Anti-Human F2RL1/PAR-2 Antibody (SAA1956) (HX041013)

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50ug
100ug
1mg

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Datasheet

Overview

Catalog No.

HX041013

Description

Anti-Human F2RL1/PAR-2 Antibody (SAA1956) [SAA1956] (HX041013) is a mouse monoclonal antibody detecting F2RL1 in ELISA. Suitable for Human.

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1956

Clonality

Monoclonal

Target

GPR11, Thrombin receptor-like 1, G-protein coupled receptor 11, F2RL1, PAR-2, Coagulation factor II receptor-like 1, Proteinase-activated receptor 2, PAR2

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P55085

RRID

Anti-Human F2RL1/PAR-2 Antibody (SAA1956) (abinScience Cat# HX041013, RRID:AB_3727720)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Proteinase-activated receptor 2 (F2RL1/PAR-2) is a ~44 kDa protein. Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation.

1. Cheng, RKY. et al. (2017) Nature 545, 112-115. PMID: 28445455

2. Kuckleburg, CJ. et al. (2013) Arteriosclerosis, thrombosis, and vascular biology 33, 275-84. PMID: 23202369

3. Cocks, TM. et al. (1999) Nature 398, 156-60. PMID: 10086357

4. Botham, A. et al. (2011) The Biochemical journal 438, 359-67. PMID: 21627585

5. Manithody, C. et al. (2012) Biochemistry 51, 2551-7. PMID: 22409427

Note

For research use only.

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