Anti-Human NKG2A/CD159a Recombinant Antibody (S-095029) (HB188013)

Name: Anti-Human NKG2A/CD159a Recombinant Antibody (S-095029)
Brand: abinScience
SKU: HB188013
Price: 191 USD
Availability: InStock

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100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HB188013

Description

Anti-Human NKG2A/CD159a Recombinant Antibody (S-095029) (HB188013) is a human monoclonal antibody detecting NKG2A/CD159a in ELISA, FACS, Functional assay. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, FACS, Functional assay

Host species

Human

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone ID

S-095029

Target

CD159 antigen-like family member A, CD159a, KLRC1, NK cell receptor A, NKG2-A/B-activating NK receptor, NKG2-A/NKG2-B type II integral membrane protein, NKG2A

Endotoxin level

< 10 EU/mg as determined by LAL method.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P26715

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

NKG2-A/NKG2-B type II integral membrane protein (CD159a/KLRC1) is a ~26 kDa protein. Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions.

1. Sullivan, LC. et al. (2007) Immunity 27, 900-11. PMID: 18083576

2. Lin, Z. et al. (2023) Nature immunology 24, 1087-1097. PMID: 37264229

3. Valiante, NM. et al. (1997) Immunity 7, 739-51. PMID: 9430220

4. Braud, VM. et al. (1998) Nature 391, 795-9. PMID: 9486650

5. Kabat, J. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 169, 1948-58. PMID: 12165520

6. Le Dréan, E. et al. (1998) European journal of immunology 28, 264-76. PMID: 9485206

7. Kamiya, T. et al. (2019) The Journal of clinical investigation 129, 2094-2106. PMID: 30860984

8. Jabri, B. et al. (2002) Immunity 17, 487-99. PMID: 12387742

9. Bhagat, G. et al. (2008) The Journal of clinical investigation 118, 281-93. PMID: 18064301

Note

For research use only.

Isotype Control

Human IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107)

Images

References

Datasheet

Anti-Human NKG2A/CD159a Recombinant Antibody (S-095029).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human NKG2A/CD159a Recombinant Antibody (S-095029) (HB188013)

Overview

Images

References

Datasheet

SDS