Anti-Snapin/SNAPAP Recombinant Antibody (L8/15) (HF649013)

Name: Anti-Snapin/SNAPAP Recombinant Antibody (L8/15)
Brand: abinScience
SKU: HF649013
Price: 196 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HF649013

Description

Anti-Snapin/SNAPAP Recombinant Antibody (L8/15) (HF649013) is a mouse monoclonal antibody detecting Snapin/SNAPAP in IHC, WB.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Applications

IHC, WB

Host species

Mouse

Clonality

Monoclonal

Isotype

IgG2a, kappa

Clone ID

L8/15

Target

Synaptosomal-associated protein 25-binding protein, SNAPIN, Biogenesis of lysosome-related organelles complex 1 subunit 7, SNARE-associated protein Snapin, BLOC-1 subunit 7, BLOC1S7, SNAPAP, SNAP25BP, SNAP-associated protein

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

RRID

Anti-Snapin/SNAPAP Antibody (L8/15) (abinScience Cat# HF649013, RRID:AB_3728075)
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Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

SNARE-associated protein Snapin (SNAPAP) is a ~14 kDa protein. Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25.

1. Setty, SR. et al. (2007) Molecular biology of the cell 18, 768-80. PMID: 17182842

2. Granata, A. et al. (2008) The Journal of biological chemistry 283, 7568-79. PMID: 18167355

3. Pu, J. et al. (2015) Developmental cell 33, 176-88. PMID: 25898167

Note

For research use only.

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