Anti-Human Hepcidin Recombinant Antibody (SAA2725) (HX911023)

Name: Anti-Human Hepcidin Recombinant Antibody (SAA2725)
Brand: abinScience
SKU: HX911023
Price: 191 USD
Availability: InStock

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1mg

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Overview

Catalog No.	HX911023
Species reactivity	Human
Applications	ELISA
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	SAA2725
Clonality	Monoclonal
Target	HAMP, HEPC, Hepc20, Hepc25, Hepcidin, Hepcidin-20, Hepcidin-25, LEAP-1, LEAP1, Liver-expressed antimicrobial peptide 1, PLTR, Putative liver tumor regressor
Endotoxin level	<10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P81172
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Hepcidin is a ~9 kDa protein. Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes. 1. Qiao, B. et al. (2012) Cell metabolism 15, 918-24. PMID: 22682227 2. Aschemeyer, S. et al. (2018) Blood 131, 899-910. PMID: 29237594 3. Billesbølle, CB. et al. (2020) Nature 586, 807-811. PMID: 32814342 4. Ganz, T. et al. (2012) Biochimica et biophysica acta 1823, 1434-43. PMID: 22306005
Note	For research use only