Anti-SCN9A/Nav1.7 Recombinant Antibody (N68/6) (HS929023)

Name: Anti-SCN9A/Nav1.7 Recombinant Antibody (N68/6)
Brand: abinScience
SKU: HS929023
Price: 110 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HS929023

Description

Anti-SCN9A/Nav1.7 Recombinant Antibody (N68/6) (HS929023) is a mouse monoclonal antibody detecting SCN9A/Nav1.7 in IHC, WB.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Applications

IHC, WB

Host species

Mouse

Clonality

Monoclonal

Isotype

IgG2a, kappa

Clone ID

N68/6

Target

Sodium channel protein type 9 subunit alpha, NENA, Neuroendocrine sodium channel, Sodium channel protein type IX subunit alpha, SCN9A, Voltage-gated sodium channel subunit alpha Nav1.7, PN1, Peripheral sodium channel 1, hNE-Na

Endotoxin level

< 10 EU/mg

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

RRID

Anti-Nav1.7 Na+ channel Antibody (N68/6) (abinScience Cat# HS929023, RRID:AB_3728432)
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Form

Liquid

Storage buffer

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Sodium channel protein type 9 subunit alpha (SCN9A/Nav1.7) is a ~226 kDa protein. Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain.

1. Cummins, TR. et al. (2004) The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 8232-6. PMID: 15385606

2. Choi, JS. et al. (2006) Neurology 67, 1563-7. PMID: 16988069

3. Fertleman, CR. et al. (2006) Neuron 52, 767-74. PMID: 17145499

4. Cox, JJ. et al. (2006) Nature 444, 894-8. PMID: 17167479

5. Han, C. et al. (2009) Brain : a journal of neurology 132, 1711-22. PMID: 19369487

6. Eberhardt, M. et al. (2014) The Journal of biological chemistry 289, 1971-80. PMID: 24311784

7. Tan, ZY. et al. (2014) FEBS letters 588, 3964-9. PMID: 25240195

8. Ahuja, S. et al. (2015) Science (New York, N.Y.) 350, aac5464. PMID: 26680203

9. Klugbauer, N. et al. (1995) The EMBO journal 14, 1084-90. PMID: 7720699

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Nav1.7 Na+ channel Antibody (N68/6)
Bioactivity

Detects recombinant human SCN9A (Catalog No: HS929012) in indirect ELISA

References

Datasheet

Anti-SCN9A/Nav1.7 Recombinant Antibody (N68/6).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-SCN9A/Nav1.7 Recombinant Antibody (N68/6) (HS929023)

Overview

Images

References

Datasheet

SDS

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