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Anti-Mouse CD21/CR2 Polyclonal Antibody (MB939014)

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Overview
Catalog No.MB939014
Description
Anti-Mouse CD21/CR2 Polyclonal Antibody (MB939014) is a rabbit polyclonal antibody detecting CD21. Suitable for Mouse.
Species reactivityMouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse CD21/CR2 (Ile12-Ala205).
Target C3DR, CD21, CR2, Complement C3d receptor, Complement receptor type 2, Cr2, EBV receptor, Epstein-Barr virus receptor
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P19070
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Complement receptor type 2 (CD21/CR2) is a ~112 kDa protein. Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner.

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Anti-Mouse CD21/CR2 Polyclonal Antibody

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