Anti-CD160 Polyclonal Antibody (HF985014)

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Datasheet

Overview

Catalog No.

HF985014

Description

Anti-CD160 Polyclonal Antibody (HF985014) is a rabbit polyclonal antibody detecting CD160 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD160 (Gly37-Asn154).

Target

Natural killer cell receptor BY55, CD160 antigen, CD160, BY55

Purification

Purified by antigen affinity column.

Accession

O95971

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

CD160 antigen is a ~19 kDa protein. Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells. Receptor for both classical and non-classical MHC class I molecules. In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response. On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells.

1. Nikolova, M. et al. (2002) International immunology 14, 445-51. PMID: 11978774

2. Rabot, M. et al. (2007) International immunology 19, 401-9. PMID: 17307798

3. Giustiniani, J. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 63-71. PMID: 19109136

4. Le Bouteiller, P. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 16963-8. PMID: 12486241

5. Agrawal, S. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 162, 1223-6. PMID: 9973372

6. Viganò, S. et al. (2014) PLoS pathogens 10, e1004380. PMID: 25255144

7. Fons, P. et al. (2006) Blood 108, 2608-15. PMID: 16809620

8. Cai, G. et al. (2008) Nature immunology 9, 176-85. PMID: 18193050

Note

For research use only.

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