Anti-Human CD368/CLEC4D Polyclonal Antibody (HV778014)

Name: Anti-Human CD368/CLEC4D Polyclonal Antibody
Brand: abinScience
SKU: HV778014
Price: 96 USD
Availability: InStock

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Overview
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Datasheet
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Overview

Catalog No.

HV778014

Description

Anti-Human CD368/CLEC4D Polyclonal Antibody (HV778014) is a rabbit polyclonal antibody detecting CLEC4D in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD368/CLEC4D (Cys39-Asn215).

Target

C-type lectin domain family 4 member D, C-type lectin superfamily member 8, C-type lectin-like receptor 6, CLEC-6, Dendritic cell-associated C-type lectin 3, DC-associated C-type lectin 3, Dectin-3, CD368, CLEC4D, CLECSF8, MCL

Purification

Purified by antigen affinity column.

Accession

Q8WXI8

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

C-type lectin domain family 4 member D (CD368/CLEC4D) is a ~24 kDa protein. Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells. Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. The heterodimer formed with CLEC6A is active against fungal infection.

1. Miyake, Y. et al. (2013) Immunity 38, 1050-62. PMID: 23602766

2. Zhu, LL. et al. (2013) Immunity 39, 324-34. PMID: 23911656

3. Arce, I. et al. (2004) European journal of immunology 34, 210-20. PMID: 14971047

Note

For research use only.

Images

References

Datasheet

Anti-Human CD368/CLEC4D Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human CD368/CLEC4D Polyclonal Antibody (HV778014)

Overview

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References

Datasheet

SDS

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