Anti-BKPyV VP1 Recombinant Antibody (SAA3067) (VK452063)

Name: Anti-BKPyV VP1 Recombinant Antibody (SAA3067)
Brand: abinScience
SKU: VK452063
Price: 191 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

VK452063

Description

Anti-BKPyV VP1 Recombinant Antibody (SAA3067) (VK452063) is a human monoclonal antibody detecting VP1 in ELISA, FCM, Neutralization. Suitable for BK polyomavirus (BKPyV).

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

BK polyomavirus (BKPyV)

Applications

ELISA, FCM, Neutralization

Host species

Human

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone ID

SAA3067

Target

Major capsid protein VP1, Major structural protein VP1

Endotoxin level

< 10 EU/mg

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P14996

Form

Liquid

Storage buffer

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Capsid protein VP1 is a ~81 kDa protein. Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s).

Note

For research use only

Images

References

Datasheet