Anti-Human IL-1 RI Reference Antibody (Tesrakitug, RUO) (HB791036)

Name: Anti-Human IL-1 RI Reference Antibody (Tesrakitug, RUO)
Brand: abinScience
SKU: HB791036
Price: 370 USD
Availability: InStock

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100ug
1mg

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Overview

Catalog No.	HB791036
Description	Anti-Human IL-1 RI Reference Antibody (Tesrakitug, RUO) (HB791036) is a human monoclonal antibody detecting IL-1 RI.
Species reactivity	Human
Applications	ELISA, FACS, Functional assay
Host species	Human
Clonality	Monoclonal
Isotype	IgG2, kappa
Target	CD121 antigen-like family member A, CD121a, EC:3.2.2.6, IL-1R-1, IL-1R-alpha, IL-1RT-1, IL-1RT1, IL1R, IL1R1, IL1RA, IL1RT1, Interleukin-1 receptor alpha, Interleukin-1 receptor type 1, Interleukin-1 receptor type 1, membrane form, Interleukin-1 receptor type 1, soluble form, Interleukin-1 receptor type I, mIL-1R1, mIL-1RI, p80, sIL-1R1, sIL-1RI
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P14778
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term from the date of receipt..
Alternate Names	CAS: 3078753-82-6
Background	Interleukin-1 receptor type 1 (CD121a/IL1R1) is a ~65 kDa protein. Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. 1. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091 2. Wang, Y. et al. (2023) Immunity 56, 1485-1501.e7. PMID: 37315560 3. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850
Note	For research use only.