Anti-Human DNAM-1/CD226 Recombinant Antibody (Lilly patent anti-CD226) (HS737013)

Name: Anti-Human DNAM-1/CD226 Recombinant Antibody (Lilly patent anti-CD226)
Brand: abinScience
SKU: HS737013
Price: 191 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HS737013

Description

Anti-Human DNAM-1/CD226 Recombinant Antibody (Lilly patent anti-CD226) (HS737013) is a human monoclonal antibody detecting DNAM-1/CD226 in ELISA. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.

Species reactivity

Human

Applications

ELISA

Host species

Human

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone ID

Lilly patent anti-CD226

Target

CD226, CD226 antigen, DNAM-1, DNAM1, DNAX accessory molecule 1

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q15762

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

CD226 antigen (DNAM-1) is a ~38 kDa protein. Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells. Functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells. Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes.

1. Shibuya, A. et al. (1996) Immunity 4, 573-81. PMID: 8673704

2. Shibuya, A. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 161, 1671-6. PMID: 9712030

3. Zhu, Y. et al. (2016) The Journal of experimental medicine 213, 167-76. PMID: 26755705

4. Deuss, FA. et al. (2019) The Journal of biological chemistry 294, 12534-12546. PMID: 31253644

5. Wang, H. et al. (2019) Proceedings of the National Academy of Sciences of the United States of America 116, 988-996. PMID: 30591568

Note

For research use only

Images

References

Datasheet

Anti-Human DNAM-1/CD226 Recombinant Antibody (Lilly patent anti-CD226).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human DNAM-1/CD226 Recombinant Antibody (Lilly patent anti-CD226) (HS737013)

Overview

Images

References

Datasheet

SDS

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