Anti-Mouse TP53/p53 Recombinant Antibody (PAb242) (MY039013)

Name: Anti-Mouse TP53/p53 Recombinant Antibody (PAb242)
Brand: abinScience
SKU: MY039013
Price: 110 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

MY039013

Species reactivity

Mouse

Applications

ELISA, IF, IHC, IP, RIA, WB

Host species

Rat

Isotype

IgG2a, kappa

Clone ID

PAb242

Clonality

Monoclonal

Target

Antigen NY-CO-13, Cellular tumor antigen p53, P53, Tumor suppressor p53, TP53, Phosphoprotein p53

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P02340

RRID

Anti-Mouse TP53/p53 Antibody (PAb242) (abinScience Cat# MY039013, RRID:AB_3725644)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Cellular tumor antigen p53 (TP53) is a ~43 kDa protein. Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

1. Allton, K. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 11612-6. PMID: 19556538

2. Huarte, M. et al. (2010) Cell 142, 409-19. PMID: 20673990

3. Vaseva, AV. et al. (2012) Cell 149, 1536-48. PMID: 22726440

4. Miki, T. et al. (2013) Nature communications 4, 2444. PMID: 24051492

Note

For research use only.

Images

Bioactivity

Detects Recombinant Mouse TP53/p53 Protein, N-His (Cat No.: MY039012) in indirect ELISA.

References

Datasheet

Anti-Mouse TP53/p53 Recombinant Antibody (PAb242).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse TP53/p53 Recombinant Antibody (PAb242) (MY039013)

Overview

Images

References

Datasheet

SDS

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