Anti-CD107b/LAMP2 Polyclonal Antibody (HY293014)

Name: Anti-CD107b/LAMP2 Polyclonal Antibody
Brand: abinScience
SKU: HY293014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HY293014

Description

Anti-CD107b/LAMP2 Polyclonal Antibody (HY293014) is a rabbit polyclonal antibody detecting CD107b in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD107b/LAMP2 (Leu29-Gln366).

Target

LGP-96, CD107b, LAMP2, CD107 antigen-like family member B, Lysosome-associated membrane glycoprotein 2, Lysosome-associated membrane protein 2, LAMP-2

Purification

Purified by antigen affinity column.

Accession

P13473

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Lysosome-associated membrane glycoprotein 2 (CD107b/LAMP2) is a ~44 kDa protein. Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. Functions by binding target proteins, such as GAPDH, GPX4, NLRP3 and MLLT11, and targeting them for lysosomal degradation. In the chaperone-mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2.

1. Cuervo, AM. et al. (2000) Journal of cell science 113 Pt 24, 4441-50. PMID: 11082038

2. Bandyopadhyay, U. et al. (2008) Molecular and cellular biology 28, 5747-63. PMID: 18644871

3. Li, P. et al. (2014) Experimental cell research 327, 48-56. PMID: 24880125

4. Hubert, V. et al. (2016) Biology open 5, 1516-1529. PMID: 27628032

5. Wang, L. et al. (2023) Molecular cell 83, 281-297.e10. PMID: 36586411

6. Zhang, J. et al. (2023) Molecular cell 83, 2524-2539.e7. PMID: 37390818

7. Cuervo, AM. et al. (1996) Science (New York, N.Y.) 273, 501-3. PMID: 8662539

Note

For research use only.

Images

References

Datasheet

Anti-CD107b/LAMP2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-CD107b/LAMP2 Polyclonal Antibody (HY293014)

Overview

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References

Datasheet

SDS

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