Anti-Human HTR4 Polyclonal Antibody (HC684024)

Name: Anti-Human HTR4 Polyclonal Antibody
Brand: abinScience
SKU: HC684024
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HC684024

Description

Anti-Human HTR4 Polyclonal Antibody (HC684024) is a rabbit polyclonal antibody detecting HTR4 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human HTR4.

Target

5-hydroxytryptamine receptor 4, 5-HT-4, 5-HT4, Serotonin receptor 4, HTR4

Purification

Purified by antigen affinity column.

Accession

Q13639

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

5-hydroxytryptamine receptor 4 (HTR4) is a ~43 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.

1. Mialet, J. et al. (2000) British journal of pharmacology 130, 527-38. PMID: 10821780

2. Kamel, R. et al. (2005) Biochemical pharmacology 70, 1009-18. PMID: 16102731

3. Huang, S. et al. (2022) Molecular cell 82, 2681-2695.e6. PMID: 35714614

4. Blondel, O. et al. (1998) Journal of neurochemistry 70, 2252-61. PMID: 9603189

Note

For research use only.

Images

References

Datasheet

Anti-Human HTR4 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human HTR4 Polyclonal Antibody (HC684024)

Overview

Images

References

Datasheet

SDS

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