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Anti-Human ROBO1 Polyclonal Antibody (HP485024)

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Overview
Catalog No.HP485024
Description
Anti-Human ROBO1 Polyclonal Antibody (HP485024) is a rabbit polyclonal antibody detecting ROBO1. Suitable for Human, Mouse, and Rat.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human ROBO1 (Arg69-Glu260).
Target DUTT1, Deleted in U twenty twenty, H-Robo-1, ROBO1, Roundabout homolog 1
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q9Y6N7
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Roundabout homolog 1 (ROBO1) is a ~180 kDa protein. Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA. May be required for lung development.

1. Brose, K. et al. (1999) Cell 96, 795-806. PMID: 10102268
2. Leyva-Díaz, E. et al. (2014) Current biology : CB 24, 494-508. PMID: 24560577
3. Kong, R. et al. (2015) The Journal of clinical investigation 125, 4407-20. PMID: 26529257
Note For research use only
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Formula
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V₁ (Stock Vol.)
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Anti-Human ROBO1 Polyclonal Antibody

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