Anti-Human CCKBR/CCK2-R Polyclonal Antibody (HB288014)

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Overview

Catalog No.

HB288014

Description

Anti-Human CCKBR/CCK2-R Polyclonal Antibody (HB288014) is a rabbit polyclonal antibody detecting CCK2-R. Suitable for Human.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CCKBR/CCK2-R (Arg243-Arg333).

Target

CCK-B receptor, CCK-BR, CCK2-R, CCKBR, CCKRB, Cholecystokinin-2 receptor, Gastrin/cholecystokinin type B receptor

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P32239

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Gastrin/cholecystokinin type B receptor (CCKBR/CCK2-R) is a ~48 kDa protein. Receptor for the peptide hormones gastrin and cholecystokinin (CCK). Expressed throughout the central nervous system, where it modulates processes such as anxiety, analgesia, arousal and neuroleptic activity. Couples to both GNAI1 and GNAQ signaling pathways, but not to GNAS. Upon gastrin activation, reduces glucose absorption in intestinal epithelial cells by downregulating SGLT1 and GLUT2 expression through suppression of the PI3K/Akt/eIF4B pathway. In the kidney, decreases SGLT2 expression under high-glucose conditions via ERK/NF-kappa-B signaling.

1. Zhang, X. et al. (2021) Nature chemical biology 17, 1230-1237. PMID: 34556863

Note

For research use only

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Datasheet