Anti-Mouse CD47/MER6 Polyclonal Antibody (MC359014)

Name: Anti-Mouse CD47/MER6 Polyclonal Antibody
Brand: abinScience
SKU: MC359014
Price: 96 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

MC359014

Description

Anti-Mouse CD47/MER6 Polyclonal Antibody (MC359014) is a rabbit polyclonal antibody detecting CD47 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse CD47/MER6 (Gln19-Lys140).

Target

Leukocyte surface antigen CD47, Integrin-associated protein, IAP, CD47, Cd47

Purification

Purified by antigen affinity column.

Accession

Q61735

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Leukocyte surface antigen CD47 (MER6) is a ~33 kDa protein. Adhesive protein that mediates cell-to-cell interactions. Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins. Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation. Plays a role in modulating pulmonary endothelin EDN1 signaling. Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure. CD47 is the therapeutic target of magrolimab (clinical).

1. Bauer, EM. et al. (2010) Cardiovascular research 88, 471-81. PMID: 20610415

2. Kaur, S. et al. (2013) Scientific reports 3, 1673. PMID: 23591719

3. Rogers, NM. et al. (2017) Cardiovascular research 113, 15-29. PMID: 27742621

4. Manna, PP. et al. (2005) The Journal of biological chemistry 280, 29637-44. PMID: 15917238

5. Ghimire, K. et al. (2020) Cells 9. PMID: 32679764

6. Isenberg, JS. et al. (2008) Annals of surgery 247, 180-90. PMID: 18156939

7. Oldenborg, PA. et al. (2000) Science (New York, N.Y.) 288, 2051-4. PMID: 10856220

Note

For research use only.

Images

References

Datasheet

Anti-Mouse CD47/MER6 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse CD47/MER6 Polyclonal Antibody (MC359014)

Overview

Images

References

Datasheet

SDS

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