Anti-Human ERI1 Polyclonal Antibody (HV499014)

Name: Anti-Human ERI1 Polyclonal Antibody
Brand: abinScience
SKU: HV499014
Price: 168 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

50ug
100ug

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HV499014

Description

Anti-Human ERI1 Polyclonal Antibody (HV499014) is a rabbit polyclonal antibody detecting ERI1. Suitable for Human, Mouse, and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ERI1 (Pro64-Ser329).

Target

3'-5' exonuclease ERI1, 3'-5' exoribonuclease 1, 3'EXO, EC:3.1.13.1, ERI1, Eri-1 homolog, HEXO, Histone mRNA 3'-end-specific exoribonuclease, Histone mRNA 3'-exonuclease 1, Protein 3'hExo, THEX1

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q8IV48

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

3'-5' exoribonuclease 1 (ERI1) is a ~40 kDa protein. RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient 3'-end histone mRNA exonuclease activity and degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Required for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs.

1. Dominski, Z. et al. (2003) Molecular cell 12, 295-305. PMID: 14536070

2. Yang, XC. et al. (2006) The Journal of biological chemistry 281, 30447-54. PMID: 16912046

3. Kupsco, JM. et al. (2006) RNA (New York, N.Y.) 12, 2103-17. PMID: 17135487

4. Guo, L. et al. (2023) American journal of human genetics 110, 1068-1085. PMID: 37352860

5. Kennedy, S. et al. (2004) Nature 427, 645-9. PMID: 14961122

Note

For research use only

Images

References

Datasheet

Anti-Human ERI1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human ERI1 Polyclonal Antibody (HV499014)

Overview

Images

References

Datasheet

SDS

Quick access

Contact Us