136, 872-82. PMID: 19185582

6. Fairweather, SJ. et al. (2012) The Biochemical journal 446, 135-48. PMID: 22677001

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-ACE2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse testis lysate
Lane 2: Mouse lung lysate
Lane 3: Rat testis lysate

References

Datasheet

Anti-Mouse ACE2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse ACE2 Polyclonal Antibody (MV157014)

Overview

Images

References

Datasheet

SDS

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