Anti-Human SLC6A4 Polyclonal Antibody (HB725014)

Name: Anti-Human SLC6A4 Polyclonal Antibody
Brand: abinScience
SKU: HB725014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HB725014

Description

Anti-Human SLC6A4 Polyclonal Antibody (HB725014) is a rabbit polyclonal antibody detecting Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4; SLC6A4; HTT; SERT. Suitable for Mouse and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human SLC6A4 (Ala181-Ser252).

Target

Sodium-dependent serotonin transporter; SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4; SLC6A4; HTT; SERT

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P31645

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Sodium-dependent serotonin transporter (SLC6A4) is a ~70 kDa protein. Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling. Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse.

1. Mortensen, OV. et al. (1999) Brain research. Molecular brain research 71, 120-6. PMID: 10407194

2. Kilic, F. et al. (2003) Molecular pharmacology 64, 440-6. PMID: 12869649

3. Henry, LK. et al. (2011) The Journal of biological chemistry 286, 30823-30836. PMID: 21730057

4. Coleman, JA. et al. (2016) Nature 532, 334-9. PMID: 27049939

5. Hasenhuetl, PS. et al. (2016) The Journal of biological chemistry 291, 25864-25876. PMID: 27756841

6. Yang, D. et al. (2021) Science advances 7, eabl3857. PMID: 34851672

7. Brenner, B. et al. (2007) Journal of neurochemistry 102, 206-15. PMID: 17506858

8. Carneiro, AM. et al. (2008) The Journal of clinical investigation 118, 1544-52. PMID: 18317590

Note

For research use only

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References